Ontology type: schema:ScholarlyArticle Open Access: True
2012-01-21
AUTHORSGuus A. M. S. van Dongen, Alex J. Poot, Danielle J. Vugts
ABSTRACTDuring the last decade, the discovery of critical tumor targets has boosted the design of targeted therapeutic agents with monoclonal antibodies (mAbs) and tyrosine kinase inhibitors (TKIs) receiving most of the attention. Immuno-positron emission tomography (immuno-PET) and TKI-PET, the in vivo tracking and quantification of mAbs and TKIs biodistribution with PET, are exciting novel options for better understanding of the in vivo behavior and efficacy of these targeted drugs in individual patients and for more efficient drug development. Very recently, current good manufacturing practice compliant procedures for labeling of mAbs with positron emitters have been described, as well as the preparation of some radiolabeled TKIs, while the first proof of principle studies has been performed in patients. In this review, technical developments in immuno-PET and TKI-PET are described, and their clinical potential is discussed. An overview is provided for the most appealing preclinical immuno-PET and TKI-PET studies, as well as the first clinical achievements with these emerging technologies. More... »
PAGES607-615
http://scigraph.springernature.com/pub.10.1007/s13277-012-0316-4
DOIhttp://dx.doi.org/10.1007/s13277-012-0316-4
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1023969082
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/22270450
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Monoclonal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Evaluation, Preclinical",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunoconjugates",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Molecular Targeted Therapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Positron-Emission Tomography",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein Kinase Inhibitors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein-Tyrosine Kinases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Radioisotopes",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Nuclear Medicine and PET Research, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands",
"Department of Nuclear Medicine and PET Research, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "van Dongen",
"givenName": "Guus A. M. S.",
"id": "sg:person.0732223564.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732223564.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Nuclear Medicine and PET Research, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands",
"Department of Nuclear Medicine and PET Research, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Poot",
"givenName": "Alex J.",
"id": "sg:person.01070325626.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070325626.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Nuclear Medicine and PET Research, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands",
"Department of Nuclear Medicine and PET Research, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Vugts",
"givenName": "Danielle J.",
"id": "sg:person.0665425270.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665425270.49"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s00259-009-1263-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005085942",
"https://doi.org/10.1007/s00259-009-1263-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11307-009-0265-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013417972",
"https://doi.org/10.1007/s11307-009-0265-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/clpt.2010.12",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037850597",
"https://doi.org/10.1038/clpt.2010.12"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00259-007-0636-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007708046",
"https://doi.org/10.1007/s00259-007-0636-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00259-011-1930-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034481588",
"https://doi.org/10.1007/s00259-011-1930-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nprot.2010.13",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015342974",
"https://doi.org/10.1038/nprot.2010.13"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00259-006-0160-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024198485",
"https://doi.org/10.1007/s00259-006-0160-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00259-009-1096-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035603726",
"https://doi.org/10.1007/s00259-009-1096-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt0910-917",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022386882",
"https://doi.org/10.1038/nbt0910-917"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00259-008-0774-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017151871",
"https://doi.org/10.1007/s00259-008-0774-5"
],
"type": "CreativeWork"
}
],
"datePublished": "2012-01-21",
"datePublishedReg": "2012-01-21",
"description": "During the last decade, the discovery of critical tumor targets has boosted the design of targeted therapeutic agents with monoclonal antibodies (mAbs) and tyrosine kinase inhibitors (TKIs) receiving most of the attention. Immuno-positron emission tomography (immuno-PET) and TKI-PET, the in vivo tracking and quantification of mAbs and TKIs biodistribution with PET, are exciting novel options for better understanding of the in vivo behavior and efficacy of these targeted drugs in individual patients and for more efficient drug development. Very recently, current good manufacturing practice compliant procedures for labeling of mAbs with positron emitters have been described, as well as the preparation of some radiolabeled TKIs, while the first proof of principle studies has been performed in patients. In this review, technical developments in immuno-PET and TKI-PET are described, and their clinical potential is discussed. An overview is provided for the most appealing preclinical immuno-PET and TKI-PET studies, as well as the first clinical achievements with these emerging technologies.",
"genre": "article",
"id": "sg:pub.10.1007/s13277-012-0316-4",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1091981",
"issn": [
"1010-4283",
"1423-0380"
],
"name": "Tumor Biology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "33"
}
],
"keywords": [
"tyrosine kinase inhibitors",
"immuno-PET",
"kinase inhibitors",
"immuno-positron emission tomography",
"targeted therapeutic agents",
"labeling of MAbs",
"quantification of mAbs",
"efficient drug development",
"Radiolabeled Antibodies",
"individual patients",
"tumor targets",
"emission tomography",
"clinical achievements",
"therapeutic agents",
"monoclonal antibodies",
"clinical potential",
"compliant procedures",
"novel option",
"patients",
"drug development",
"vivo tracking",
"antibodies",
"mAbs",
"inhibitors",
"vivo behavior",
"PET",
"drugs",
"efficacy",
"tomography",
"biodistribution",
"study",
"positron emitters",
"better understanding",
"review",
"options",
"agents",
"last decade",
"target",
"development",
"labeling",
"first proof",
"procedure",
"principle study",
"technical developments",
"discovery",
"quantification",
"potential",
"preparation",
"decades",
"overview",
"understanding",
"attention",
"behavior",
"design",
"achievement",
"proof",
"tracking",
"technology",
"emitters"
],
"name": "PET imaging with radiolabeled antibodies and tyrosine kinase inhibitors: immuno-PET and TKI-PET",
"pagination": "607-615",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1023969082"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s13277-012-0316-4"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"22270450"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s13277-012-0316-4",
"https://app.dimensions.ai/details/publication/pub.1023969082"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:28",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_567.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s13277-012-0316-4"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13277-012-0316-4'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13277-012-0316-4'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13277-012-0316-4'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13277-012-0316-4'
This table displays all metadata directly associated to this object as RDF triples.
220 TRIPLES
22 PREDICATES
106 URIs
88 LITERALS
18 BLANK NODES