The combination of a nuclear HMGB1-positive and HMGB2-negative expression is potentially associated with a shortened survival in patients with pancreatic ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-07-26

AUTHORS

Toru Takeda, Hiroto Izumi, Shohei Kitada, Hidetaka Uramoto, Takashi Tasaki, Li Zhi, Xin Guo, Yuichiro Kawatsu, Tomoko Kimura, Seichi Horie, Atsunori Nabeshima, Hirotsugu Noguchi, Ke-Yong Wang, Yasuyuki Sasaguri, Kimitoshi Kohno, Sohsuke Yamada

ABSTRACT

High-mobility group box (HMGB) proteins are ubiquitous, abundant nuclear non-histone chromosomal proteins that play a critical role in binding to distorted DNA structures and subsequently regulating DNA transcription, replication, repair, and recombination. Both HMGB1 and HMGB2 exhibit a high expression in several human cancers and are closely associated with tumor progression and a poor prognosis. However, the expression patterns of these molecules in pancreatic ductal adenocarcinoma (PDAC) remain to be elucidated. As most cases of postoperative relapse of PDAC occur within the first 2 years, the clinical significance of accurate biomarkers is needed. Therefore, we investigated the correlation between the immunohistochemical HMGB1 and HMGB2 expression and the clinicopathological characteristics and prognosis using 62 paraffin-embedded tumor samples obtained from patients with surgically resected PDAC. The HMGB1/2 expression was considered to be positive when 10 % or more of the cancer cells showed positive nuclear, not merely cytoplasmic, staining. Consequently, the expression of HMGB1/2 was observed in 54 (87.1 %) and 31 (50.0 %) patients, respectively. Unexpectedly, a positive HMGB1 expression was found to have a significantly close relationship with a negative HMGB2 expression. The univariate and multivariate analyses demonstrated that the patients with a HMGB1+ and HMGB2− status had markedly lower disease-specific survival rates, especially within the first 2 years postoperatively, whereas those with a HMGB1+ status alone did not. Therefore, the combination of a HMGB1+ and HMGB2− expression potentially predicts a poor prognosis in patients with PDAC, and these new biomarkers may be useful parameters for clinical management in the early postoperative phase. More... »

PAGES

10555-10569

References to SciGraph publications

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  • Journal

    TITLE

    Tumor Biology

    ISSUE

    10

    VOLUME

    35

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13277-014-2328-8

    DOI

    http://dx.doi.org/10.1007/s13277-014-2328-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041613308

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25060178


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