Association of COX2 gene hypomethylation with intestinal type gastric cancer in samples of patients from northern Brazil View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-09-07

AUTHORS

Cynthia Farias Vieira de Melo, Carolina Oliveira Gigek, Juarez Nóbrega da Silva, Marilia de Arruda Cardoso Smith, Rubistenia Miranda de Araújo, Rommel Rodríguez Burbano, Eleonidas Moura Lima

ABSTRACT

To verify the methylation status of THBS1, GPX3, and COX2 genes and to evaluate their association with Helicobacter pylori in gastric adenocarcinomas. Methylation-sensitive restriction enzyme PCR assay was performed in 16 diffuse type gastric cancer samples, 23 intestinal type, and 15 normal stomach tissue. The presence of H. pylori was performed by amplification of the fragment of the 16S rRNA. Statistical analyses were performed using Fisher’s exact test. The hypermethylation of GPX3, THBS1, and COX2 occurred in 18 (n = 7), 5 (n = 2), and 36 % (n = 14) of gastric cancer samples, respectively, whereas in normal samples, it was found in 13, 7, and 67 %. The presence of H. pylori was detected in 67 % of gastric cancer samples and 67 % in normal gastric samples. The methylation of THBS1 and GPX3 was not significantly different between the types of tumors, normal sample, the presence of H. pylori, or clinicopathological variables studied (P > 0.05). However, the methylation status of the gene COX2 is significantly different between normal tissue and intestinal type gastric cancer (P = 0.02). Therefore, our results suggest that the methylation status of the gene COX2 is associated with the intestinal type of gastric cancer. More... »

PAGES

1107-1111

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13277-013-1148-6

DOI

http://dx.doi.org/10.1007/s13277-013-1148-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014781181

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24014049


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