Prognostic impact of cytological fluid tumor markers in non-small cell lung cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-10-02

AUTHORS

Arthur Cho, Jin Hur, Yoo Jin Hong, Hye-Jeong Lee, Young Jin Kim, Sae Rom Hong, Young Joo Suh, Dong Jin Im, Yun Jung Kim, Jae Seok Lee, Hyo Sup Shim, Byoung Wook Choi

ABSTRACT

The serum tumor markers CYFRA 21–1, carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCCA) are useful in diagnosis and prognosis of non-small cell lung cancer (NSCLC). Cytologic tumor markers obtained during needle aspiration biopsies (NAB) of lung lesions are useful for NSCLC diagnosis. This study investigated the incremental prognostic value of cytologic tumor markers compared to serum tumor markers. This prospective study included 253 patients diagnosed with NSCLC by NAB with cytologic tumor marker analysis. Levels of cytologic CYFRA 21–1, CEA, SCCA, and their serum counterparts were followed up for survival analysis. Optimal cutoff values for each tumor marker were obtained for overall survival (OS) and progression-free survival (PFS) analyses. All patients were followed up for a median of 22.8 months. Using cutoff values of 0.44 ng/ml for C-SCCA, 2.0 ng/ml for S-SCCA, and 3.3 ng/ml for S-CYFRA, a multivariate analysis revealed that high S-SCCA (hazard ratio, HR, 1.84) and high C-SCCA (HR, 1.63) were independent predictive factors of OS. The 3-year overall survival rate was 55 vs. 80 % for high and low C-SCCA, respectively. Cytologic tumor marker level detection is easily obtainable and provides prognostic information for NSCLC. Cytologic tumor markers provide comparable prognostic information relative to serum tumor markers, with C-SCCA acting as a strong prognostic factor of overall survival and PFS. More... »

PAGES

3205-3213

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13277-015-4034-6

DOI

http://dx.doi.org/10.1007/s13277-015-4034-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000045731

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26432331


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31 schema:description The serum tumor markers CYFRA 21–1, carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCCA) are useful in diagnosis and prognosis of non-small cell lung cancer (NSCLC). Cytologic tumor markers obtained during needle aspiration biopsies (NAB) of lung lesions are useful for NSCLC diagnosis. This study investigated the incremental prognostic value of cytologic tumor markers compared to serum tumor markers. This prospective study included 253 patients diagnosed with NSCLC by NAB with cytologic tumor marker analysis. Levels of cytologic CYFRA 21–1, CEA, SCCA, and their serum counterparts were followed up for survival analysis. Optimal cutoff values for each tumor marker were obtained for overall survival (OS) and progression-free survival (PFS) analyses. All patients were followed up for a median of 22.8 months. Using cutoff values of 0.44 ng/ml for C-SCCA, 2.0 ng/ml for S-SCCA, and 3.3 ng/ml for S-CYFRA, a multivariate analysis revealed that high S-SCCA (hazard ratio, HR, 1.84) and high C-SCCA (HR, 1.63) were independent predictive factors of OS. The 3-year overall survival rate was 55 vs. 80 % for high and low C-SCCA, respectively. Cytologic tumor marker level detection is easily obtainable and provides prognostic information for NSCLC. Cytologic tumor markers provide comparable prognostic information relative to serum tumor markers, with C-SCCA acting as a strong prognostic factor of overall survival and PFS.
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38 NSCLC diagnosis
39 PFS
40 acting
41 analysis
42 antigen
43 aspiration biopsy
44 biopsy
45 cancer
46 carcinoembryonic antigen
47 carcinoma antigen
48 cell lung cancer
49 comparable prognostic information
50 counterparts
51 cutoff value
52 detection
53 diagnosis
54 factors
55 fluid tumor markers
56 impact
57 incremental prognostic value
58 independent predictive factors
59 information
60 lesions
61 level detection
62 levels
63 lung cancer
64 lung lesions
65 marker analysis
66 markers
67 median
68 months
69 multivariate analysis
70 needle aspiration biopsy
71 non-small cell lung cancer
72 optimal cutoff value
73 overall survival
74 overall survival rate
75 patients
76 predictive factors
77 prognosis
78 prognostic factors
79 prognostic impact
80 prognostic information
81 prognostic value
82 progression-free survival analysis
83 prospective study
84 rate
85 serum counterpart
86 serum tumor markers
87 serum tumor markers CYFRA 21
88 squamous cell carcinoma antigen
89 strong prognostic factor
90 study
91 survival
92 survival analysis
93 survival rate
94 tumor marker analysis
95 tumor markers
96 tumor markers CYFRA 21
97 values
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