Brain tumor senescence might be mediated by downregulation of S-phase kinase-associated protein 2 via butylidenephthalide leading to decreased cell viability View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-05

AUTHORS

Mao-Hsuan Huang, Shinn-Zong Lin, Po-Cheng Lin, Tzyy-Wen Chiou, Yeu-Wei Harn, Li-Ing Ho, Tzu-Min Chan, Chih-Wei Chou, Chang-Han Chuang, Hong-Lin Su, Horng-Jyh Harn

ABSTRACT

Developing an effective drug for treating human glioblastoma multiform (GBM) has been investigated persistently. A pure compound butylidenephthalide (BP), isolated from Angelica sinensis, has been shown the activities to arrest the growth and initiate apoptosis of GBM in our previous reports. In this study, we further demonstrated that BP treatment accelerates the cell senescence in a dose-dependent manner in vitro and in vivo. S-phase kinase-associated protein 2 (Skp2), a proto-oncogene, is generally upregulated in cancer. We found that it was downregulated in BP-treated GBM cells. The downregulation of Skp2 is parallel with increasing p16 and p21 expression which causes G0/G1 arrest and tumor cell senescence. We also found that restoring the Skp2 protein level by exogenous overexpression prevents the BP-induced cell senescence. Therefore, the linkage between cell senescence and Skp2 expression is strengthened. Promoter binding analysis further detailed that the BP-mediated SP1 reduction might involve in the Skp2 downregulation. In summary, these results emphasize that BP-triggered senescence in GBM cells is highly associated with its control on Skp2 regulation. More... »

PAGES

4875-4884

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13277-014-1639-0

DOI

http://dx.doi.org/10.1007/s13277-014-1639-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047751059

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24464249


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13277-014-1639-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13277-014-1639-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13277-014-1639-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13277-014-1639-0'


 

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316 https://www.grid.ac/institutes/grid.412040.3 schema:alternateName National Cheng Kung University Hospital
317 schema:name Department of Orthopaedics, National Cheng Kung University Hospital, Tainan, Taiwan, China
318 rdf:type schema:Organization
319 https://www.grid.ac/institutes/grid.477298.7 schema:alternateName Stem Cell Technology (Taiwan)
320 schema:name Department of Research and Development, Gwo Xi Stem Cell Applied Technology Co., Ltd., Hsinchu, Taiwan, China
321 rdf:type schema:Organization
 




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