Strong expression of polypeptide N-acetylgalactosaminyltransferase 3 independently predicts shortened disease-free survival in patients with early stage oral squamous cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-08-22

AUTHORS

Yoshikazu Harada, Hiroto Izumi, Hirotsugu Noguchi, Akihiro Kuma, Yuichiro Kawatsu, Tomoko Kimura, Shohei Kitada, Hidetaka Uramoto, Ke-Yong Wang, Yasuyuki Sasaguri, Hiroshi Hijioka, Akihiko Miyawaki, Ryoichi Oya, Toshiyuki Nakayama, Kimitoshi Kohno, Sohsuke Yamada

ABSTRACT

The polypeptide N-acetylgalactosaminyltransferase (GalNAc-Ts) family of enzymes regulates the critical initial steps of mucin-type O-glycosylation. Among GalNAc-Ts that may significantly influence cancer biology, thus affecting cell differentiation, adhesion, invasion, and/or metastasis, GalNAc-T3 exhibits a high expression in several human cancers, closely associated with tumor progression and a poor prognosis. However, the expression pattern of GalNAc-T3 in oral squamous cell carcinoma (OSCC) remains obscure. Since postoperative recurrence of even early stage OSCC (ESOSCC) occurs at an early phase, significantly affecting their clinical course and worse outcome, the identification of clinically significant accurate biomarkers is needed. Therefore, we investigated the correlation between the immunohistochemical GalNAc-T3 expression and various clinicopathological characteristics and recurrence using 110 paraffin-embedded tumor samples obtained from patients with surgically resected ESOSCC (T1-2N0). Recurrence was recognized in 37 of 110 (33.6 %) patients. The GalNAc-T3 expression was considered to be strongly positive when 20 % or more of the cancer cells showed positive cytoplasmic staining. Consequently, a strong expression of GalNAc-T3 was observed in 40 patients (36.4 %), showing a close relationship to poor differentiation, the presence of lymphatic and vascular invasion, and recurrence. Univariate and multivariate analyses further demonstrated that the patients with a strong GalNAc-T3+ status had markedly lower disease-free survival (DFS) rates, especially within the first 2 years postoperatively. Therefore, GalNAc-T3 might play a role in the pathogenesis of ESOSCC recurrence, and its immunohistochemical detection potentially predicts a shorter DFS and may be a useful parameter for providing clinical management against ESOSCC in the early postoperative phase. More... »

PAGES

1357-1368

References to SciGraph publications

  • 2002-09-23. N-acetylgalactosaminyl transferase-3 is a potential new marker for non-small cell lung cancers in BRITISH JOURNAL OF CANCER
  • 2014-07-26. The combination of a nuclear HMGB1-positive and HMGB2-negative expression is potentially associated with a shortened survival in patients with pancreatic ductal adenocarcinoma in TUMOR BIOLOGY
  • 2013-05-17. Predictors of Locoregional Recurrence in T1-2N0 Tongue Cancer Patients in PATHOLOGY & ONCOLOGY RESEARCH
  • 2014-04-15. The combination of strong expression of ZNF143 and high MIB-1 labelling index independently predicts shorter disease-specific survival in lung adenocarcinoma in BRITISH JOURNAL OF CANCER
  • 2004-01. Mucins in cancer: protection and control of the cell surface in NATURE REVIEWS CANCER
  • 2004-01-20. Low expression of polypeptide GalNAc N-acetylgalactosaminyl transferase-3 in lung adenocarcinoma: impact on poor prognosis and early recurrence in BRITISH JOURNAL OF CANCER
  • 2013-06-25. Polypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas in BRITISH JOURNAL OF CANCER
  • 2012-12-03. Investigation of the freely available easy-to-use software ‘EZR' for medical statistics in BONE MARROW TRANSPLANTATION
  • 2011-05-17. Polypeptide N-acetylgalactosaminyltransferase 6 expression in pancreatic cancer is an independent prognostic factor indicating better overall survival in BRITISH JOURNAL OF CANCER
  • 2014-03-25. Update of molecular pathobiology in oral cancer: a review in INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
  • 2007-02-09. Expression of GalNAc-T3 and its relationships with clinicopathological factors in 61 extrahepatic bile duct carcinomas analyzed using stepwise sections—Special reference to its association with lymph node metastases— in MODERN PATHOLOGY
  • Journal

    TITLE

    Tumor Biology

    ISSUE

    1

    VOLUME

    37

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13277-015-3928-7

    DOI

    http://dx.doi.org/10.1007/s13277-015-3928-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049331931

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26296622


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Squamous Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Adhesion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytoplasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Progression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease-Free Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glycosylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunohistochemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microscopy, Fluorescence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mouth Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "N-Acetylgalactosaminyltransferases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Invasiveness", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Recurrence, Local", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Dentistry and Oral Surgery, University Hospital of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan", 
              "id": "http://www.grid.ac/institutes/grid.271052.3", 
              "name": [
                "Department of Pathology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan", 
                "Department of Dentistry and Oral Surgery, University Hospital of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Harada", 
            "givenName": "Yoshikazu", 
            "id": "sg:person.01111013734.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111013734.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Occupational Pneumology, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan", 
              "id": "http://www.grid.ac/institutes/grid.271052.3", 
              "name": [
                "Department of Occupational Pneumology, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Izumi", 
            "givenName": "Hiroto", 
            "id": "sg:person.01007122017.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007122017.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan", 
              "id": "http://www.grid.ac/institutes/grid.271052.3", 
              "name": [
                "Department of Pathology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Noguchi", 
            "givenName": "Hirotsugu", 
            "id": "sg:person.01340765141.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340765141.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Second Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan", 
              "id": "http://www.grid.ac/institutes/grid.271052.3", 
              "name": [
                "Department of Second Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kuma", 
            "givenName": "Akihiro", 
            "id": "sg:person.0710045670.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710045670.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan", 
              "id": "http://www.grid.ac/institutes/grid.271052.3", 
              "name": [
                "Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kawatsu", 
            "givenName": "Yuichiro", 
            "id": "sg:person.01214622330.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214622330.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan", 
              "id": "http://www.grid.ac/institutes/grid.271052.3", 
              "name": [
                "Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kimura", 
            "givenName": "Tomoko", 
            "id": "sg:person.0721673230.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721673230.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Urology, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan", 
              "id": "http://www.grid.ac/institutes/grid.271052.3", 
              "name": [
                "Department of Pathology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan", 
                "Department of Urology, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kitada", 
            "givenName": "Shohei", 
            "id": "sg:person.01053346165.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053346165.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan", 
              "id": "http://www.grid.ac/institutes/grid.271052.3", 
              "name": [
                "Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uramoto", 
            "givenName": "Hidetaka", 
            "id": "sg:person.01226655274.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226655274.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shared-Use Research Center, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan", 
              "id": "http://www.grid.ac/institutes/grid.271052.3", 
              "name": [
                "Department of Pathology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan", 
                "Shared-Use Research Center, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Ke-Yong", 
            "id": "sg:person.0616131554.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616131554.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Pathology, Fukuoka Wajiro Hospital, Fukuoka, 811-0213 Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Pathology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan", 
                "Laboratory of Pathology, Fukuoka Wajiro Hospital, Fukuoka, 811-0213 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sasaguri", 
            "givenName": "Yasuyuki", 
            "id": "sg:person.01304023165.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304023165.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshima 890-8520 Japan", 
              "id": "http://www.grid.ac/institutes/grid.258333.c", 
              "name": [
                "Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshima 890-8520 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hijioka", 
            "givenName": "Hiroshi", 
            "id": "sg:person.0626717613.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626717613.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dentistry and Oral Surgery, University Hospital of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan", 
              "id": "http://www.grid.ac/institutes/grid.271052.3", 
              "name": [
                "Department of Dentistry and Oral Surgery, University Hospital of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miyawaki", 
            "givenName": "Akihiko", 
            "id": "sg:person.07562253421.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07562253421.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dentistry and Oral Surgery, University Hospital of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan", 
              "id": "http://www.grid.ac/institutes/grid.271052.3", 
              "name": [
                "Department of Dentistry and Oral Surgery, University Hospital of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oya", 
            "givenName": "Ryoichi", 
            "id": "sg:person.01150606001.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150606001.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan", 
              "id": "http://www.grid.ac/institutes/grid.271052.3", 
              "name": [
                "Department of Pathology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakayama", 
            "givenName": "Toshiyuki", 
            "id": "sg:person.012204001432.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012204001432.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Asahi-Matsumoto Hospital, Kitakyushu, 800-0242 Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Asahi-Matsumoto Hospital, Kitakyushu, 800-0242 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kohno", 
            "givenName": "Kimitoshi", 
            "id": "sg:person.0745037146.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745037146.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Molecular Biosciences, University of Graz, Graz, 8010 Austria", 
              "id": "http://www.grid.ac/institutes/grid.5110.5", 
              "name": [
                "Department of Pathology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan", 
                "Institute of Pathology, Medical University of Graz, Graz, 8010 Austria", 
                "Institute of Molecular Biosciences, University of Graz, Graz, 8010 Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamada", 
            "givenName": "Sohsuke", 
            "id": "sg:person.01103750361.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103750361.46"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/bjc.2014.202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048746583", 
              "https://doi.org/10.1038/bjc.2014.202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2011.166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002235856", 
              "https://doi.org/10.1038/bjc.2011.166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2012.244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028358194", 
              "https://doi.org/10.1038/bmt.2012.244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052855187", 
              "https://doi.org/10.1038/nrc1251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10147-014-0684-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023563594", 
              "https://doi.org/10.1007/s10147-014-0684-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6601531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028884561", 
              "https://doi.org/10.1038/sj.bjc.6601531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6600536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048736947", 
              "https://doi.org/10.1038/sj.bjc.6600536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3800700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019137807", 
              "https://doi.org/10.1038/modpathol.3800700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12253-013-9646-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014157564", 
              "https://doi.org/10.1007/s12253-013-9646-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13277-014-2328-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041613308", 
              "https://doi.org/10.1007/s13277-014-2328-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014800721", 
              "https://doi.org/10.1038/bjc.2013.331"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-08-22", 
        "datePublishedReg": "2015-08-22", 
        "description": "The polypeptide N-acetylgalactosaminyltransferase (GalNAc-Ts) family of enzymes regulates the critical initial steps of mucin-type O-glycosylation. Among GalNAc-Ts that may significantly influence cancer biology, thus affecting cell differentiation, adhesion, invasion, and/or metastasis, GalNAc-T3 exhibits a high expression in several human cancers, closely associated with tumor progression and a poor prognosis. However, the expression pattern of GalNAc-T3 in oral squamous cell carcinoma (OSCC) remains obscure. Since postoperative recurrence of even early stage OSCC (ESOSCC) occurs at an early phase, significantly affecting their clinical course and worse outcome, the identification of clinically significant accurate biomarkers is needed. Therefore, we investigated the correlation between the immunohistochemical GalNAc-T3 expression and various clinicopathological characteristics and recurrence using 110 paraffin-embedded tumor samples obtained from patients with surgically resected ESOSCC (T1-2N0). Recurrence was recognized in 37 of 110 (33.6\u00a0%) patients. The GalNAc-T3 expression was considered to be strongly positive when 20\u00a0% or more of the cancer cells showed positive cytoplasmic staining. Consequently, a strong expression of GalNAc-T3 was observed in 40 patients (36.4\u00a0%), showing a close relationship to poor differentiation, the presence of lymphatic and vascular invasion, and recurrence. Univariate and multivariate analyses further demonstrated that the patients with a strong GalNAc-T3+ status had markedly lower disease-free survival (DFS) rates, especially within the first 2\u00a0years postoperatively. Therefore, GalNAc-T3 might play a role in the pathogenesis of ESOSCC recurrence, and its immunohistochemical detection potentially predicts a shorter DFS and may be a useful parameter for providing clinical management against ESOSCC in the early postoperative phase. ", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s13277-015-3928-7", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6097532", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1091981", 
            "issn": [
              "1010-4283", 
              "1423-0380"
            ], 
            "name": "Tumor Biology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "37"
          }
        ], 
        "keywords": [
          "oral squamous cell carcinoma", 
          "early-stage OSCC", 
          "early-stage oral squamous cell carcinoma", 
          "stage oral squamous cell carcinoma", 
          "squamous cell carcinoma", 
          "GalNAc-T3 expression", 
          "cell carcinoma", 
          "GalNAc-T3", 
          "lower disease-free survival rate", 
          "disease-free survival rates", 
          "paraffin-embedded tumor samples", 
          "disease-free survival", 
          "early postoperative phase", 
          "strong expression", 
          "positive cytoplasmic staining", 
          "shorter DFS", 
          "postoperative recurrence", 
          "clinical course", 
          "clinicopathological characteristics", 
          "postoperative phase", 
          "poor prognosis", 
          "vascular invasion", 
          "worse outcomes", 
          "poor differentiation", 
          "clinical management", 
          "accurate biomarkers", 
          "patients", 
          "immunohistochemical detection", 
          "recurrence", 
          "survival rate", 
          "cytoplasmic staining", 
          "tumor progression", 
          "tumor samples", 
          "high expression", 
          "cancer cells", 
          "human cancers", 
          "polypeptide N", 
          "carcinoma", 
          "acetylgalactosaminyltransferase 3", 
          "cancer biology", 
          "early phase", 
          "critical initial step", 
          "cell differentiation", 
          "useful parameter", 
          "invasion", 
          "expression", 
          "expression patterns", 
          "prognosis", 
          "metastasis", 
          "pathogenesis", 
          "cancer", 
          "DFS", 
          "progression", 
          "biomarkers", 
          "differentiation", 
          "survival", 
          "staining", 
          "outcomes", 
          "mucin-type O", 
          "acetylgalactosaminyltransferase family", 
          "status", 
          "cells", 
          "initial step", 
          "years", 
          "course", 
          "close relationship", 
          "management", 
          "role", 
          "rate", 
          "correlation", 
          "GalNAc-Ts", 
          "enzyme", 
          "presence", 
          "family", 
          "adhesion", 
          "patterns", 
          "identification", 
          "samples", 
          "biology", 
          "relationship", 
          "detection", 
          "glycosylation", 
          "analysis", 
          "characteristics", 
          "phase", 
          "parameters", 
          "step", 
          "significant accurate biomarkers", 
          "immunohistochemical GalNAc-T3 expression", 
          "strong GalNAc-T3", 
          "ESOSCC recurrence"
        ], 
        "name": "Strong expression of polypeptide N-acetylgalactosaminyltransferase 3 independently predicts shortened disease-free survival in patients with early stage oral squamous cell carcinoma", 
        "pagination": "1357-1368", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1049331931"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s13277-015-3928-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26296622"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s13277-015-3928-7", 
          "https://app.dimensions.ai/details/publication/pub.1049331931"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:36", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_655.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s13277-015-3928-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13277-015-3928-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13277-015-3928-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13277-015-3928-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13277-015-3928-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    444 TRIPLES      22 PREDICATES      156 URIs      137 LITERALS      35 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s13277-015-3928-7 schema:about N06320834d7264092b73423953ceb8e97
    2 N093a67f6bae440cb92df740c0e396f8e
    3 N129cd61ea68a4a8c851e8d2c3c8e289c
    4 N18135b167abe47be80043c5d26025e49
    5 N1f38283ddc3743bc947d0ab9a5a34a07
    6 N3b16b60354cb475ea6d0c53900d2112e
    7 N4839ac49a7d542eca5f531b74d69a766
    8 N530452495a0f430ba88553f0b6838c9f
    9 N65a4b963a5dd4ab8829a76aa8279bde1
    10 N850d19778a3247938f154c135b49fd95
    11 N855b441798a148c3aa157ccd596bbe30
    12 N86c6e38fd01841609a766be5ab7bab21
    13 N8b619e2c3ee04a5fb41010ed96b12a03
    14 N97fb6e14839440e0846c524df0b0363b
    15 Na204b849836c40bead701b690f9ac709
    16 Na225ca7efc404ddf947ecec49ed1588d
    17 Nb2529b7f02354df4922298a828573af8
    18 Nb8d91255280b455d8bad37070121ae3f
    19 Nb960320a6aa04bc98df9c6d5ac9c54dc
    20 Nca0ac6a098ef4199826df581163802bc
    21 Nd949acad98f54a299fc7a67471570348
    22 Ndf14fb5f022a4114bd7a258d2dc489cf
    23 Ne0a46469f34541ebb105feaa4921cc50
    24 Ne3fda3c13af94784a9fed667779b3f97
    25 Nebd26421a40c4842bf19cbf17e548915
    26 Nf8a6dfbff1064af9bb04c30e4053127b
    27 Nf988e2c1e8bf49109791f32820ca0a63
    28 Nff4605eaf5864439b845eae3e3533649
    29 anzsrc-for:11
    30 anzsrc-for:1112
    31 schema:author N3022cbdcb8014526ba4fceb0c57ec9c8
    32 schema:citation sg:pub.10.1007/s10147-014-0684-4
    33 sg:pub.10.1007/s12253-013-9646-9
    34 sg:pub.10.1007/s13277-014-2328-8
    35 sg:pub.10.1038/bjc.2011.166
    36 sg:pub.10.1038/bjc.2013.331
    37 sg:pub.10.1038/bjc.2014.202
    38 sg:pub.10.1038/bmt.2012.244
    39 sg:pub.10.1038/modpathol.3800700
    40 sg:pub.10.1038/nrc1251
    41 sg:pub.10.1038/sj.bjc.6600536
    42 sg:pub.10.1038/sj.bjc.6601531
    43 schema:datePublished 2015-08-22
    44 schema:datePublishedReg 2015-08-22
    45 schema:description The polypeptide N-acetylgalactosaminyltransferase (GalNAc-Ts) family of enzymes regulates the critical initial steps of mucin-type O-glycosylation. Among GalNAc-Ts that may significantly influence cancer biology, thus affecting cell differentiation, adhesion, invasion, and/or metastasis, GalNAc-T3 exhibits a high expression in several human cancers, closely associated with tumor progression and a poor prognosis. However, the expression pattern of GalNAc-T3 in oral squamous cell carcinoma (OSCC) remains obscure. Since postoperative recurrence of even early stage OSCC (ESOSCC) occurs at an early phase, significantly affecting their clinical course and worse outcome, the identification of clinically significant accurate biomarkers is needed. Therefore, we investigated the correlation between the immunohistochemical GalNAc-T3 expression and various clinicopathological characteristics and recurrence using 110 paraffin-embedded tumor samples obtained from patients with surgically resected ESOSCC (T1-2N0). Recurrence was recognized in 37 of 110 (33.6 %) patients. The GalNAc-T3 expression was considered to be strongly positive when 20 % or more of the cancer cells showed positive cytoplasmic staining. Consequently, a strong expression of GalNAc-T3 was observed in 40 patients (36.4 %), showing a close relationship to poor differentiation, the presence of lymphatic and vascular invasion, and recurrence. Univariate and multivariate analyses further demonstrated that the patients with a strong GalNAc-T3+ status had markedly lower disease-free survival (DFS) rates, especially within the first 2 years postoperatively. Therefore, GalNAc-T3 might play a role in the pathogenesis of ESOSCC recurrence, and its immunohistochemical detection potentially predicts a shorter DFS and may be a useful parameter for providing clinical management against ESOSCC in the early postoperative phase.
    46 schema:genre article
    47 schema:inLanguage en
    48 schema:isAccessibleForFree true
    49 schema:isPartOf N327e83d013cc48b582d4b076c1fa9959
    50 Nffa930d104ff44989efe14d637778092
    51 sg:journal.1091981
    52 schema:keywords DFS
    53 ESOSCC recurrence
    54 GalNAc-T3
    55 GalNAc-T3 expression
    56 GalNAc-Ts
    57 accurate biomarkers
    58 acetylgalactosaminyltransferase 3
    59 acetylgalactosaminyltransferase family
    60 adhesion
    61 analysis
    62 biology
    63 biomarkers
    64 cancer
    65 cancer biology
    66 cancer cells
    67 carcinoma
    68 cell carcinoma
    69 cell differentiation
    70 cells
    71 characteristics
    72 clinical course
    73 clinical management
    74 clinicopathological characteristics
    75 close relationship
    76 correlation
    77 course
    78 critical initial step
    79 cytoplasmic staining
    80 detection
    81 differentiation
    82 disease-free survival
    83 disease-free survival rates
    84 early phase
    85 early postoperative phase
    86 early-stage OSCC
    87 early-stage oral squamous cell carcinoma
    88 enzyme
    89 expression
    90 expression patterns
    91 family
    92 glycosylation
    93 high expression
    94 human cancers
    95 identification
    96 immunohistochemical GalNAc-T3 expression
    97 immunohistochemical detection
    98 initial step
    99 invasion
    100 lower disease-free survival rate
    101 management
    102 metastasis
    103 mucin-type O
    104 oral squamous cell carcinoma
    105 outcomes
    106 paraffin-embedded tumor samples
    107 parameters
    108 pathogenesis
    109 patients
    110 patterns
    111 phase
    112 polypeptide N
    113 poor differentiation
    114 poor prognosis
    115 positive cytoplasmic staining
    116 postoperative phase
    117 postoperative recurrence
    118 presence
    119 prognosis
    120 progression
    121 rate
    122 recurrence
    123 relationship
    124 role
    125 samples
    126 shorter DFS
    127 significant accurate biomarkers
    128 squamous cell carcinoma
    129 stage oral squamous cell carcinoma
    130 staining
    131 status
    132 step
    133 strong GalNAc-T3
    134 strong expression
    135 survival
    136 survival rate
    137 tumor progression
    138 tumor samples
    139 useful parameter
    140 vascular invasion
    141 worse outcomes
    142 years
    143 schema:name Strong expression of polypeptide N-acetylgalactosaminyltransferase 3 independently predicts shortened disease-free survival in patients with early stage oral squamous cell carcinoma
    144 schema:pagination 1357-1368
    145 schema:productId N159228bba8f947deb6de19ab05869975
    146 N6d972258e31d47ccb68c82d9ecf55151
    147 N7e322dc418dd493fb8f938a678b977d4
    148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049331931
    149 https://doi.org/10.1007/s13277-015-3928-7
    150 schema:sdDatePublished 2022-01-01T18:36
    151 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    152 schema:sdPublisher Nd1a7acbea50e4c5bb4775f43db1a684d
    153 schema:url https://doi.org/10.1007/s13277-015-3928-7
    154 sgo:license sg:explorer/license/
    155 sgo:sdDataset articles
    156 rdf:type schema:ScholarlyArticle
    157 N06320834d7264092b73423953ceb8e97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Glycosylation
    159 rdf:type schema:DefinedTerm
    160 N093a67f6bae440cb92df740c0e396f8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name N-Acetylgalactosaminyltransferases
    162 rdf:type schema:DefinedTerm
    163 N129cd61ea68a4a8c851e8d2c3c8e289c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Prognosis
    165 rdf:type schema:DefinedTerm
    166 N1563ee1ce7bb4e6f9facc1012fbce673 rdf:first sg:person.012204001432.88
    167 rdf:rest Nc2ac2e146c144f50b9e8b72c6c68531b
    168 N159228bba8f947deb6de19ab05869975 schema:name doi
    169 schema:value 10.1007/s13277-015-3928-7
    170 rdf:type schema:PropertyValue
    171 N18135b167abe47be80043c5d26025e49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Adult
    173 rdf:type schema:DefinedTerm
    174 N1f38283ddc3743bc947d0ab9a5a34a07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Biomarkers, Tumor
    176 rdf:type schema:DefinedTerm
    177 N3022cbdcb8014526ba4fceb0c57ec9c8 rdf:first sg:person.01111013734.00
    178 rdf:rest Nb22e17b5b254440f918869c3c7ce5b54
    179 N327e83d013cc48b582d4b076c1fa9959 schema:volumeNumber 37
    180 rdf:type schema:PublicationVolume
    181 N38b5abacddf745e89dd15cbc70ac3484 rdf:first sg:person.0710045670.41
    182 rdf:rest N94836e43a23c43789b8a92ec5e132307
    183 N3b16b60354cb475ea6d0c53900d2112e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Gene Expression Regulation, Neoplastic
    185 rdf:type schema:DefinedTerm
    186 N4839ac49a7d542eca5f531b74d69a766 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Aged, 80 and over
    188 rdf:type schema:DefinedTerm
    189 N530452495a0f430ba88553f0b6838c9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Immunohistochemistry
    191 rdf:type schema:DefinedTerm
    192 N65a4b963a5dd4ab8829a76aa8279bde1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Mouth Neoplasms
    194 rdf:type schema:DefinedTerm
    195 N6d972258e31d47ccb68c82d9ecf55151 schema:name dimensions_id
    196 schema:value pub.1049331931
    197 rdf:type schema:PropertyValue
    198 N751bc65723464fa7979ca2971d8d51ee rdf:first sg:person.01053346165.54
    199 rdf:rest N9affd62ad53445569b1c44dfdd01131a
    200 N7b7dbd2a752442729cace41df831f802 rdf:first sg:person.0616131554.41
    201 rdf:rest Nf6e5c5f730d14f88b2c5654080e813a0
    202 N7e322dc418dd493fb8f938a678b977d4 schema:name pubmed_id
    203 schema:value 26296622
    204 rdf:type schema:PropertyValue
    205 N850d19778a3247938f154c135b49fd95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Gene Expression Profiling
    207 rdf:type schema:DefinedTerm
    208 N855b441798a148c3aa157ccd596bbe30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Neoplasm Proteins
    210 rdf:type schema:DefinedTerm
    211 N86c6e38fd01841609a766be5ab7bab21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Female
    213 rdf:type schema:DefinedTerm
    214 N8b619e2c3ee04a5fb41010ed96b12a03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Young Adult
    216 rdf:type schema:DefinedTerm
    217 N8beaef3416044005a32804525cce3c53 rdf:first sg:person.0721673230.45
    218 rdf:rest N751bc65723464fa7979ca2971d8d51ee
    219 N94836e43a23c43789b8a92ec5e132307 rdf:first sg:person.01214622330.01
    220 rdf:rest N8beaef3416044005a32804525cce3c53
    221 N97fb6e14839440e0846c524df0b0363b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name Neoplasm Invasiveness
    223 rdf:type schema:DefinedTerm
    224 N9affd62ad53445569b1c44dfdd01131a rdf:first sg:person.01226655274.18
    225 rdf:rest N7b7dbd2a752442729cace41df831f802
    226 Na204b849836c40bead701b690f9ac709 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    227 schema:name Cell Adhesion
    228 rdf:type schema:DefinedTerm
    229 Na225ca7efc404ddf947ecec49ed1588d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    230 schema:name Cell Line, Tumor
    231 rdf:type schema:DefinedTerm
    232 Na4356496d4dc4a27a83dae0574a0166e rdf:first sg:person.01103750361.46
    233 rdf:rest rdf:nil
    234 Nb22e17b5b254440f918869c3c7ce5b54 rdf:first sg:person.01007122017.64
    235 rdf:rest Nc6cd2dd438c146448c025855f06d511c
    236 Nb2529b7f02354df4922298a828573af8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    237 schema:name Carcinoma, Squamous Cell
    238 rdf:type schema:DefinedTerm
    239 Nb37454d7849b4b60936ba38c3f2586bd rdf:first sg:person.01150606001.14
    240 rdf:rest N1563ee1ce7bb4e6f9facc1012fbce673
    241 Nb651da85e3684fcfa6139bc14157dbfe rdf:first sg:person.07562253421.11
    242 rdf:rest Nb37454d7849b4b60936ba38c3f2586bd
    243 Nb8d91255280b455d8bad37070121ae3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    244 schema:name Microscopy, Fluorescence
    245 rdf:type schema:DefinedTerm
    246 Nb960320a6aa04bc98df9c6d5ac9c54dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    247 schema:name Disease-Free Survival
    248 rdf:type schema:DefinedTerm
    249 Nc2ac2e146c144f50b9e8b72c6c68531b rdf:first sg:person.0745037146.34
    250 rdf:rest Na4356496d4dc4a27a83dae0574a0166e
    251 Nc6cd2dd438c146448c025855f06d511c rdf:first sg:person.01340765141.30
    252 rdf:rest N38b5abacddf745e89dd15cbc70ac3484
    253 Nca0ac6a098ef4199826df581163802bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    254 schema:name Male
    255 rdf:type schema:DefinedTerm
    256 Ncfa8e2f37a4f45aa877f01fd88e48461 rdf:first sg:person.0626717613.79
    257 rdf:rest Nb651da85e3684fcfa6139bc14157dbfe
    258 Nd1a7acbea50e4c5bb4775f43db1a684d schema:name Springer Nature - SN SciGraph project
    259 rdf:type schema:Organization
    260 Nd949acad98f54a299fc7a67471570348 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    261 schema:name Cytoplasm
    262 rdf:type schema:DefinedTerm
    263 Ndf14fb5f022a4114bd7a258d2dc489cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    264 schema:name Neoplasm Recurrence, Local
    265 rdf:type schema:DefinedTerm
    266 Ne0a46469f34541ebb105feaa4921cc50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    267 schema:name Middle Aged
    268 rdf:type schema:DefinedTerm
    269 Ne3fda3c13af94784a9fed667779b3f97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    270 schema:name Disease Progression
    271 rdf:type schema:DefinedTerm
    272 Nebd26421a40c4842bf19cbf17e548915 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    273 schema:name Cell Differentiation
    274 rdf:type schema:DefinedTerm
    275 Nf6e5c5f730d14f88b2c5654080e813a0 rdf:first sg:person.01304023165.50
    276 rdf:rest Ncfa8e2f37a4f45aa877f01fd88e48461
    277 Nf8a6dfbff1064af9bb04c30e4053127b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    278 schema:name Humans
    279 rdf:type schema:DefinedTerm
    280 Nf988e2c1e8bf49109791f32820ca0a63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    281 schema:name Neoplasm Metastasis
    282 rdf:type schema:DefinedTerm
    283 Nff4605eaf5864439b845eae3e3533649 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    284 schema:name Aged
    285 rdf:type schema:DefinedTerm
    286 Nffa930d104ff44989efe14d637778092 schema:issueNumber 1
    287 rdf:type schema:PublicationIssue
    288 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    289 schema:name Medical and Health Sciences
    290 rdf:type schema:DefinedTerm
    291 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    292 schema:name Oncology and Carcinogenesis
    293 rdf:type schema:DefinedTerm
    294 sg:grant.6097532 http://pending.schema.org/fundedItem sg:pub.10.1007/s13277-015-3928-7
    295 rdf:type schema:MonetaryGrant
    296 sg:journal.1091981 schema:issn 1010-4283
    297 1423-0380
    298 schema:name Tumor Biology
    299 schema:publisher Springer Nature
    300 rdf:type schema:Periodical
    301 sg:person.01007122017.64 schema:affiliation grid-institutes:grid.271052.3
    302 schema:familyName Izumi
    303 schema:givenName Hiroto
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007122017.64
    305 rdf:type schema:Person
    306 sg:person.01053346165.54 schema:affiliation grid-institutes:grid.271052.3
    307 schema:familyName Kitada
    308 schema:givenName Shohei
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053346165.54
    310 rdf:type schema:Person
    311 sg:person.01103750361.46 schema:affiliation grid-institutes:grid.5110.5
    312 schema:familyName Yamada
    313 schema:givenName Sohsuke
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103750361.46
    315 rdf:type schema:Person
    316 sg:person.01111013734.00 schema:affiliation grid-institutes:grid.271052.3
    317 schema:familyName Harada
    318 schema:givenName Yoshikazu
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111013734.00
    320 rdf:type schema:Person
    321 sg:person.01150606001.14 schema:affiliation grid-institutes:grid.271052.3
    322 schema:familyName Oya
    323 schema:givenName Ryoichi
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150606001.14
    325 rdf:type schema:Person
    326 sg:person.01214622330.01 schema:affiliation grid-institutes:grid.271052.3
    327 schema:familyName Kawatsu
    328 schema:givenName Yuichiro
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214622330.01
    330 rdf:type schema:Person
    331 sg:person.012204001432.88 schema:affiliation grid-institutes:grid.271052.3
    332 schema:familyName Nakayama
    333 schema:givenName Toshiyuki
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012204001432.88
    335 rdf:type schema:Person
    336 sg:person.01226655274.18 schema:affiliation grid-institutes:grid.271052.3
    337 schema:familyName Uramoto
    338 schema:givenName Hidetaka
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226655274.18
    340 rdf:type schema:Person
    341 sg:person.01304023165.50 schema:affiliation grid-institutes:None
    342 schema:familyName Sasaguri
    343 schema:givenName Yasuyuki
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304023165.50
    345 rdf:type schema:Person
    346 sg:person.01340765141.30 schema:affiliation grid-institutes:grid.271052.3
    347 schema:familyName Noguchi
    348 schema:givenName Hirotsugu
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340765141.30
    350 rdf:type schema:Person
    351 sg:person.0616131554.41 schema:affiliation grid-institutes:grid.271052.3
    352 schema:familyName Wang
    353 schema:givenName Ke-Yong
    354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616131554.41
    355 rdf:type schema:Person
    356 sg:person.0626717613.79 schema:affiliation grid-institutes:grid.258333.c
    357 schema:familyName Hijioka
    358 schema:givenName Hiroshi
    359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626717613.79
    360 rdf:type schema:Person
    361 sg:person.0710045670.41 schema:affiliation grid-institutes:grid.271052.3
    362 schema:familyName Kuma
    363 schema:givenName Akihiro
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710045670.41
    365 rdf:type schema:Person
    366 sg:person.0721673230.45 schema:affiliation grid-institutes:grid.271052.3
    367 schema:familyName Kimura
    368 schema:givenName Tomoko
    369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721673230.45
    370 rdf:type schema:Person
    371 sg:person.0745037146.34 schema:affiliation grid-institutes:None
    372 schema:familyName Kohno
    373 schema:givenName Kimitoshi
    374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745037146.34
    375 rdf:type schema:Person
    376 sg:person.07562253421.11 schema:affiliation grid-institutes:grid.271052.3
    377 schema:familyName Miyawaki
    378 schema:givenName Akihiko
    379 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07562253421.11
    380 rdf:type schema:Person
    381 sg:pub.10.1007/s10147-014-0684-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023563594
    382 https://doi.org/10.1007/s10147-014-0684-4
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1007/s12253-013-9646-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014157564
    385 https://doi.org/10.1007/s12253-013-9646-9
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1007/s13277-014-2328-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041613308
    388 https://doi.org/10.1007/s13277-014-2328-8
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1038/bjc.2011.166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002235856
    391 https://doi.org/10.1038/bjc.2011.166
    392 rdf:type schema:CreativeWork
    393 sg:pub.10.1038/bjc.2013.331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014800721
    394 https://doi.org/10.1038/bjc.2013.331
    395 rdf:type schema:CreativeWork
    396 sg:pub.10.1038/bjc.2014.202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048746583
    397 https://doi.org/10.1038/bjc.2014.202
    398 rdf:type schema:CreativeWork
    399 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
    400 https://doi.org/10.1038/bmt.2012.244
    401 rdf:type schema:CreativeWork
    402 sg:pub.10.1038/modpathol.3800700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019137807
    403 https://doi.org/10.1038/modpathol.3800700
    404 rdf:type schema:CreativeWork
    405 sg:pub.10.1038/nrc1251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052855187
    406 https://doi.org/10.1038/nrc1251
    407 rdf:type schema:CreativeWork
    408 sg:pub.10.1038/sj.bjc.6600536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048736947
    409 https://doi.org/10.1038/sj.bjc.6600536
    410 rdf:type schema:CreativeWork
    411 sg:pub.10.1038/sj.bjc.6601531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028884561
    412 https://doi.org/10.1038/sj.bjc.6601531
    413 rdf:type schema:CreativeWork
    414 grid-institutes:None schema:alternateName Asahi-Matsumoto Hospital, Kitakyushu, 800-0242 Japan
    415 Laboratory of Pathology, Fukuoka Wajiro Hospital, Fukuoka, 811-0213 Japan
    416 schema:name Asahi-Matsumoto Hospital, Kitakyushu, 800-0242 Japan
    417 Department of Pathology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan
    418 Laboratory of Pathology, Fukuoka Wajiro Hospital, Fukuoka, 811-0213 Japan
    419 rdf:type schema:Organization
    420 grid-institutes:grid.258333.c schema:alternateName Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshima 890-8520 Japan
    421 schema:name Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshima 890-8520 Japan
    422 rdf:type schema:Organization
    423 grid-institutes:grid.271052.3 schema:alternateName Department of Dentistry and Oral Surgery, University Hospital of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
    424 Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
    425 Department of Occupational Pneumology, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
    426 Department of Pathology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan
    427 Department of Second Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
    428 Department of Urology, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
    429 Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
    430 Shared-Use Research Center, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
    431 schema:name Department of Dentistry and Oral Surgery, University Hospital of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
    432 Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
    433 Department of Occupational Pneumology, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
    434 Department of Pathology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan
    435 Department of Second Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
    436 Department of Urology, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
    437 Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
    438 Shared-Use Research Center, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
    439 rdf:type schema:Organization
    440 grid-institutes:grid.5110.5 schema:alternateName Institute of Molecular Biosciences, University of Graz, Graz, 8010 Austria
    441 schema:name Department of Pathology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan
    442 Institute of Molecular Biosciences, University of Graz, Graz, 8010 Austria
    443 Institute of Pathology, Medical University of Graz, Graz, 8010 Austria
    444 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...