The suppressor of cytokine signaling 2 (SOCS2) inhibits tumor metastasis in hepatocellular carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07-28

AUTHORS

Meiling Cui, Ji Sun, Jianjing Hou, Tao Fang, Xin Wang, Chao Ge, Fangyu Zhao, Taoyang Chen, Haiyang Xie, Ying Cui, Ming Yao, Jinjun Li, Hong Li

ABSTRACT

Hepatocellular carcinoma (HCC) is a common cause of cancer-related death worldwide, and its incidence continues to increase. However, the mechanism underlying the development and progression of HCC remains unknown. The suppressor of cytokine signaling 2 (SOCS2) is a member of the SOCS family and influences the carcinogenesis of multiple types of tumors, but the biological roles of SOCS2 in HCC remain unclear. In this study, we found that SOCS2 expression was reduced in HCC tissues compared with matched noncancerous liver tissues. Moreover, decreased SOCS2 expression was significantly associated with the presence of intrahepatic metastasis and high histological grade in HCC patients. Colony formation assays and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays demonstrated that overexpression of SOCS2 or knockdown of endogenous SOCS2 did not significantly affect cell proliferation and tumorigenicity in HCC cells in vitro and in vivo. However, SOCS2 overexpression significantly inhibited the migration and invasion of HCC cells in vitro and inhibited metastasis in vivo. Consistent with these findings, the knockdown of endogenous SOCS2 enhanced migration and invasion in HCC cells in vitro. Our study demonstrated that SOCS2 inhibited human HCC metastasis, and SOCS2 might provide a new potential therapeutic strategy for treating HCC. More... »

PAGES

13521-13531

Journal

TITLE

Tumor Biology

ISSUE

10

VOLUME

37

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13277-016-5215-7

DOI

http://dx.doi.org/10.1007/s13277-016-5215-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048756165

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27465557


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Hepatocellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Grading", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Suppressor of Cytokine Signaling Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.415869.7", 
          "name": [
            "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cui", 
        "givenName": "Meiling", 
        "id": "sg:person.0705637021.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705637021.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai Medical College, Fudan University, 200032, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Shanghai Medical College, Fudan University, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Ji", 
        "id": "sg:person.0753752221.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753752221.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.415869.7", 
          "name": [
            "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hou", 
        "givenName": "Jianjing", 
        "id": "sg:person.012442231175.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012442231175.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.415869.7", 
          "name": [
            "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fang", 
        "givenName": "Tao", 
        "id": "sg:person.0637523621.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637523621.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai Medical College, Fudan University, 200032, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Shanghai Medical College, Fudan University, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Xin", 
        "id": "sg:person.011161037625.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011161037625.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.415869.7", 
          "name": [
            "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ge", 
        "givenName": "Chao", 
        "id": "sg:person.01160767752.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160767752.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.415869.7", 
          "name": [
            "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Fangyu", 
        "id": "sg:person.01333521256.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333521256.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Qi Dong Liver Cancer Institute, 226200, Qi Dong, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Qi Dong Liver Cancer Institute, 226200, Qi Dong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Taoyang", 
        "id": "sg:person.013162461177.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013162461177.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, 310003, Hangzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Department of General Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, 310003, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xie", 
        "givenName": "Haiyang", 
        "id": "sg:person.0657720126.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657720126.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Institute of Guangxi, 530027, Nanning, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Cancer Institute of Guangxi, 530027, Nanning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cui", 
        "givenName": "Ying", 
        "id": "sg:person.01134435204.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134435204.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.415869.7", 
          "name": [
            "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yao", 
        "givenName": "Ming", 
        "id": "sg:person.01330252676.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330252676.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.415869.7", 
          "name": [
            "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Jinjun", 
        "id": "sg:person.01275216352.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275216352.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.415869.7", 
          "name": [
            "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Hong", 
        "id": "sg:person.0625153671.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625153671.44"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1207787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040948254", 
          "https://doi.org/10.1038/sj.onc.1207787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033591106", 
          "https://doi.org/10.1038/sj.onc.1205726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010853272", 
          "https://doi.org/10.1038/nri2093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0501-29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003632653", 
          "https://doi.org/10.1038/ng0501-29"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041084218", 
          "https://doi.org/10.1038/sj.onc.1208788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-013-1599-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024502994", 
          "https://doi.org/10.1007/s11010-013-1599-5"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-07-28", 
    "datePublishedReg": "2016-07-28", 
    "description": "Hepatocellular carcinoma (HCC) is a common cause of cancer-related death worldwide, and its incidence continues to increase. However, the mechanism underlying the development and progression of HCC remains unknown. The suppressor of cytokine signaling 2 (SOCS2) is a member of the SOCS family and influences the carcinogenesis of multiple types of tumors, but the biological roles of SOCS2 in HCC remain unclear. In this study, we found that SOCS2 expression was reduced in HCC tissues compared with matched noncancerous liver tissues. Moreover, decreased SOCS2 expression was significantly associated with the presence of intrahepatic metastasis and high histological grade in HCC patients. Colony formation assays and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays demonstrated that overexpression of SOCS2 or knockdown of endogenous SOCS2 did not significantly affect cell proliferation and tumorigenicity in HCC cells in vitro and in vivo. However, SOCS2 overexpression significantly inhibited the migration and invasion of HCC cells in vitro and inhibited metastasis in vivo. Consistent with these findings, the knockdown of endogenous SOCS2 enhanced migration and invasion in HCC cells in vitro. Our study demonstrated that SOCS2 inhibited human HCC metastasis, and SOCS2 might provide a new potential therapeutic strategy for treating HCC.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s13277-016-5215-7", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8333596", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7014187", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1091981", 
        "issn": [
          "1010-4283", 
          "1423-0380"
        ], 
        "name": "Tumor Biology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "37"
      }
    ], 
    "keywords": [
      "hepatocellular carcinoma", 
      "HCC cells", 
      "suppressor of cytokine", 
      "SOCS2 expression", 
      "new potential therapeutic strategy", 
      "high histological grade", 
      "progression of HCC", 
      "cancer-related death", 
      "potential therapeutic strategy", 
      "noncancerous liver tissues", 
      "colony formation assays", 
      "overexpression of SOCS2", 
      "diphenyltetrazolium bromide assay", 
      "histological grade", 
      "HCC patients", 
      "common cause", 
      "intrahepatic metastasis", 
      "therapeutic strategies", 
      "inhibited metastasis", 
      "human HCC metastasis", 
      "HCC tissues", 
      "metastasis", 
      "HCC metastasis", 
      "liver tissue", 
      "formation assays", 
      "tumor metastasis", 
      "SOCS2 overexpression", 
      "bromide assay", 
      "dimethylthiazol-2", 
      "cell proliferation", 
      "carcinoma", 
      "cytokines", 
      "SOCS2", 
      "vitro", 
      "vivo", 
      "knockdown", 
      "invasion", 
      "tissue", 
      "cells", 
      "overexpression", 
      "biological role", 
      "assays", 
      "patients", 
      "SOCS family", 
      "suppressor", 
      "expression", 
      "tumors", 
      "incidence", 
      "progression", 
      "carcinogenesis", 
      "death", 
      "tumorigenicity", 
      "cause", 
      "proliferation", 
      "study", 
      "multiple types", 
      "grade", 
      "migration", 
      "findings", 
      "role", 
      "presence", 
      "mechanism", 
      "family", 
      "development", 
      "members", 
      "strategies", 
      "types"
    ], 
    "name": "The suppressor of cytokine signaling 2 (SOCS2) inhibits tumor metastasis in hepatocellular carcinoma", 
    "pagination": "13521-13531", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048756165"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13277-016-5215-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27465557"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13277-016-5215-7", 
      "https://app.dimensions.ai/details/publication/pub.1048756165"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_709.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s13277-016-5215-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13277-016-5215-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13277-016-5215-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13277-016-5215-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13277-016-5215-7'


 

This table displays all metadata directly associated to this object as RDF triples.

383 TRIPLES      21 PREDICATES      131 URIs      117 LITERALS      40 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13277-016-5215-7 schema:about N030ac7f629d14b1bad3aa49ad8dc28a8
2 N2432b2513b96411eaca72cc4e2daac25
3 N265eb4e45ad749d68dd356faaf2e938d
4 N2ab9142ad76446c2a4d48864b37936f9
5 N2bdafb6889b04bd0811fde149923686f
6 N2ff2b23d1a6a48d59b7f906504483b8c
7 N3ec85e713e20435fbeabebe751c5f631
8 N3fd666e197114109af1685749fa39a5a
9 N4d9ac5df10b84b67bffbd2370521585f
10 N566ddcc612854ca79846522853779446
11 N5a9f39c7ea2a47f686864c3cd340db40
12 N63aaaefb05aa4525a94a5adf5ba341f0
13 N77cde5feef124fa592d49e309b913a32
14 N78065f68ad5242d38a7d11544abd1159
15 N8db88f74b3d74a95a05095492431b32e
16 N8eaf8cda86be44869b9c4c2922eca720
17 N9caf03158d6f418e8ef29033da65f9a0
18 N9f13fb34b307476db0d1b45c22a9c237
19 Na3c232b9c8954e38b4fb9ea5f6046920
20 Na4264b7eb652466ba749c67e4743a38d
21 Na7390e4caa7f4d028a56bab94db80905
22 Nae63316354374a08b1fd3cf7473cfc27
23 Nb91f75662af442fdae471a1d199399a6
24 Nbfd86a58b3b8445c936f99bb1acaa3b2
25 Nc62adbd2ccb14616904703a5656be576
26 Nd69f33e58a4d479b9054db501fa03296
27 Nd6d6b3bed0c34039a991dbbd00e11f9c
28 Ndc6036bf79e64cd78530ee4717cfbb00
29 Ne7f170935b34452d93c0382709f145e2
30 Nf4dc4f8953f04407a7aff49cfa5159b2
31 Nf54117c3b1f04b1b8c3e1035185548a7
32 Nf7f4d35600f74ca394a18684b4abafe1
33 Nfd694e2fa5cd47cd8763e034f896b555
34 anzsrc-for:11
35 anzsrc-for:1112
36 schema:author N0dfc7302f8b9420e9d7dbcaf64243756
37 schema:citation sg:pub.10.1007/s11010-013-1599-5
38 sg:pub.10.1038/ng0501-29
39 sg:pub.10.1038/nri2093
40 sg:pub.10.1038/sj.onc.1205726
41 sg:pub.10.1038/sj.onc.1207787
42 sg:pub.10.1038/sj.onc.1208788
43 schema:datePublished 2016-07-28
44 schema:datePublishedReg 2016-07-28
45 schema:description Hepatocellular carcinoma (HCC) is a common cause of cancer-related death worldwide, and its incidence continues to increase. However, the mechanism underlying the development and progression of HCC remains unknown. The suppressor of cytokine signaling 2 (SOCS2) is a member of the SOCS family and influences the carcinogenesis of multiple types of tumors, but the biological roles of SOCS2 in HCC remain unclear. In this study, we found that SOCS2 expression was reduced in HCC tissues compared with matched noncancerous liver tissues. Moreover, decreased SOCS2 expression was significantly associated with the presence of intrahepatic metastasis and high histological grade in HCC patients. Colony formation assays and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays demonstrated that overexpression of SOCS2 or knockdown of endogenous SOCS2 did not significantly affect cell proliferation and tumorigenicity in HCC cells in vitro and in vivo. However, SOCS2 overexpression significantly inhibited the migration and invasion of HCC cells in vitro and inhibited metastasis in vivo. Consistent with these findings, the knockdown of endogenous SOCS2 enhanced migration and invasion in HCC cells in vitro. Our study demonstrated that SOCS2 inhibited human HCC metastasis, and SOCS2 might provide a new potential therapeutic strategy for treating HCC.
46 schema:genre article
47 schema:isAccessibleForFree false
48 schema:isPartOf N4001062bf0d64fac8a89eebcfd3c661c
49 Nf2a52c3ff25a4b3b8f36d5cd44754c02
50 sg:journal.1091981
51 schema:keywords HCC cells
52 HCC metastasis
53 HCC patients
54 HCC tissues
55 SOCS family
56 SOCS2
57 SOCS2 expression
58 SOCS2 overexpression
59 assays
60 biological role
61 bromide assay
62 cancer-related death
63 carcinogenesis
64 carcinoma
65 cause
66 cell proliferation
67 cells
68 colony formation assays
69 common cause
70 cytokines
71 death
72 development
73 dimethylthiazol-2
74 diphenyltetrazolium bromide assay
75 expression
76 family
77 findings
78 formation assays
79 grade
80 hepatocellular carcinoma
81 high histological grade
82 histological grade
83 human HCC metastasis
84 incidence
85 inhibited metastasis
86 intrahepatic metastasis
87 invasion
88 knockdown
89 liver tissue
90 mechanism
91 members
92 metastasis
93 migration
94 multiple types
95 new potential therapeutic strategy
96 noncancerous liver tissues
97 overexpression
98 overexpression of SOCS2
99 patients
100 potential therapeutic strategy
101 presence
102 progression
103 progression of HCC
104 proliferation
105 role
106 strategies
107 study
108 suppressor
109 suppressor of cytokine
110 therapeutic strategies
111 tissue
112 tumor metastasis
113 tumorigenicity
114 tumors
115 types
116 vitro
117 vivo
118 schema:name The suppressor of cytokine signaling 2 (SOCS2) inhibits tumor metastasis in hepatocellular carcinoma
119 schema:pagination 13521-13531
120 schema:productId N1ad9dcb3b49149868404147560b60d7d
121 Na3d2c57a706b402bad23f261bd5760f5
122 Nb45194c9a21044858785ad70f802772f
123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048756165
124 https://doi.org/10.1007/s13277-016-5215-7
125 schema:sdDatePublished 2022-10-01T06:42
126 schema:sdLicense https://scigraph.springernature.com/explorer/license/
127 schema:sdPublisher N29eba494f8e04761b2b92c426862c6af
128 schema:url https://doi.org/10.1007/s13277-016-5215-7
129 sgo:license sg:explorer/license/
130 sgo:sdDataset articles
131 rdf:type schema:ScholarlyArticle
132 N02201ad513654aa79d321d62edfaa536 rdf:first sg:person.01134435204.50
133 rdf:rest Ncfa82a0ef8d046dba3aea17477fe51f8
134 N030ac7f629d14b1bad3aa49ad8dc28a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Blotting, Western
136 rdf:type schema:DefinedTerm
137 N0dfc7302f8b9420e9d7dbcaf64243756 rdf:first sg:person.0705637021.06
138 rdf:rest N3e17b66deef04781913d6b882b6eed21
139 N1ad9dcb3b49149868404147560b60d7d schema:name doi
140 schema:value 10.1007/s13277-016-5215-7
141 rdf:type schema:PropertyValue
142 N2432b2513b96411eaca72cc4e2daac25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Carcinoma, Hepatocellular
144 rdf:type schema:DefinedTerm
145 N265eb4e45ad749d68dd356faaf2e938d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Neoplasm Invasiveness
147 rdf:type schema:DefinedTerm
148 N296b23015e934205adbf2edfdb85352d rdf:first sg:person.0657720126.04
149 rdf:rest N02201ad513654aa79d321d62edfaa536
150 N29eba494f8e04761b2b92c426862c6af schema:name Springer Nature - SN SciGraph project
151 rdf:type schema:Organization
152 N2ab9142ad76446c2a4d48864b37936f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Male
154 rdf:type schema:DefinedTerm
155 N2bdafb6889b04bd0811fde149923686f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Mice
157 rdf:type schema:DefinedTerm
158 N2ff2b23d1a6a48d59b7f906504483b8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Follow-Up Studies
160 rdf:type schema:DefinedTerm
161 N310cd9a6997646c9bb572ef192a96d4f rdf:first sg:person.01160767752.14
162 rdf:rest N6237cd4337e641c3a98e797dc45b94d8
163 N3e17b66deef04781913d6b882b6eed21 rdf:first sg:person.0753752221.46
164 rdf:rest Na4def64e6b61443384a557f399e9c2b4
165 N3ec85e713e20435fbeabebe751c5f631 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Real-Time Polymerase Chain Reaction
167 rdf:type schema:DefinedTerm
168 N3fd666e197114109af1685749fa39a5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Mice, Nude
170 rdf:type schema:DefinedTerm
171 N4001062bf0d64fac8a89eebcfd3c661c schema:issueNumber 10
172 rdf:type schema:PublicationIssue
173 N4d9ac5df10b84b67bffbd2370521585f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Animals
175 rdf:type schema:DefinedTerm
176 N566ddcc612854ca79846522853779446 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Cell Proliferation
178 rdf:type schema:DefinedTerm
179 N5a9f39c7ea2a47f686864c3cd340db40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Survival Rate
181 rdf:type schema:DefinedTerm
182 N6237cd4337e641c3a98e797dc45b94d8 rdf:first sg:person.01333521256.36
183 rdf:rest N67daeb75630a45fca14772baa3ec37fb
184 N63aaaefb05aa4525a94a5adf5ba341f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Aged
186 rdf:type schema:DefinedTerm
187 N67daeb75630a45fca14772baa3ec37fb rdf:first sg:person.013162461177.58
188 rdf:rest N296b23015e934205adbf2edfdb85352d
189 N77cde5feef124fa592d49e309b913a32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Reverse Transcriptase Polymerase Chain Reaction
191 rdf:type schema:DefinedTerm
192 N78065f68ad5242d38a7d11544abd1159 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Aged, 80 and over
194 rdf:type schema:DefinedTerm
195 N8db88f74b3d74a95a05095492431b32e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Xenograft Model Antitumor Assays
197 rdf:type schema:DefinedTerm
198 N8eaf8cda86be44869b9c4c2922eca720 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Immunoenzyme Techniques
200 rdf:type schema:DefinedTerm
201 N9caf03158d6f418e8ef29033da65f9a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Middle Aged
203 rdf:type schema:DefinedTerm
204 N9d4251831c3143a59d2501b430705513 rdf:first sg:person.0637523621.42
205 rdf:rest Nc53577c3784544f9a53a730d538b02d6
206 N9f13fb34b307476db0d1b45c22a9c237 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Adult
208 rdf:type schema:DefinedTerm
209 Na3c232b9c8954e38b4fb9ea5f6046920 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name RNA, Messenger
211 rdf:type schema:DefinedTerm
212 Na3d2c57a706b402bad23f261bd5760f5 schema:name pubmed_id
213 schema:value 27465557
214 rdf:type schema:PropertyValue
215 Na4264b7eb652466ba749c67e4743a38d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Prognosis
217 rdf:type schema:DefinedTerm
218 Na4def64e6b61443384a557f399e9c2b4 rdf:first sg:person.012442231175.37
219 rdf:rest N9d4251831c3143a59d2501b430705513
220 Na64228bf17a64275a650cc7d978dee92 rdf:first sg:person.0625153671.44
221 rdf:rest rdf:nil
222 Na7390e4caa7f4d028a56bab94db80905 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Neoplasm Grading
224 rdf:type schema:DefinedTerm
225 Nae63316354374a08b1fd3cf7473cfc27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Female
227 rdf:type schema:DefinedTerm
228 Nb45194c9a21044858785ad70f802772f schema:name dimensions_id
229 schema:value pub.1048756165
230 rdf:type schema:PropertyValue
231 Nb91f75662af442fdae471a1d199399a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
232 schema:name Lymphatic Metastasis
233 rdf:type schema:DefinedTerm
234 Nbfd86a58b3b8445c936f99bb1acaa3b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Cell Movement
236 rdf:type schema:DefinedTerm
237 Nc53577c3784544f9a53a730d538b02d6 rdf:first sg:person.011161037625.68
238 rdf:rest N310cd9a6997646c9bb572ef192a96d4f
239 Nc62adbd2ccb14616904703a5656be576 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Gene Expression Regulation, Neoplastic
241 rdf:type schema:DefinedTerm
242 Ncfa82a0ef8d046dba3aea17477fe51f8 rdf:first sg:person.01330252676.42
243 rdf:rest Ne050e018e22f4f35bcf399fa4458d3ed
244 Nd69f33e58a4d479b9054db501fa03296 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
245 schema:name Humans
246 rdf:type schema:DefinedTerm
247 Nd6d6b3bed0c34039a991dbbd00e11f9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
248 schema:name Suppressor of Cytokine Signaling Proteins
249 rdf:type schema:DefinedTerm
250 Ndc6036bf79e64cd78530ee4717cfbb00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
251 schema:name Young Adult
252 rdf:type schema:DefinedTerm
253 Ne050e018e22f4f35bcf399fa4458d3ed rdf:first sg:person.01275216352.01
254 rdf:rest Na64228bf17a64275a650cc7d978dee92
255 Ne7f170935b34452d93c0382709f145e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
256 schema:name Biomarkers, Tumor
257 rdf:type schema:DefinedTerm
258 Nf2a52c3ff25a4b3b8f36d5cd44754c02 schema:volumeNumber 37
259 rdf:type schema:PublicationVolume
260 Nf4dc4f8953f04407a7aff49cfa5159b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
261 schema:name Liver Neoplasms
262 rdf:type schema:DefinedTerm
263 Nf54117c3b1f04b1b8c3e1035185548a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
264 schema:name Mice, Inbred BALB C
265 rdf:type schema:DefinedTerm
266 Nf7f4d35600f74ca394a18684b4abafe1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
267 schema:name Tumor Cells, Cultured
268 rdf:type schema:DefinedTerm
269 Nfd694e2fa5cd47cd8763e034f896b555 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
270 schema:name Apoptosis
271 rdf:type schema:DefinedTerm
272 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
273 schema:name Medical and Health Sciences
274 rdf:type schema:DefinedTerm
275 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
276 schema:name Oncology and Carcinogenesis
277 rdf:type schema:DefinedTerm
278 sg:grant.7014187 http://pending.schema.org/fundedItem sg:pub.10.1007/s13277-016-5215-7
279 rdf:type schema:MonetaryGrant
280 sg:grant.8333596 http://pending.schema.org/fundedItem sg:pub.10.1007/s13277-016-5215-7
281 rdf:type schema:MonetaryGrant
282 sg:journal.1091981 schema:issn 1010-4283
283 1423-0380
284 schema:name Tumor Biology
285 schema:publisher Springer Nature
286 rdf:type schema:Periodical
287 sg:person.011161037625.68 schema:affiliation grid-institutes:grid.11841.3d
288 schema:familyName Wang
289 schema:givenName Xin
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011161037625.68
291 rdf:type schema:Person
292 sg:person.01134435204.50 schema:affiliation grid-institutes:None
293 schema:familyName Cui
294 schema:givenName Ying
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134435204.50
296 rdf:type schema:Person
297 sg:person.01160767752.14 schema:affiliation grid-institutes:grid.415869.7
298 schema:familyName Ge
299 schema:givenName Chao
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160767752.14
301 rdf:type schema:Person
302 sg:person.012442231175.37 schema:affiliation grid-institutes:grid.415869.7
303 schema:familyName Hou
304 schema:givenName Jianjing
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012442231175.37
306 rdf:type schema:Person
307 sg:person.01275216352.01 schema:affiliation grid-institutes:grid.415869.7
308 schema:familyName Li
309 schema:givenName Jinjun
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275216352.01
311 rdf:type schema:Person
312 sg:person.013162461177.58 schema:affiliation grid-institutes:None
313 schema:familyName Chen
314 schema:givenName Taoyang
315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013162461177.58
316 rdf:type schema:Person
317 sg:person.01330252676.42 schema:affiliation grid-institutes:grid.415869.7
318 schema:familyName Yao
319 schema:givenName Ming
320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330252676.42
321 rdf:type schema:Person
322 sg:person.01333521256.36 schema:affiliation grid-institutes:grid.415869.7
323 schema:familyName Zhao
324 schema:givenName Fangyu
325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333521256.36
326 rdf:type schema:Person
327 sg:person.0625153671.44 schema:affiliation grid-institutes:grid.415869.7
328 schema:familyName Li
329 schema:givenName Hong
330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625153671.44
331 rdf:type schema:Person
332 sg:person.0637523621.42 schema:affiliation grid-institutes:grid.415869.7
333 schema:familyName Fang
334 schema:givenName Tao
335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637523621.42
336 rdf:type schema:Person
337 sg:person.0657720126.04 schema:affiliation grid-institutes:grid.13402.34
338 schema:familyName Xie
339 schema:givenName Haiyang
340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657720126.04
341 rdf:type schema:Person
342 sg:person.0705637021.06 schema:affiliation grid-institutes:grid.415869.7
343 schema:familyName Cui
344 schema:givenName Meiling
345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705637021.06
346 rdf:type schema:Person
347 sg:person.0753752221.46 schema:affiliation grid-institutes:grid.11841.3d
348 schema:familyName Sun
349 schema:givenName Ji
350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753752221.46
351 rdf:type schema:Person
352 sg:pub.10.1007/s11010-013-1599-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024502994
353 https://doi.org/10.1007/s11010-013-1599-5
354 rdf:type schema:CreativeWork
355 sg:pub.10.1038/ng0501-29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003632653
356 https://doi.org/10.1038/ng0501-29
357 rdf:type schema:CreativeWork
358 sg:pub.10.1038/nri2093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010853272
359 https://doi.org/10.1038/nri2093
360 rdf:type schema:CreativeWork
361 sg:pub.10.1038/sj.onc.1205726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033591106
362 https://doi.org/10.1038/sj.onc.1205726
363 rdf:type schema:CreativeWork
364 sg:pub.10.1038/sj.onc.1207787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040948254
365 https://doi.org/10.1038/sj.onc.1207787
366 rdf:type schema:CreativeWork
367 sg:pub.10.1038/sj.onc.1208788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041084218
368 https://doi.org/10.1038/sj.onc.1208788
369 rdf:type schema:CreativeWork
370 grid-institutes:None schema:alternateName Cancer Institute of Guangxi, 530027, Nanning, China
371 Qi Dong Liver Cancer Institute, 226200, Qi Dong, China
372 schema:name Cancer Institute of Guangxi, 530027, Nanning, China
373 Qi Dong Liver Cancer Institute, 226200, Qi Dong, China
374 rdf:type schema:Organization
375 grid-institutes:grid.11841.3d schema:alternateName Shanghai Medical College, Fudan University, 200032, Shanghai, China
376 schema:name Shanghai Medical College, Fudan University, 200032, Shanghai, China
377 rdf:type schema:Organization
378 grid-institutes:grid.13402.34 schema:alternateName Department of General Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, 310003, Hangzhou, China
379 schema:name Department of General Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, 310003, Hangzhou, China
380 rdf:type schema:Organization
381 grid-institutes:grid.415869.7 schema:alternateName State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China
382 schema:name State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China
383 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...