Real-World Effectiveness of Dulaglutide in Patients with Type 2 Diabetes Mellitus: A Literature Review View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-06-10

AUTHORS

Susan Robinson, Kristina S. Boye, Reema Mody, Alena Antonie Strizek, Manige Konig, Raleigh E. Malik, Tessa Kennedy-Martin

ABSTRACT

IntroductionRandomized controlled trials (RCTs) have demonstrated the efficacy of dulaglutide in adults with type 2 diabetes mellitus (T2DM), but results may not be generalizable in routine practice. This pragmatic literature review aimed to summarize real-world evidence (RWE) for dulaglutide.MethodsThe MEDLINE, EMBASE, NHS Economic Evaluation Database, and Health Technology Assessment databases were searched from January 2014 to July 2019 for studies providing RWE for dulaglutide in adults with T2DM regarding at least one outcome of interest (change in glycated hemoglobin [HbA1c]; weight; adherence; persistence; discontinuation; costs; healthcare resource utilization; health-related quality of life; patient satisfaction; and preference). Relevant congress abstracts were identified from EMBASE.ResultsA total of 29 studies (11 articles; 18 abstracts) were included. RWE for dulaglutide was not identified for all outcomes of interest. Dulaglutide reduced HbA1c from baseline to 3–24 months by 0.5–2.2% across studies (n = 20), and 23.4–55.7% of patients achieved HbA1c < 7.0%. Weight was reduced by 2.1–6.4 kg across studies of 3–12 months (n = 15). Based on outcomes from ten studies, 27.2–61.0% of dulaglutide patients were adherent. Mean persistence was 146–152 days and > 250 days in 6- and 12-month studies, respectively. Most studies reported discontinuation rates of 26.2–37.0%. Adherence and persistence were consistently reported to be greater in dulaglutide-treated patients in RW settings compared with other glucagon-like peptide-1 receptor agonists. Dulaglutide was associated with lower costs per 1% reduction in HbA1c compared with exenatide, liraglutide, or basal insulin (n = 3 studies).ConclusionEvidence from RWE studies suggests that dulaglutide may be associated with clinically relevant reductions in HbA1c, with a favorable adherence, persistence, and discontinuation profile in patients with T2DM in routine clinical practice. These findings provide additional insights regarding the potential value of dulaglutide in real-world settings that may assist healthcare decision makers in the delivery of patient-centered care. More... »

PAGES

1437-1466

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13300-020-00839-5

DOI

http://dx.doi.org/10.1007/s13300-020-00839-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1128395219

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32524494


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