Transforming growth factor beta1 (TGFβ1) polymorphisms and breast cancer risk View Full Text


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Article Info

DATE

2014-01-15

AUTHORS

Davar Amani, Ahad Khalilnezhad, Abbas Ghaderi, Norrio Niikawa, Ko-ichiro Yoshiura

ABSTRACT

Transforming growth factor β1 (TGFβ1) is suggested to be involved in the pathogenesis of and in complications with breast cancer (BC). Polymorphisms in TGFβ1 gene (TGFβ1) have been suggested by many investigators to have a role in susceptibility to BC; however, many discordant data have been reported. Considering the role of ethnic variations, we performed an association study between TGFβ1 polymorphisms and BC among Iranian women. We sequenced DNA samples of 110 BC and 110 normal control women for the exons and their adjacent intronic regions of TGFβ1 using PCR. The allele, genotype, and haplotype frequencies were calculated using PowerMarker V3.25 and R 3.0.2 softwares. Ten single nucleotide polymorphisms (SNPs) were detected. Statistical analysis on the frequency of seven most frequent SNPs, including the three coding SNPs (cSNPs) revealed no significant difference between BC and control women. Moreover, among 11 constructed haplotypes, “GTGCCGC” was significantly different between two study groups. In conclusion, we found no association between the studied SNPs of TGFβ1 and BC among Iranian women, but a possible association between “GTGCCGC” haplotype and BC was seen. However, further studies are suggested to clarify this association. More... »

PAGES

4757-4764

References to SciGraph publications

  • 2007-09-11. TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study in BMC CANCER
  • 2011-08-25. Regulation of endothelial cell plasticity by TGF-β in CELL AND TISSUE RESEARCH
  • 2001-01. TGF-β Signaling in Mammary Gland Development and Tumorigenesis in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • 2005-03. Genetic polymorphisms of TGF-β1 & TNF-β and breast cancer risk in BREAST CANCER RESEARCH AND TREATMENT
  • 2011-03-11. Crosstalk of TGF-β and Estrogen Receptor Signaling in Breast Cancer in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • 2003-01. Transforming growth factor B1 T29C polymorphism and breast cancer risk in Japanese women in BREAST CANCER
  • 2010-03-27. Transforming growth factorβ1 L10P variant plays an active role on the breast cancer susceptibility in Caucasian: evidence from 10,392 cases and 11,697 controls in BREAST CANCER RESEARCH AND TREATMENT
  • 2010-04-02. Association of a TGF-β1 gene −509 C/T polymorphism with breast cancer risk: a meta-analysis in BREAST CANCER RESEARCH AND TREATMENT
  • 2010-06. TGFβ signalling: a complex web in cancer progression in NATURE REVIEWS CANCER
  • 2004-06-22. Analysis of polymorphic TGFB1codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults in BMC MEDICAL GENOMICS
  • 1986-05. Transforming growth factor β gene maps to human chromosome 19 long arm and to mouse chromosome 7 in SOMATIC CELL AND MOLECULAR GENETICS
  • 2007-02-11. A common coding variant in CASP8 is associated with breast cancer risk in NATURE GENETICS
  • 2012-08-05. TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy in NATURE IMMUNOLOGY
  • 2008-09-30. TGF-β1 genotype and phenotype in breast cancer and their associations with IGFs and patient survival in BRITISH JOURNAL OF CANCER
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    http://scigraph.springernature.com/pub.10.1007/s13277-014-1621-x

    DOI

    http://dx.doi.org/10.1007/s13277-014-1621-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011271806

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24425107


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