IGF-binding protein 2 is a candidate target of therapeutic potential in cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-02

AUTHORS

Xiaofeng Yao, Shanshan Sun, Xuan Zhou, Wenyu Guo, Lun Zhang

ABSTRACT

Insulin-like growth factor (IGF)-binding protein 2(IGFBP2), a key member of IGF family, has been reported as a notable oncogene in most human epithelium cancers. Increasing evidences suggested that IGFBP2 might be a candidate target of therapuetic potential by regulating key cancer metastasis and invasion-associated signaling networks, but there is still confusion about the mechanism on how IGFBP2 takes part in these processes. In this review, we summarized the current points of view that IGFBP2 functions in signaling pathways during tumorigenesis and tumor progression and discussed its potential clinical applications as a therapeutic target. More... »

PAGES

1451-1459

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13277-015-4561-1

DOI

http://dx.doi.org/10.1007/s13277-015-4561-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002031398

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26662106


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