Serum DLK1 is a potential prognostic biomarker in patients with hepatocellular carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-05-28

AUTHORS

Hong Li, Mei-ling Cui, Tao-yang Chen, Hai-yang Xie, Ying Cui, Hong Tu, Fu-hua Chen, Chao Ge, Jin-jun Li

ABSTRACT

Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer and the third most frequent cause of cancer-related death in developing countries, especially in East Asia and South Africa, and the identification of new biomarkers for early diagnosis and prognosis is needed. Delta-like 1 homologue (Drosophila) (DLK1) is expressed in malignancies and promotes cancer cell stemness and tumourigenicity, which makes this molecule a potential target for therapies directed against cancer stem/progenitor cells. Here, we aimed to assess the predictive value of DLK1 as a diagnostic and prognostic biomarker in HCC. With this purpose, serum DLK1 levels were detected using an enzyme-linked immunosorbent assay (ELISA) in serum specimens from 397 HCC patients, 114 healthy individuals, 43 patients with chronic hepatitis B virus (HBV) infection and 24 cirrhotic liver patients with HBV infection, and the correlation between DLK1 levels and clinical features was evaluated. Our data showed that the serum DLK1 level was significantly higher in HCC patients than in healthy individuals or patients with chronic HBV infection (HBV carriers) (P < 0.05). Moreover, the serum DLK1 levels were positively correlated with tumour size and α-fetoprotein (AFP) levels, but not with gender, age, histological grade, HBV infection, intrahepatic metastasis or cirrhosis in HCC patients. Kaplan–Meier analysis indicated that higher DLK1 levels were associated with shorter survival in HCC patients. These results suggest that the serum levels of DLK1 may serve as a prognostic biomarker for HCC patients. More... »

PAGES

8399-8404

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13277-015-3607-8

DOI

http://dx.doi.org/10.1007/s13277-015-3607-8

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26018510


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73 enzyme-linked immunosorbent assay
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81 histological grade
82 homologues
83 identification
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85 individuals
86 infection
87 intrahepatic metastasis
88 levels
89 liver patients
90 malignancy
91 metastasis
92 molecules
93 new biomarkers
94 patients
95 potential prognostic biomarker
96 potential target
97 predictive value
98 prevalent cancer
99 progenitor cells
100 prognosis
101 prognostic biomarker
102 purpose
103 results
104 serum levels
105 serum specimens
106 shorter survival
107 size
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109 stem/progenitor cells
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111 survival
112 target
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114 tumor size
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