Identification of phosphatidylcholine and lysophosphatidylcholine as novel biomarkers for cervical cancers in a prospective cohort study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-11-13

AUTHORS

Ming-zhu Yin, Shu Tan, Xia Li, Yan Hou, Guosheng Cao, Kang Li, Junping Kou, Ge Lou

ABSTRACT

Metabolites are the end products of cellular regulatory processes. Squamous cervical cancer (SCC) can alter the level of certain small molecular metabolite in plasma through modulating gene expression. In this study, we identified two metabolites, phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), which are significantly down- and upregulated in plasma of SCC as compared to uterine fibroid (UF) patients via ultra-performance liquid chromatographic-mass spectrometry (UPLC-MS). In external prospective cohort, our assay has a sensitivity of 93.2 %, a specificity of 91.3 %, and an area under the receiver operating characteristic (ROC) curve (AUC) of 0.972. The level of LPC is significantly higher in SCC than in UF patients. An opposite result was observed in PC level. Our findings suggest that the PC and lysoPC could be used as novel biomarkers to facilitate SCC diagnosis. More... »

PAGES

5485-5492

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13277-015-4164-x

DOI

http://dx.doi.org/10.1007/s13277-015-4164-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031317001

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26566624


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