Experience with Vildagliptin in Type 2 Diabetic Patients Fasting During Ramadan in France: Insights from the VERDI Study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Serge Halimi, Marc Levy, Dominique Huet, Stéphane Quéré, Sylvie Dejager

ABSTRACT

AIM: To assess in real life the rate of hypoglycemia during Ramadan in patients with type 2 diabetes (T2DM) in France, according to their ongoing dual therapy of metformin-vildagliptin or metformin-sulfonylurea/glinide (IS). METHODS: Prospective, non-interventional study with 2 visits (within 8 weeks before and 6 weeks after the end of Ramadan 2012). Study diaries were not used to collect events or record values of glucose monitoring. One hundred and ninety-eight patients on stable oral dual therapy for ≥2 months and with glycosylated hemoglobin (HbA1c) ≤8.0% were recruited by 62 centers: 83 in the IS cohort and 115 in the vildagliptin cohort. RESULTS: Approximately 90% of patients were from Maghreb. The two cohorts were well balanced: 60% men, mean age 59 years, BMI 28 kg/m(2), metformin dose ~2,000 mg/day, and HbA1c 7.2%. Distinct therapeutic management was planned in view of Ramadan with drug-adaptation intended in 61.4% of IS and 18.3% of vildagliptin patients. Hypoglycemia was reported in 37% of IS and 34% of vildagliptin patients; episodes declared as confirmed in 30.8% and 23.5%, respectively, and episodes documented as adverse event (AE) in 17.9% (22 episodes) and 7.5% (13 episodes), respectively (P = 0.025). Severe episodes were reported in 3.9% of IS and 1.7% of vildagliptin patients. 10.4% of IS and 2.6% of vildagliptin patients reported severe episodes and/or unscheduled medical visits due to hypoglycemia (P = 0.029). Glycemic control remained stable in both cohorts. Compliance with fasting was high, as well as adherence to drug with ≥5 missed-dose for 15.4% of IS and 8.5% of vildagliptin patients. CONCLUSION: Although the overall frequency of malaise suggestive of hypoglycemia was high, which would be expected with prolonged fasting in a well-controlled T2DM population during hot summer days, the incidence of more severe and better-documented episodes (AE, severe event, event leading to unscheduled medical visit) were much lower, with consistently less events with vildagliptin therapy. More... »

PAGES

385-398

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13300-013-0038-7

DOI

http://dx.doi.org/10.1007/s13300-013-0038-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014993206

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23996548


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Joseph Fourier University", 
          "id": "https://www.grid.ac/institutes/grid.9621.c", 
          "name": [
            "Department of Diabetology, Endocrinology and Nutrition, CHU Hospital Grenoble, and University Joseph Fourier, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Halimi", 
        "givenName": "Serge", 
        "id": "sg:person.01205660265.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205660265.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Diabetology and Endocrinology, Max Fourestier Hospital, Nanterre, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levy", 
        "givenName": "Marc", 
        "id": "sg:person.01345244315.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345244315.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Joseph", 
          "id": "https://www.grid.ac/institutes/grid.414363.7", 
          "name": [
            "Department of Diabetology and Endocrinology, Saint-Joseph Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huet", 
        "givenName": "Dominique", 
        "id": "sg:person.01170602375.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170602375.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (France)", 
          "id": "https://www.grid.ac/institutes/grid.418380.6", 
          "name": [
            "Biostatistics, Novartis Pharma SAS, Rueil Malmaison, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qu\u00e9r\u00e9", 
        "givenName": "St\u00e9phane", 
        "id": "sg:person.01353144175.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353144175.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (France)", 
          "id": "https://www.grid.ac/institutes/grid.418380.6", 
          "name": [
            "Medical Affairs, Novartis Pharma SAS, 2-4 rue Lionel Terray, 92 506, Rueil Malmaison, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dejager", 
        "givenName": "Sylvie", 
        "id": "sg:person.01323162303.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323162303.56"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.diabet.2010.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002194006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.2011.03563.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008055608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/2230-8210.97994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009800199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-1241.2011.02797.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011105045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1463-1326.2010.01325.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011802425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1463-1326.2010.01325.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011802425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmrr.1137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012192111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmrr.1137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012192111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/03007995.2011.578245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012851198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-008-1220-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013840377", 
          "https://doi.org/10.1007/s00125-008-1220-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-008-1220-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013840377", 
          "https://doi.org/10.1007/s00125-008-1220-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-008-1220-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013840377", 
          "https://doi.org/10.1007/s00125-008-1220-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.29.03.06.dc05-2102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019091258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-1241.2009.02171.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022078283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-1241.2009.02171.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022078283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1463-1326.2010.01233.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023139110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1463-1326.2010.01233.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023139110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-8227(02)00104-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023648010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/03007995.2011.579951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024380810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.2010.02948.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027050111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.2010.02948.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027050111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc10-0896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029324537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1463-1326.2008.00994.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036104286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0003-4266(04)96003-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037049033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0003-4266(04)96003-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037049033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ijcp.12243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037348712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/03007995.2012.707119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037645721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.304.6826.521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037707159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11096-012-9716-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039702095", 
          "https://doi.org/10.1007/s11096-012-9716-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.diabet.2012.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043326201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13300-010-0018-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044900948", 
          "https://doi.org/10.1007/s13300-010-0018-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.29.03.06.dc05-2184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045125907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/2230-8210.97996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047652860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/03007995.2013.803054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048319643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-1241.2009.02262.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050288641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-1241.2009.02262.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050288641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/dmso.s23261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050800747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.27.10.2306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052498569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.28.2.421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052905869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12968/bjcn.2001.6.11.9459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064774525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.21.9.1414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070748416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3810/hp.2012.04.965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071437585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3810/hp.2013.04.1059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071437648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076844888", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077163706", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "AIM: To assess in real life the rate of hypoglycemia during Ramadan in patients with type 2 diabetes (T2DM) in France, according to their ongoing dual therapy of metformin-vildagliptin or metformin-sulfonylurea/glinide (IS).\nMETHODS: Prospective, non-interventional study with 2 visits (within 8\u00a0weeks before and 6\u00a0weeks after the end of Ramadan 2012). Study diaries were not used to collect events or record values of glucose monitoring. One hundred and ninety-eight patients on stable oral dual therapy for \u22652\u00a0months and with glycosylated hemoglobin (HbA1c) \u22648.0% were recruited by 62 centers: 83 in the IS cohort and 115 in the vildagliptin cohort.\nRESULTS: Approximately 90% of patients were from Maghreb. The two cohorts were well balanced: 60% men, mean age 59\u00a0years, BMI 28\u00a0kg/m(2), metformin dose ~2,000\u00a0mg/day, and HbA1c 7.2%. Distinct therapeutic management was planned in view of Ramadan with drug-adaptation intended in 61.4% of IS and 18.3% of vildagliptin patients. Hypoglycemia was reported in 37% of IS and 34% of vildagliptin patients; episodes declared as confirmed in 30.8% and 23.5%, respectively, and episodes documented as adverse event (AE) in 17.9% (22 episodes) and 7.5% (13 episodes), respectively (P\u00a0=\u00a00.025). Severe episodes were reported in 3.9% of IS and 1.7% of vildagliptin patients. 10.4% of IS and 2.6% of vildagliptin patients reported severe episodes and/or unscheduled medical visits due to hypoglycemia (P\u00a0=\u00a00.029). Glycemic control remained stable in both cohorts. Compliance with fasting was high, as well as adherence to drug with \u22655 missed-dose for 15.4% of IS and 8.5% of vildagliptin patients.\nCONCLUSION: Although the overall frequency of malaise suggestive of hypoglycemia was high, which would be expected with prolonged fasting in a well-controlled T2DM population during hot summer days, the incidence of more severe and better-documented episodes (AE, severe event, event leading to unscheduled medical visit) were much lower, with consistently less events with vildagliptin therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s13300-013-0038-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1044057", 
        "issn": [
          "1869-6953", 
          "1869-6961"
        ], 
        "name": "Diabetes Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Experience with Vildagliptin in Type 2 Diabetic Patients Fasting During Ramadan in France: Insights from the VERDI Study", 
    "pagination": "385-398", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "476eb785bbb7aed9a50d5263d471ef6d49d04c46b231d0234c198ce8afefdac1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23996548"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101539025"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13300-013-0038-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014993206"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13300-013-0038-7", 
      "https://app.dimensions.ai/details/publication/pub.1014993206"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000521.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs13300-013-0038-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13300-013-0038-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13300-013-0038-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13300-013-0038-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13300-013-0038-7'


 

This table displays all metadata directly associated to this object as RDF triples.

215 TRIPLES      21 PREDICATES      65 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13300-013-0038-7 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N13d839a10c5046c58ccb5b23c0797cbf
4 schema:citation sg:pub.10.1007/s00125-008-1220-8
5 sg:pub.10.1007/s11096-012-9716-1
6 sg:pub.10.1007/s13300-010-0018-0
7 https://app.dimensions.ai/details/publication/pub.1076844888
8 https://app.dimensions.ai/details/publication/pub.1077163706
9 https://doi.org/10.1002/dmrr.1137
10 https://doi.org/10.1016/j.diabet.2010.12.010
11 https://doi.org/10.1016/j.diabet.2012.08.003
12 https://doi.org/10.1016/s0003-4266(04)96003-9
13 https://doi.org/10.1016/s0168-8227(02)00104-3
14 https://doi.org/10.1111/ijcp.12243
15 https://doi.org/10.1111/j.1463-1326.2008.00994.x
16 https://doi.org/10.1111/j.1463-1326.2010.01233.x
17 https://doi.org/10.1111/j.1463-1326.2010.01325.x
18 https://doi.org/10.1111/j.1464-5491.2010.02948.x
19 https://doi.org/10.1111/j.1464-5491.2011.03563.x
20 https://doi.org/10.1111/j.1742-1241.2009.02171.x
21 https://doi.org/10.1111/j.1742-1241.2009.02262.x
22 https://doi.org/10.1111/j.1742-1241.2011.02797.x
23 https://doi.org/10.1136/bmj.304.6826.521
24 https://doi.org/10.1185/03007995.2011.578245
25 https://doi.org/10.1185/03007995.2011.579951
26 https://doi.org/10.1185/03007995.2012.707119
27 https://doi.org/10.1185/03007995.2013.803054
28 https://doi.org/10.12968/bjcn.2001.6.11.9459
29 https://doi.org/10.2147/dmso.s23261
30 https://doi.org/10.2337/dc10-0896
31 https://doi.org/10.2337/diacare.21.9.1414
32 https://doi.org/10.2337/diacare.27.10.2306
33 https://doi.org/10.2337/diacare.28.2.421
34 https://doi.org/10.2337/diacare.29.03.06.dc05-2102
35 https://doi.org/10.2337/diacare.29.03.06.dc05-2184
36 https://doi.org/10.3810/hp.2012.04.965
37 https://doi.org/10.3810/hp.2013.04.1059
38 https://doi.org/10.4103/2230-8210.97994
39 https://doi.org/10.4103/2230-8210.97996
40 schema:datePublished 2013-12
41 schema:datePublishedReg 2013-12-01
42 schema:description AIM: To assess in real life the rate of hypoglycemia during Ramadan in patients with type 2 diabetes (T2DM) in France, according to their ongoing dual therapy of metformin-vildagliptin or metformin-sulfonylurea/glinide (IS). METHODS: Prospective, non-interventional study with 2 visits (within 8 weeks before and 6 weeks after the end of Ramadan 2012). Study diaries were not used to collect events or record values of glucose monitoring. One hundred and ninety-eight patients on stable oral dual therapy for ≥2 months and with glycosylated hemoglobin (HbA1c) ≤8.0% were recruited by 62 centers: 83 in the IS cohort and 115 in the vildagliptin cohort. RESULTS: Approximately 90% of patients were from Maghreb. The two cohorts were well balanced: 60% men, mean age 59 years, BMI 28 kg/m(2), metformin dose ~2,000 mg/day, and HbA1c 7.2%. Distinct therapeutic management was planned in view of Ramadan with drug-adaptation intended in 61.4% of IS and 18.3% of vildagliptin patients. Hypoglycemia was reported in 37% of IS and 34% of vildagliptin patients; episodes declared as confirmed in 30.8% and 23.5%, respectively, and episodes documented as adverse event (AE) in 17.9% (22 episodes) and 7.5% (13 episodes), respectively (P = 0.025). Severe episodes were reported in 3.9% of IS and 1.7% of vildagliptin patients. 10.4% of IS and 2.6% of vildagliptin patients reported severe episodes and/or unscheduled medical visits due to hypoglycemia (P = 0.029). Glycemic control remained stable in both cohorts. Compliance with fasting was high, as well as adherence to drug with ≥5 missed-dose for 15.4% of IS and 8.5% of vildagliptin patients. CONCLUSION: Although the overall frequency of malaise suggestive of hypoglycemia was high, which would be expected with prolonged fasting in a well-controlled T2DM population during hot summer days, the incidence of more severe and better-documented episodes (AE, severe event, event leading to unscheduled medical visit) were much lower, with consistently less events with vildagliptin therapy.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree true
46 schema:isPartOf N1161a9085b234a3f9a6a7afbe8dd645c
47 N16d517925ba84d90819a1877ca72bb64
48 sg:journal.1044057
49 schema:name Experience with Vildagliptin in Type 2 Diabetic Patients Fasting During Ramadan in France: Insights from the VERDI Study
50 schema:pagination 385-398
51 schema:productId N21e505a558a5421bb2ca77002e208bef
52 N45a3b4be5e92479c82e448e73f611bff
53 N58c86a43a1a94b608832cb2bbed68f80
54 Nbf4c48440dfd405caed7c04e4679a09c
55 Nddecfc8e73b9453fa4f49593746d4e1a
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014993206
57 https://doi.org/10.1007/s13300-013-0038-7
58 schema:sdDatePublished 2019-04-10T15:03
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher N46be783c8e2445db840aa189aa3ff602
61 schema:url http://link.springer.com/10.1007%2Fs13300-013-0038-7
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N1161a9085b234a3f9a6a7afbe8dd645c schema:volumeNumber 4
66 rdf:type schema:PublicationVolume
67 N13d839a10c5046c58ccb5b23c0797cbf rdf:first sg:person.01205660265.81
68 rdf:rest Nc59928fb1e90484ea106214df8d30e29
69 N16d517925ba84d90819a1877ca72bb64 schema:issueNumber 2
70 rdf:type schema:PublicationIssue
71 N21e505a558a5421bb2ca77002e208bef schema:name pubmed_id
72 schema:value 23996548
73 rdf:type schema:PropertyValue
74 N45a3b4be5e92479c82e448e73f611bff schema:name nlm_unique_id
75 schema:value 101539025
76 rdf:type schema:PropertyValue
77 N46be783c8e2445db840aa189aa3ff602 schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N58c86a43a1a94b608832cb2bbed68f80 schema:name doi
80 schema:value 10.1007/s13300-013-0038-7
81 rdf:type schema:PropertyValue
82 N5f02a90f2f80408b8e039ab8442e683c schema:name Department of Diabetology and Endocrinology, Max Fourestier Hospital, Nanterre, France
83 rdf:type schema:Organization
84 N83c3d3f3b73d4ad38ad38215bd6ea2dc rdf:first sg:person.01323162303.56
85 rdf:rest rdf:nil
86 Nbf4c48440dfd405caed7c04e4679a09c schema:name dimensions_id
87 schema:value pub.1014993206
88 rdf:type schema:PropertyValue
89 Nc59928fb1e90484ea106214df8d30e29 rdf:first sg:person.01345244315.30
90 rdf:rest Ne6cf32506e4745f4bc48f8cfa587e846
91 Nddecfc8e73b9453fa4f49593746d4e1a schema:name readcube_id
92 schema:value 476eb785bbb7aed9a50d5263d471ef6d49d04c46b231d0234c198ce8afefdac1
93 rdf:type schema:PropertyValue
94 Ne6cf32506e4745f4bc48f8cfa587e846 rdf:first sg:person.01170602375.40
95 rdf:rest Nf4c63807c97f4036b0b290e7bafe9945
96 Nf4c63807c97f4036b0b290e7bafe9945 rdf:first sg:person.01353144175.45
97 rdf:rest N83c3d3f3b73d4ad38ad38215bd6ea2dc
98 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
99 schema:name Medical and Health Sciences
100 rdf:type schema:DefinedTerm
101 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
102 schema:name Clinical Sciences
103 rdf:type schema:DefinedTerm
104 sg:journal.1044057 schema:issn 1869-6953
105 1869-6961
106 schema:name Diabetes Therapy
107 rdf:type schema:Periodical
108 sg:person.01170602375.40 schema:affiliation https://www.grid.ac/institutes/grid.414363.7
109 schema:familyName Huet
110 schema:givenName Dominique
111 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170602375.40
112 rdf:type schema:Person
113 sg:person.01205660265.81 schema:affiliation https://www.grid.ac/institutes/grid.9621.c
114 schema:familyName Halimi
115 schema:givenName Serge
116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205660265.81
117 rdf:type schema:Person
118 sg:person.01323162303.56 schema:affiliation https://www.grid.ac/institutes/grid.418380.6
119 schema:familyName Dejager
120 schema:givenName Sylvie
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323162303.56
122 rdf:type schema:Person
123 sg:person.01345244315.30 schema:affiliation N5f02a90f2f80408b8e039ab8442e683c
124 schema:familyName Levy
125 schema:givenName Marc
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345244315.30
127 rdf:type schema:Person
128 sg:person.01353144175.45 schema:affiliation https://www.grid.ac/institutes/grid.418380.6
129 schema:familyName Quéré
130 schema:givenName Stéphane
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353144175.45
132 rdf:type schema:Person
133 sg:pub.10.1007/s00125-008-1220-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013840377
134 https://doi.org/10.1007/s00125-008-1220-8
135 rdf:type schema:CreativeWork
136 sg:pub.10.1007/s11096-012-9716-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039702095
137 https://doi.org/10.1007/s11096-012-9716-1
138 rdf:type schema:CreativeWork
139 sg:pub.10.1007/s13300-010-0018-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044900948
140 https://doi.org/10.1007/s13300-010-0018-0
141 rdf:type schema:CreativeWork
142 https://app.dimensions.ai/details/publication/pub.1076844888 schema:CreativeWork
143 https://app.dimensions.ai/details/publication/pub.1077163706 schema:CreativeWork
144 https://doi.org/10.1002/dmrr.1137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012192111
145 rdf:type schema:CreativeWork
146 https://doi.org/10.1016/j.diabet.2010.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002194006
147 rdf:type schema:CreativeWork
148 https://doi.org/10.1016/j.diabet.2012.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043326201
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1016/s0003-4266(04)96003-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037049033
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1016/s0168-8227(02)00104-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023648010
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1111/ijcp.12243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037348712
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1111/j.1463-1326.2008.00994.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036104286
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1111/j.1463-1326.2010.01233.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023139110
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1111/j.1463-1326.2010.01325.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011802425
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1111/j.1464-5491.2010.02948.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027050111
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1111/j.1464-5491.2011.03563.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008055608
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1111/j.1742-1241.2009.02171.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022078283
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1111/j.1742-1241.2009.02262.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050288641
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1111/j.1742-1241.2011.02797.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011105045
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1136/bmj.304.6826.521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037707159
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1185/03007995.2011.578245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012851198
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1185/03007995.2011.579951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024380810
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1185/03007995.2012.707119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037645721
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1185/03007995.2013.803054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048319643
181 rdf:type schema:CreativeWork
182 https://doi.org/10.12968/bjcn.2001.6.11.9459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064774525
183 rdf:type schema:CreativeWork
184 https://doi.org/10.2147/dmso.s23261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050800747
185 rdf:type schema:CreativeWork
186 https://doi.org/10.2337/dc10-0896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029324537
187 rdf:type schema:CreativeWork
188 https://doi.org/10.2337/diacare.21.9.1414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070748416
189 rdf:type schema:CreativeWork
190 https://doi.org/10.2337/diacare.27.10.2306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052498569
191 rdf:type schema:CreativeWork
192 https://doi.org/10.2337/diacare.28.2.421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052905869
193 rdf:type schema:CreativeWork
194 https://doi.org/10.2337/diacare.29.03.06.dc05-2102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019091258
195 rdf:type schema:CreativeWork
196 https://doi.org/10.2337/diacare.29.03.06.dc05-2184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045125907
197 rdf:type schema:CreativeWork
198 https://doi.org/10.3810/hp.2012.04.965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071437585
199 rdf:type schema:CreativeWork
200 https://doi.org/10.3810/hp.2013.04.1059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071437648
201 rdf:type schema:CreativeWork
202 https://doi.org/10.4103/2230-8210.97994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009800199
203 rdf:type schema:CreativeWork
204 https://doi.org/10.4103/2230-8210.97996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047652860
205 rdf:type schema:CreativeWork
206 https://www.grid.ac/institutes/grid.414363.7 schema:alternateName Hôpital Saint-Joseph
207 schema:name Department of Diabetology and Endocrinology, Saint-Joseph Hospital, Paris, France
208 rdf:type schema:Organization
209 https://www.grid.ac/institutes/grid.418380.6 schema:alternateName Novartis (France)
210 schema:name Biostatistics, Novartis Pharma SAS, Rueil Malmaison, France
211 Medical Affairs, Novartis Pharma SAS, 2-4 rue Lionel Terray, 92 506, Rueil Malmaison, France
212 rdf:type schema:Organization
213 https://www.grid.ac/institutes/grid.9621.c schema:alternateName Joseph Fourier University
214 schema:name Department of Diabetology, Endocrinology and Nutrition, CHU Hospital Grenoble, and University Joseph Fourier, Grenoble, France
215 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...