Ontology type: schema:ScholarlyArticle Open Access: True
2017-12
AUTHORSLaure de Decker, Olivier Hanon, Anne-Sophie Boureau, Guillaume Chapelet, Christelle Dibon, Matthieu Pichelin, Gilles Berrut, Bertrand Cariou
ABSTRACTINTRODUCTION: From a patient-centered perspective, the assessment of risk factors of hypoglycemia is of critical importance for the management of type 2 diabetes (T2D). However, the association between the occurrence of hypoglycemia and high burden of comorbidities has been poorly studied in vulnerable older patients. Here, we aimed to determine whether a high burden of comorbidities is associated with hypoglycemia in very old patients with T2D. METHODS: A total of 1552 elderly (age ≥ 80 years old) patients with T2D were recruited in a nationwide cross-sectional study performed in French geriatric care units. Hypoglycemia was defined as a confirmed blood glucose value level ≤ 70 mg/dL. Comorbidities were assessed using the Charlson Comorbidity Index (CCI). RESULTS: Amongst the 1552 recruited patients (mean age 86.4 years), 415 (26.7%) had documented hypoglycemia. Compared to patients in whom hypoglycemia was not reported, they have a lower body weight (p = 0.004), a reduced eGFR (p < 0.001), a greater level of dependency (p < 0.001) as well as history of dementia (p = 0.006) and cardiovascular disease (p < 0.001), and a higher CCI (4.7 vs 3.8, p < 0.001). Patients with hypoglycemia had a higher frequency of daily self-monitoring blood glucose (SMBG) (p < 0.001) and insulin use (p < 0.001), with reduced sulfonylurea use (p < 0.001). In multivariate logistic regression analysis, insulin therapy (OR 3.32, p < 0.001), daily SMBG (OR 1.79, p = 0.02), CCI (OR 1.24, p = 0.01), and age (OR 0.96, p = 0.03) were independently associated with the risk of hypoglycemia. CONCLUSION: In addition to insulin therapy, a high burden of comorbidities was independently associated with hypoglycemia in older vulnerable patients with T2D. More... »
PAGES1405-1413
http://scigraph.springernature.com/pub.10.1007/s13300-017-0319-7
DOIhttp://dx.doi.org/10.1007/s13300-017-0319-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1092445325
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29086351
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Centre Hospitalier Universitaire de Nantes",
"id": "https://www.grid.ac/institutes/grid.277151.7",
"name": [
"Laboratory of clinical and experimental therapeutics of infections, EA 3628, Nantes University, 44000, Nantes, France",
"Department of Geriatrics, Nantes University Hospital, 44000, Nantes, France"
],
"type": "Organization"
},
"familyName": "de Decker",
"givenName": "Laure",
"id": "sg:person.0620656503.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620656503.70"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Broca",
"id": "https://www.grid.ac/institutes/grid.413802.c",
"name": [
"Department of Geriatrics, Broca Hospital, Public Hospital of Paris, 75013 Paris, France",
"Laboratory of Alzheimer disease\u00a0: genetic and vascular markers, neuropsychology, psychosocial interventions and technologies, EA 4468, Paris Descartes University, Sorbonne Paris Cit\u00e9, 75006 Paris, France"
],
"type": "Organization"
},
"familyName": "Hanon",
"givenName": "Olivier",
"id": "sg:person.01117245562.57",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117245562.57"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Universitaire de Nantes",
"id": "https://www.grid.ac/institutes/grid.277151.7",
"name": [
"Department of Geriatrics, Nantes University Hospital, 44000, Nantes, France"
],
"type": "Organization"
},
"familyName": "Boureau",
"givenName": "Anne-Sophie",
"id": "sg:person.0745266454.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745266454.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Universitaire de Nantes",
"id": "https://www.grid.ac/institutes/grid.277151.7",
"name": [
"Laboratory of clinical and experimental therapeutics of infections, EA 3628, Nantes University, 44000, Nantes, France",
"Department of Geriatrics, Nantes University Hospital, 44000, Nantes, France"
],
"type": "Organization"
},
"familyName": "Chapelet",
"givenName": "Guillaume",
"id": "sg:person.01004605710.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004605710.94"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Universitaire de Nantes",
"id": "https://www.grid.ac/institutes/grid.277151.7",
"name": [
"Department of Geriatrics, Nantes University Hospital, 44000, Nantes, France"
],
"type": "Organization"
},
"familyName": "Dibon",
"givenName": "Christelle",
"id": "sg:person.01025326236.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025326236.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Universitaire de Nantes",
"id": "https://www.grid.ac/institutes/grid.277151.7",
"name": [
"Department of Endocrinology, l\u2019institut du thorax, Nantes University Hospital, 44000, Nantes, France"
],
"type": "Organization"
},
"familyName": "Pichelin",
"givenName": "Matthieu",
"id": "sg:person.01056072501.92",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056072501.92"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Universitaire de Nantes",
"id": "https://www.grid.ac/institutes/grid.277151.7",
"name": [
"Department of Geriatrics, Nantes University Hospital, 44000, Nantes, France"
],
"type": "Organization"
},
"familyName": "Berrut",
"givenName": "Gilles",
"id": "sg:person.01073625774.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073625774.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Universitaire de Nantes",
"id": "https://www.grid.ac/institutes/grid.277151.7",
"name": [
"Department of Endocrinology, l\u2019institut du thorax, Nantes University Hospital, 44000, Nantes, France"
],
"type": "Organization"
},
"familyName": "Cariou",
"givenName": "Bertrand",
"id": "sg:person.0604736260.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604736260.19"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1370/afm.983",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003049670"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/dc11-2054",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003837238"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/dom.12211",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005237625"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.pcd.2013.10.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008523653"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jamda.2016.07.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008702449"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1932296815602905",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009991203"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1932296815602905",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009991203"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diacare.28.5.1245",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011944865"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archinternmed.2010.539",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015719294"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bmj.b4909",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020576878"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0021-9681(87)90171-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020988115"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jcjd.2015.05.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021772772"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.diabet.2014.10.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021829037"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.amjmed.2011.07.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021958482"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.diabres.2013.11.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025250404"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0168-8227(09)70011-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026446816"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0021-9681(70)90054-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034312464"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/dom.12031",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041449960"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/dc11-1470",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042821969"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/dc12-0916",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044633230"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jamda.2014.12.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045381155"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmsa1103053",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046654903"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/dc12-1296",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046694419"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archinte.163.15.1825",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049550382"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jamda.2014.06.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050008366"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrendo.2014.170",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051668850",
"https://doi.org/10.1038/nrendo.2014.170"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.14336/ad.2014.0330",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1067267901"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diacare.20.2.135",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1070747547"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4239/wjd.v6.i1.30",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072397555"
],
"type": "CreativeWork"
}
],
"datePublished": "2017-12",
"datePublishedReg": "2017-12-01",
"description": "INTRODUCTION: From a patient-centered perspective, the assessment of risk factors of hypoglycemia is of critical importance for the management of type 2 diabetes (T2D). However, the association between the occurrence of hypoglycemia and high burden of comorbidities has been poorly studied in vulnerable older patients. Here, we aimed to determine whether a high burden of comorbidities is associated with hypoglycemia in very old patients with T2D.\nMETHODS: A total of 1552 elderly (age\u00a0\u2265\u00a080\u00a0years old) patients with T2D were recruited in a nationwide cross-sectional study performed in French geriatric care units. Hypoglycemia was defined as a confirmed blood glucose value level\u00a0\u2264\u00a070\u00a0mg/dL. Comorbidities were assessed using the Charlson Comorbidity Index (CCI).\nRESULTS: Amongst the 1552 recruited patients (mean age 86.4\u00a0years), 415 (26.7%) had documented hypoglycemia. Compared to patients in whom hypoglycemia was not reported, they have a lower body weight (p\u00a0=\u00a00.004), a reduced eGFR (p\u00a0<\u00a00.001), a greater level of dependency (p\u00a0<\u00a00.001) as well as history of dementia (p\u00a0=\u00a00.006) and cardiovascular disease (p\u00a0<\u00a00.001), and a higher CCI (4.7 vs 3.8, p\u00a0<\u00a00.001). Patients with hypoglycemia had a higher frequency of daily self-monitoring blood glucose (SMBG) (p\u00a0<\u00a00.001) and insulin use (p\u00a0<\u00a00.001), with reduced sulfonylurea use (p\u00a0<\u00a00.001). In multivariate logistic regression analysis, insulin therapy (OR 3.32, p\u00a0<\u00a00.001), daily SMBG (OR 1.79, p\u00a0=\u00a00.02), CCI (OR 1.24, p\u00a0=\u00a00.01), and age (OR 0.96, p\u00a0=\u00a00.03) were independently associated with the risk of hypoglycemia.\nCONCLUSION: In addition to insulin therapy, a high burden of comorbidities was independently associated with hypoglycemia in older vulnerable patients with T2D.",
"genre": "research_article",
"id": "sg:pub.10.1007/s13300-017-0319-7",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1044057",
"issn": [
"1869-6953",
"1869-6961"
],
"name": "Diabetes Therapy",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "8"
}
],
"name": "Association Between Hypoglycemia and the Burden of Comorbidities in Hospitalized Vulnerable Older Diabetic Patients: A Cross-Sectional, Population-Based Study",
"pagination": "1405-1413",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"c0b7a2d732163e93a83d19c3ef079253f7556ec3761d697559ad6dd5138b38d4"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29086351"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101539025"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s13300-017-0319-7"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1092445325"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s13300-017-0319-7",
"https://app.dimensions.ai/details/publication/pub.1092445325"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T02:24",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000572.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs13300-017-0319-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13300-017-0319-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13300-017-0319-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13300-017-0319-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13300-017-0319-7'
This table displays all metadata directly associated to this object as RDF triples.
209 TRIPLES
21 PREDICATES
57 URIs
21 LITERALS
9 BLANK NODES