Regulation of autophagy by Ca2+ View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Fang Sun, Xia Xu, Xiaohong Wang, Bei Zhang

ABSTRACT

Autophagy is an evolutionarily conserved lysosomal catabolic process used as an internal engine in response to nutrient starvation or metabolic stress. A number of protein complexes and an intricate network of stress signaling cascades impinge on the regulation of autophagy; the mammalian target of rapamycin serves as a canonical player. Ca2+, as a major intracellular second messenger, regulates multiple physiological and pathological functions. Although significant information is already well-established about the role of Ca2+ in apoptosis, its role in autophagy has been recently determined and is poorly understood. Intracellular Ca2+ positively and negatively affects autophagy. In this review, evidence for both views and the interplay of Ca2+ between autophagy and apoptosis induction are discussed. The available data revealed the bidirectional role of Ca2+ in the regulation of autophagy. Moreover, the data also indicated that this role probably depends on the context of time, space, Ca2+ source, and cell state, thus either preventing or enhancing autophagy. More... »

PAGES

15467-15476

References to SciGraph publications

  • 2000-10. The versatility and universality of calcium signalling in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2010-03. S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3 in CELL RESEARCH
  • 2009-07. The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1 in CELL DEATH & DIFFERENTIATION
  • 2007-05. Regulation of autophagy by the inositol trisphosphate receptor in CELL DEATH & DIFFERENTIATION
  • 2003-07. Calcium signalling: dynamics, homeostasis and remodelling in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2009-05. Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function in ONCOGENE
  • 2006-10. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis in NATURE CELL BIOLOGY
  • 2008-05. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway in NATURE CHEMICAL BIOLOGY
  • 2015-03. Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB in NATURE CELL BIOLOGY
  • 2010-09. Autophagy in mammalian development and differentiation in NATURE CELL BIOLOGY
  • 2008-10. Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis in ONCOGENE
  • 2007-10. Autophagosome formation: core machinery and adaptations in NATURE CELL BIOLOGY
  • 2005-12. Molecular mechanism and regulation of autophagy in ACTA PHARMACOLOGICA SINICA
  • 2008-11. Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2009-09. Bergmann Glial S100B Activates Myo-inositol Monophosphatase 1 and Co-localizes to Purkinje Cell Vacuoles in SCA1 Transgenic Mice in THE CEREBELLUM
  • 2012-01. Autophagy: for better or for worse in CELL RESEARCH
  • 2007-10. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2010-01. Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria in CELL DEATH & DISEASE
  • 2009-08. Intracellular protein degradation in mammalian cells: recent developments in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2007-10. Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein in CELL RESEARCH
  • Journal

    TITLE

    Tumor Biology

    ISSUE

    12

    VOLUME

    37

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13277-016-5353-y

    DOI

    http://dx.doi.org/10.1007/s13277-016-5353-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042191730

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27864685


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Xuzhou Central Hospital", 
              "id": "https://www.grid.ac/institutes/grid.452207.6", 
              "name": [
                "Department of Clinical Medicine, Xuzhou Medical University, 221000, Xuzhou, Jiangsu, China", 
                "Department of Obstetrics and Gynecology, Xuzhou Central Hospital, 221009, Xuzhou, Jiangsu, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sun", 
            "givenName": "Fang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Obstetrics and Gynecology, Xuzhou Hospital of Traditional Chinese Medicine, 221002, Xuzhou, Jiangsu, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xu", 
            "givenName": "Xia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Obstetrics and Gynecology, Xuzhou Hospital of Traditional Chinese Medicine, 221002, Xuzhou, Jiangsu, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Xiaohong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Xuzhou Central Hospital", 
              "id": "https://www.grid.ac/institutes/grid.452207.6", 
              "name": [
                "Department of Clinical Medicine, Xuzhou Medical University, 221000, Xuzhou, Jiangsu, China", 
                "Department of Obstetrics and Gynecology, Xuzhou Central Hospital, 221009, Xuzhou, Jiangsu, China", 
                "Department of Obstetrics and Gynecology, Xuzhou Central Hospital, 221002, Xuzhou, Jiangsu, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Bei", 
            "id": "sg:person.01352465372.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352465372.30"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.4061/2011/920178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000330518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001081236", 
              "https://doi.org/10.1038/onc.2008.308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001623057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.184325.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002827936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4402099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003768744", 
              "https://doi.org/10.1038/sj.cdd.4402099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4402099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003768744", 
              "https://doi.org/10.1038/sj.cdd.4402099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceca.2009.12.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003996926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2009.369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005698469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2006.12.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006569516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.25.3.1025-1040.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006740658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m506736200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006940241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2011.09.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007660119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008244448", 
              "https://doi.org/10.1038/ncb3114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2011.10.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010173873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/cells1030284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013535818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cellsig.2010.01.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013971435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2011.152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014458082", 
              "https://doi.org/10.1038/cr.2011.152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceca.2010.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014702442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.12.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015281436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m112.365767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015652013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1254/jphs.11181fp", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016200824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2004.11.046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016273873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceb.2009.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016557330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a005579", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017719632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12311-009-0125-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018956860", 
              "https://doi.org/10.1007/s12311-009-0125-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12311-009-0125-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018956860", 
              "https://doi.org/10.1007/s12311-009-0125-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019075708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019075708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceca.2011.04.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019875221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1007-1102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021106053", 
              "https://doi.org/10.1038/ncb1007-1102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021292551", 
              "https://doi.org/10.1038/nrm2249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2005.11.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022003052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.114207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022424690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200911078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023296954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2009.129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023299195", 
              "https://doi.org/10.1038/cr.2009.129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023407245", 
              "https://doi.org/10.1038/35036035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023407245", 
              "https://doi.org/10.1038/35036035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023407245", 
              "https://doi.org/10.1038/35036035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20030527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023726354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.2436255100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024287442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-291x(03)00616-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024506152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-291x(03)00616-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024506152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2009.60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025613102", 
              "https://doi.org/10.1038/onc.2009.60"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2009.60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025613102", 
              "https://doi.org/10.1038/onc.2009.60"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m804723200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026513542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2010.01.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026525305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2013.11.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027760506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddr481", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028519314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)00929-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029247539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-009-0030-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030704899", 
              "https://doi.org/10.1007/s00018-009-0030-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-009-0030-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030704899", 
              "https://doi.org/10.1007/s00018-009-0030-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-009-0030-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030704899", 
              "https://doi.org/10.1007/s00018-009-0030-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3120955", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032197660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3120955", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032197660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2009.16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033044417", 
              "https://doi.org/10.1038/cddis.2009.16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2009.16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033044417", 
              "https://doi.org/10.1038/cddis.2009.16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200504035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035218241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2007.78", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037118993", 
              "https://doi.org/10.1038/cr.2007.78"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.6.7.13290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037422173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1745-7254.2005.00235.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038205426", 
              "https://doi.org/10.1111/j.1745-7254.2005.00235.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1745-7254.2005.00235.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038205426", 
              "https://doi.org/10.1111/j.1745-7254.2005.00235.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2011.11.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038660278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m710209200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038675516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1212704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040020285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.05-4305fje", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040117665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1534-5807(04)00099-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040769254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.79", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041084532", 
              "https://doi.org/10.1038/nchembio.79"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e07-08-0823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042010794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.06.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042171275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-09-0700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042523850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.00030.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042618522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.21.17.5742-5752.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043118668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.06159-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043581162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceca.2012.03.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044152945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbamcr.2010.11.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044872236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-008-8383-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044959798", 
              "https://doi.org/10.1007/s00018-008-8383-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045025068", 
              "https://doi.org/10.1038/ncb1482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045025068", 
              "https://doi.org/10.1038/ncb1482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045139557", 
              "https://doi.org/10.1038/nrm1155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045139557", 
              "https://doi.org/10.1038/nrm1155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2009.34", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045784036", 
              "https://doi.org/10.1038/cdd.2009.34"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1742-4658.2007.05849.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046649239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1534-5807(03)00296-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047655270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.060061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048552413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1002664", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048823922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2011.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050816617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb0910-823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051165995", 
              "https://doi.org/10.1038/ncb0910-823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb0910-823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051165995", 
              "https://doi.org/10.1038/ncb0910-823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00166-09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051726150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-cellbio-092910-154005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052438773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/embor.2008.246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053565207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000261924.76669.36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053715163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000261924.76669.36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053715163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/340731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058638742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/abbs/gmv096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059352812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.2015.3103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071514008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.2015.3103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071514008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.25367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072289796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.4713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072290246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.5.5.8625", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072290413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.6.1.10326", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072290607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.6.5.11964", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072290709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.6.8.13337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072290787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.6360", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072290839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.7.12.17909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072290964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078545310", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082723339", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-12", 
        "datePublishedReg": "2016-12-01", 
        "description": "Autophagy is an evolutionarily conserved lysosomal catabolic process used as an internal engine in response to nutrient starvation or metabolic stress. A number of protein complexes and an intricate network of stress signaling cascades impinge on the regulation of autophagy; the mammalian target of rapamycin serves as a canonical player. Ca2+, as a major intracellular second messenger, regulates multiple physiological and pathological functions. Although significant information is already well-established about the role of Ca2+ in apoptosis, its role in autophagy has been recently determined and is poorly understood. Intracellular Ca2+ positively and negatively affects autophagy. In this review, evidence for both views and the interplay of Ca2+ between autophagy and apoptosis induction are discussed. The available data revealed the bidirectional role of Ca2+ in the regulation of autophagy. Moreover, the data also indicated that this role probably depends on the context of time, space, Ca2+ source, and cell state, thus either preventing or enhancing autophagy.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s13277-016-5353-y", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1091981", 
            "issn": [
              "1010-4283", 
              "1423-0380"
            ], 
            "name": "Tumor Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "12", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "37"
          }
        ], 
        "name": "Regulation of autophagy by Ca2+", 
        "pagination": "15467-15476", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c8fb0eb884fc26f5bb5e500c9b001646e698ef9370cd9dff9278b0a6904fd140"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27864685"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8409922"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s13277-016-5353-y"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1042191730"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s13277-016-5353-y", 
          "https://app.dimensions.ai/details/publication/pub.1042191730"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:44", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70068_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs13277-016-5353-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13277-016-5353-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13277-016-5353-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13277-016-5353-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13277-016-5353-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    381 TRIPLES      21 PREDICATES      119 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s13277-016-5353-y schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author Nb5917fe2496d4891bd6b92c261b3009e
    4 schema:citation sg:pub.10.1007/s00018-008-8383-9
    5 sg:pub.10.1007/s00018-009-0030-6
    6 sg:pub.10.1007/s12311-009-0125-5
    7 sg:pub.10.1038/35036035
    8 sg:pub.10.1038/cdd.2009.34
    9 sg:pub.10.1038/cddis.2009.16
    10 sg:pub.10.1038/cr.2007.78
    11 sg:pub.10.1038/cr.2009.129
    12 sg:pub.10.1038/cr.2011.152
    13 sg:pub.10.1038/ncb0910-823
    14 sg:pub.10.1038/ncb1007-1102
    15 sg:pub.10.1038/ncb1482
    16 sg:pub.10.1038/ncb3114
    17 sg:pub.10.1038/nchembio.79
    18 sg:pub.10.1038/nrm1155
    19 sg:pub.10.1038/nrm2249
    20 sg:pub.10.1038/onc.2008.308
    21 sg:pub.10.1038/onc.2009.60
    22 sg:pub.10.1038/sj.cdd.4402099
    23 sg:pub.10.1111/j.1745-7254.2005.00235.x
    24 https://app.dimensions.ai/details/publication/pub.1078545310
    25 https://app.dimensions.ai/details/publication/pub.1082723339
    26 https://doi.org/10.1016/j.bbamcr.2010.11.023
    27 https://doi.org/10.1016/j.bbrc.2013.11.044
    28 https://doi.org/10.1016/j.ceb.2009.11.004
    29 https://doi.org/10.1016/j.ceca.2009.12.013
    30 https://doi.org/10.1016/j.ceca.2010.02.001
    31 https://doi.org/10.1016/j.ceca.2011.04.001
    32 https://doi.org/10.1016/j.ceca.2012.03.001
    33 https://doi.org/10.1016/j.cell.2004.11.046
    34 https://doi.org/10.1016/j.cell.2005.07.002
    35 https://doi.org/10.1016/j.cell.2007.12.018
    36 https://doi.org/10.1016/j.cell.2010.06.007
    37 https://doi.org/10.1016/j.cellsig.2010.01.015
    38 https://doi.org/10.1016/j.cmet.2011.04.004
    39 https://doi.org/10.1016/j.cub.2011.11.034
    40 https://doi.org/10.1016/j.febslet.2010.01.017
    41 https://doi.org/10.1016/j.molcel.2006.12.009
    42 https://doi.org/10.1016/j.molcel.2008.06.001
    43 https://doi.org/10.1016/j.neurobiolaging.2011.09.039
    44 https://doi.org/10.1016/j.tibs.2005.11.009
    45 https://doi.org/10.1016/j.yjmcc.2011.10.018
    46 https://doi.org/10.1016/s0006-291x(03)00616-8
    47 https://doi.org/10.1016/s0092-8674(03)00929-2
    48 https://doi.org/10.1016/s1534-5807(03)00296-x
    49 https://doi.org/10.1016/s1534-5807(04)00099-1
    50 https://doi.org/10.1038/emboj.2009.369
    51 https://doi.org/10.1038/embor.2008.246
    52 https://doi.org/10.1042/bj3120955
    53 https://doi.org/10.1073/pnas.2436255100
    54 https://doi.org/10.1074/jbc.m109.060061
    55 https://doi.org/10.1074/jbc.m110.114207
    56 https://doi.org/10.1074/jbc.m112.365767
    57 https://doi.org/10.1074/jbc.m506736200
    58 https://doi.org/10.1074/jbc.m710209200
    59 https://doi.org/10.1074/jbc.m804723200
    60 https://doi.org/10.1083/jcb.200504035
    61 https://doi.org/10.1083/jcb.200911078
    62 https://doi.org/10.1084/jem.20030527
    63 https://doi.org/10.1086/340731
    64 https://doi.org/10.1091/mbc.e07-08-0823
    65 https://doi.org/10.1093/abbs/gmv096
    66 https://doi.org/10.1093/hmg/ddr481
    67 https://doi.org/10.1096/fj.05-4305fje
    68 https://doi.org/10.1101/cshperspect.a005579
    69 https://doi.org/10.1101/gad.1212704
    70 https://doi.org/10.1101/gad.184325.111
    71 https://doi.org/10.1111/j.1742-4658.2007.05849.x
    72 https://doi.org/10.1128/mcb.00166-09
    73 https://doi.org/10.1128/mcb.06159-11
    74 https://doi.org/10.1128/mcb.21.17.5742-5752.2001
    75 https://doi.org/10.1128/mcb.25.3.1025-1040.2005
    76 https://doi.org/10.1146/annurev-cellbio-092910-154005
    77 https://doi.org/10.1152/physrev.00030.2009
    78 https://doi.org/10.1158/1535-7163.mct-09-0700
    79 https://doi.org/10.1161/01.res.0000261924.76669.36
    80 https://doi.org/10.1254/jphs.11181fp
    81 https://doi.org/10.1371/journal.ppat.1002664
    82 https://doi.org/10.3390/cells1030284
    83 https://doi.org/10.3892/ijo.2015.3103
    84 https://doi.org/10.4061/2011/920178
    85 https://doi.org/10.4161/auto.25367
    86 https://doi.org/10.4161/auto.4713
    87 https://doi.org/10.4161/auto.5.5.8625
    88 https://doi.org/10.4161/auto.6.1.10326
    89 https://doi.org/10.4161/auto.6.5.11964
    90 https://doi.org/10.4161/auto.6.7.13290
    91 https://doi.org/10.4161/auto.6.8.13337
    92 https://doi.org/10.4161/auto.6360
    93 https://doi.org/10.4161/auto.7.12.17909
    94 schema:datePublished 2016-12
    95 schema:datePublishedReg 2016-12-01
    96 schema:description Autophagy is an evolutionarily conserved lysosomal catabolic process used as an internal engine in response to nutrient starvation or metabolic stress. A number of protein complexes and an intricate network of stress signaling cascades impinge on the regulation of autophagy; the mammalian target of rapamycin serves as a canonical player. Ca<sup>2+</sup>, as a major intracellular second messenger, regulates multiple physiological and pathological functions. Although significant information is already well-established about the role of Ca<sup>2+</sup> in apoptosis, its role in autophagy has been recently determined and is poorly understood. Intracellular Ca<sup>2+</sup> positively and negatively affects autophagy. In this review, evidence for both views and the interplay of Ca<sup>2+</sup> between autophagy and apoptosis induction are discussed. The available data revealed the bidirectional role of Ca<sup>2+</sup> in the regulation of autophagy. Moreover, the data also indicated that this role probably depends on the context of time, space, Ca<sup>2+</sup> source, and cell state, thus either preventing or enhancing autophagy.
    97 schema:genre research_article
    98 schema:inLanguage en
    99 schema:isAccessibleForFree true
    100 schema:isPartOf N51c2f64989d640b694c255580121b196
    101 N646866207e3d486cb145247dccf53eb7
    102 sg:journal.1091981
    103 schema:name Regulation of autophagy by Ca2+
    104 schema:pagination 15467-15476
    105 schema:productId N304593e36b77405f893036a17ff34f86
    106 N35cf1532a5c64274be3bfeba620b1da2
    107 N4eeac85bfd964d7b96033525922ba4a5
    108 Nb92396f7094145bcbf8eaec6d3d8d7a2
    109 Nebc1537e42c34e9cb13a80f72d1fe96e
    110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042191730
    111 https://doi.org/10.1007/s13277-016-5353-y
    112 schema:sdDatePublished 2019-04-11T12:44
    113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    114 schema:sdPublisher Nb1fe789ab8a743e1b82ddb658e2a4173
    115 schema:url https://link.springer.com/10.1007%2Fs13277-016-5353-y
    116 sgo:license sg:explorer/license/
    117 sgo:sdDataset articles
    118 rdf:type schema:ScholarlyArticle
    119 N032dfc99053d46f1b49522b0a2844d78 rdf:first N98c34243eff64fbda3c661252880fc40
    120 rdf:rest Na1367099dfcb4cc7be4471b083e2bc38
    121 N05e97d56a1ca40008411b45ce9345284 rdf:first sg:person.01352465372.30
    122 rdf:rest rdf:nil
    123 N0e87e83ccf3c4649be247a1923d7b215 schema:affiliation https://www.grid.ac/institutes/grid.452207.6
    124 schema:familyName Sun
    125 schema:givenName Fang
    126 rdf:type schema:Person
    127 N304593e36b77405f893036a17ff34f86 schema:name pubmed_id
    128 schema:value 27864685
    129 rdf:type schema:PropertyValue
    130 N35cf1532a5c64274be3bfeba620b1da2 schema:name doi
    131 schema:value 10.1007/s13277-016-5353-y
    132 rdf:type schema:PropertyValue
    133 N4eeac85bfd964d7b96033525922ba4a5 schema:name readcube_id
    134 schema:value c8fb0eb884fc26f5bb5e500c9b001646e698ef9370cd9dff9278b0a6904fd140
    135 rdf:type schema:PropertyValue
    136 N51c2f64989d640b694c255580121b196 schema:issueNumber 12
    137 rdf:type schema:PublicationIssue
    138 N646866207e3d486cb145247dccf53eb7 schema:volumeNumber 37
    139 rdf:type schema:PublicationVolume
    140 N7bfcf00212324580b14852aae952cfd2 schema:name Department of Obstetrics and Gynecology, Xuzhou Hospital of Traditional Chinese Medicine, 221002, Xuzhou, Jiangsu, China
    141 rdf:type schema:Organization
    142 N98c34243eff64fbda3c661252880fc40 schema:affiliation N7bfcf00212324580b14852aae952cfd2
    143 schema:familyName Xu
    144 schema:givenName Xia
    145 rdf:type schema:Person
    146 Na1367099dfcb4cc7be4471b083e2bc38 rdf:first Nfc1a72a4696f4b24924d584b5e254bef
    147 rdf:rest N05e97d56a1ca40008411b45ce9345284
    148 Nb1fe789ab8a743e1b82ddb658e2a4173 schema:name Springer Nature - SN SciGraph project
    149 rdf:type schema:Organization
    150 Nb5917fe2496d4891bd6b92c261b3009e rdf:first N0e87e83ccf3c4649be247a1923d7b215
    151 rdf:rest N032dfc99053d46f1b49522b0a2844d78
    152 Nb92396f7094145bcbf8eaec6d3d8d7a2 schema:name nlm_unique_id
    153 schema:value 8409922
    154 rdf:type schema:PropertyValue
    155 Nddee4b73e11e4b0b84b7821e47627905 schema:name Department of Obstetrics and Gynecology, Xuzhou Hospital of Traditional Chinese Medicine, 221002, Xuzhou, Jiangsu, China
    156 rdf:type schema:Organization
    157 Nebc1537e42c34e9cb13a80f72d1fe96e schema:name dimensions_id
    158 schema:value pub.1042191730
    159 rdf:type schema:PropertyValue
    160 Nfc1a72a4696f4b24924d584b5e254bef schema:affiliation Nddee4b73e11e4b0b84b7821e47627905
    161 schema:familyName Wang
    162 schema:givenName Xiaohong
    163 rdf:type schema:Person
    164 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    165 schema:name Biological Sciences
    166 rdf:type schema:DefinedTerm
    167 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    168 schema:name Biochemistry and Cell Biology
    169 rdf:type schema:DefinedTerm
    170 sg:journal.1091981 schema:issn 1010-4283
    171 1423-0380
    172 schema:name Tumor Biology
    173 rdf:type schema:Periodical
    174 sg:person.01352465372.30 schema:affiliation https://www.grid.ac/institutes/grid.452207.6
    175 schema:familyName Zhang
    176 schema:givenName Bei
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352465372.30
    178 rdf:type schema:Person
    179 sg:pub.10.1007/s00018-008-8383-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044959798
    180 https://doi.org/10.1007/s00018-008-8383-9
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1007/s00018-009-0030-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030704899
    183 https://doi.org/10.1007/s00018-009-0030-6
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1007/s12311-009-0125-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018956860
    186 https://doi.org/10.1007/s12311-009-0125-5
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1038/35036035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023407245
    189 https://doi.org/10.1038/35036035
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1038/cdd.2009.34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045784036
    192 https://doi.org/10.1038/cdd.2009.34
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1038/cddis.2009.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033044417
    195 https://doi.org/10.1038/cddis.2009.16
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1038/cr.2007.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037118993
    198 https://doi.org/10.1038/cr.2007.78
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/cr.2009.129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023299195
    201 https://doi.org/10.1038/cr.2009.129
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/cr.2011.152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014458082
    204 https://doi.org/10.1038/cr.2011.152
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/ncb0910-823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051165995
    207 https://doi.org/10.1038/ncb0910-823
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/ncb1007-1102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021106053
    210 https://doi.org/10.1038/ncb1007-1102
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/ncb1482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045025068
    213 https://doi.org/10.1038/ncb1482
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/ncb3114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008244448
    216 https://doi.org/10.1038/ncb3114
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/nchembio.79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041084532
    219 https://doi.org/10.1038/nchembio.79
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/nrm1155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045139557
    222 https://doi.org/10.1038/nrm1155
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/nrm2249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021292551
    225 https://doi.org/10.1038/nrm2249
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/onc.2008.308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001081236
    228 https://doi.org/10.1038/onc.2008.308
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/onc.2009.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025613102
    231 https://doi.org/10.1038/onc.2009.60
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/sj.cdd.4402099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003768744
    234 https://doi.org/10.1038/sj.cdd.4402099
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1111/j.1745-7254.2005.00235.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038205426
    237 https://doi.org/10.1111/j.1745-7254.2005.00235.x
    238 rdf:type schema:CreativeWork
    239 https://app.dimensions.ai/details/publication/pub.1078545310 schema:CreativeWork
    240 https://app.dimensions.ai/details/publication/pub.1082723339 schema:CreativeWork
    241 https://doi.org/10.1016/j.bbamcr.2010.11.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044872236
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/j.bbrc.2013.11.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027760506
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/j.ceb.2009.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016557330
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.ceca.2009.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003996926
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.ceca.2010.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014702442
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.ceca.2011.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019875221
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.ceca.2012.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044152945
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.cell.2004.11.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016273873
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.cell.2005.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019075708
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.cell.2007.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015281436
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.cell.2010.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042171275
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.cellsig.2010.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013971435
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/j.cmet.2011.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050816617
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/j.cub.2011.11.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038660278
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.febslet.2010.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026525305
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.molcel.2006.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006569516
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/j.molcel.2008.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001623057
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.neurobiolaging.2011.09.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007660119
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.tibs.2005.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022003052
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.yjmcc.2011.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010173873
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/s0006-291x(03)00616-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024506152
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/s0092-8674(03)00929-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029247539
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/s1534-5807(03)00296-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047655270
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/s1534-5807(04)00099-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040769254
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1038/emboj.2009.369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005698469
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1038/embor.2008.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053565207
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1042/bj3120955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032197660
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1073/pnas.2436255100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024287442
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1074/jbc.m109.060061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048552413
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1074/jbc.m110.114207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022424690
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1074/jbc.m112.365767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015652013
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1074/jbc.m506736200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006940241
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1074/jbc.m710209200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038675516
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1074/jbc.m804723200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026513542
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1083/jcb.200504035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035218241
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1083/jcb.200911078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023296954
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1084/jem.20030527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023726354
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1086/340731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058638742
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1091/mbc.e07-08-0823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042010794
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1093/abbs/gmv096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059352812
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1093/hmg/ddr481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028519314
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1096/fj.05-4305fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1040117665
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1101/cshperspect.a005579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017719632
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1101/gad.1212704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040020285
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1101/gad.184325.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002827936
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1111/j.1742-4658.2007.05849.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046649239
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1128/mcb.00166-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051726150
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1128/mcb.06159-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043581162
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1128/mcb.21.17.5742-5752.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043118668
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1128/mcb.25.3.1025-1040.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006740658
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1146/annurev-cellbio-092910-154005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052438773
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1152/physrev.00030.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042618522
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1158/1535-7163.mct-09-0700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042523850
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1161/01.res.0000261924.76669.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053715163
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1254/jphs.11181fp schema:sameAs https://app.dimensions.ai/details/publication/pub.1016200824
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1371/journal.ppat.1002664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048823922
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.3390/cells1030284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013535818
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.3892/ijo.2015.3103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071514008
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.4061/2011/920178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000330518
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.4161/auto.25367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072289796
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.4161/auto.4713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290246
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.4161/auto.5.5.8625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290413
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.4161/auto.6.1.10326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290607
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.4161/auto.6.5.11964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290709
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.4161/auto.6.7.13290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037422173
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.4161/auto.6.8.13337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290787
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.4161/auto.6360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290839
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.4161/auto.7.12.17909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290964
    376 rdf:type schema:CreativeWork
    377 https://www.grid.ac/institutes/grid.452207.6 schema:alternateName Xuzhou Central Hospital
    378 schema:name Department of Clinical Medicine, Xuzhou Medical University, 221000, Xuzhou, Jiangsu, China
    379 Department of Obstetrics and Gynecology, Xuzhou Central Hospital, 221002, Xuzhou, Jiangsu, China
    380 Department of Obstetrics and Gynecology, Xuzhou Central Hospital, 221009, Xuzhou, Jiangsu, China
    381 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...