Ontology type: schema:ScholarlyArticle
2010-06
AUTHORSSang-eun Lee, Ik-soon Jang, Jun-soo Park, Ji-Hae Lee, Seung-Yeul Lee, So-young Baek, Seung-hoon Lee, Hyunah Lee
ABSTRACTObesity has recently been defined as a chronic inflammatory disease and is considered as a major cause of adult health problems including incurable diseases like diabetes and cancer. In this study, the systemic immunity, including the innate and adaptive immunity parameters, of naturally occurring (leptin receptor mutation) obesity-diabetes mice (db/db) was examined to increase our knowledge of these mice for obesity-related studies. Severe fatty liver with blood engorgement was observed in the db/db mice. Compared to background C57BL/6J mice, the adaptive immunity, as measured by mitogen-induced T and B cell proliferation and cytokine release, was significantly suppressed in db/db mice. However, significant upregulation of innate immune-inflammatory parameters including macrophage function and NK cell activity was observed in db/db mice without external stimulation. These data conclusively confirm the systemic immune-inflammatory micro-environment with suppressed adaptive immunity of db/db mice, which may cause the secondary obesity-related life-threatening diseases like diabetes or cancer. More... »
PAGES143-149
http://scigraph.springernature.com/pub.10.1007/s13273-010-0021-6
DOIhttp://dx.doi.org/10.1007/s13273-010-0021-6
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1000817438
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Clinical Research Institute, Samsung Medical Center Sungkyunkwan University School of Medicine, 50 IL-Won Dong, Gang-Nam Gu, 135-710, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.264381.a",
"name": [
"Clinical Research Institute, Samsung Medical Center Sungkyunkwan University School of Medicine, 50 IL-Won Dong, Gang-Nam Gu, 135-710, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Sang-eun",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Korea Basic Science Institute, 305-333, Daejeon, Korea",
"id": "http://www.grid.ac/institutes/grid.410885.0",
"name": [
"Korea Basic Science Institute, 305-333, Daejeon, Korea"
],
"type": "Organization"
},
"familyName": "Jang",
"givenName": "Ik-soon",
"id": "sg:person.01317070447.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317070447.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Biological Sciences and Technology, Yonsei University, 220-701, Wonju, Korea",
"id": "http://www.grid.ac/institutes/grid.15444.30",
"name": [
"Division of Biological Sciences and Technology, Yonsei University, 220-701, Wonju, Korea"
],
"type": "Organization"
},
"familyName": "Park",
"givenName": "Jun-soo",
"id": "sg:person.01101756254.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101756254.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Life Science, Yong-In University, 470 Samga Dong, Cheoin Gu, 449-714, YongIn, Korea",
"id": "http://www.grid.ac/institutes/grid.444164.7",
"name": [
"Department of Life Science, Yong-In University, 470 Samga Dong, Cheoin Gu, 449-714, YongIn, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Ji-Hae",
"id": "sg:person.0602730021.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602730021.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Life Science, Yong-In University, 470 Samga Dong, Cheoin Gu, 449-714, YongIn, Korea",
"id": "http://www.grid.ac/institutes/grid.444164.7",
"name": [
"Department of Life Science, Yong-In University, 470 Samga Dong, Cheoin Gu, 449-714, YongIn, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Seung-Yeul",
"id": "sg:person.0671703254.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671703254.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Clinical Research Institute, Samsung Medical Center Sungkyunkwan University School of Medicine, 50 IL-Won Dong, Gang-Nam Gu, 135-710, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.264381.a",
"name": [
"Clinical Research Institute, Samsung Medical Center Sungkyunkwan University School of Medicine, 50 IL-Won Dong, Gang-Nam Gu, 135-710, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Baek",
"givenName": "So-young",
"id": "sg:person.01060267400.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060267400.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Life Science, Yong-In University, 470 Samga Dong, Cheoin Gu, 449-714, YongIn, Korea",
"id": "http://www.grid.ac/institutes/grid.444164.7",
"name": [
"Department of Life Science, Yong-In University, 470 Samga Dong, Cheoin Gu, 449-714, YongIn, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Seung-hoon",
"id": "sg:person.016714712721.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016714712721.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Clinical Research Institute, Samsung Medical Center Sungkyunkwan University School of Medicine, 50 IL-Won Dong, Gang-Nam Gu, 135-710, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.264381.a",
"name": [
"Clinical Research Institute, Samsung Medical Center Sungkyunkwan University School of Medicine, 50 IL-Won Dong, Gang-Nam Gu, 135-710, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Hyunah",
"id": "sg:person.01100771052.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100771052.17"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/sj.ijo.0803002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039461754",
"https://doi.org/10.1038/sj.ijo.0803002"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.ejcn.1601324",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048908490",
"https://doi.org/10.1038/sj.ejcn.1601324"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2119/2008-00038.nathan",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077638929",
"https://doi.org/10.2119/2008-00038.nathan"
],
"type": "CreativeWork"
}
],
"datePublished": "2010-06",
"datePublishedReg": "2010-06-01",
"description": "Obesity has recently been defined as a chronic inflammatory disease and is considered as a major cause of adult health problems including incurable diseases like diabetes and cancer. In this study, the systemic immunity, including the innate and adaptive immunity parameters, of naturally occurring (leptin receptor mutation) obesity-diabetes mice (db/db) was examined to increase our knowledge of these mice for obesity-related studies. Severe fatty liver with blood engorgement was observed in the db/db mice. Compared to background C57BL/6J mice, the adaptive immunity, as measured by mitogen-induced T and B cell proliferation and cytokine release, was significantly suppressed in db/db mice. However, significant upregulation of innate immune-inflammatory parameters including macrophage function and NK cell activity was observed in db/db mice without external stimulation. These data conclusively confirm the systemic immune-inflammatory micro-environment with suppressed adaptive immunity of db/db mice, which may cause the secondary obesity-related life-threatening diseases like diabetes or cancer.",
"genre": "article",
"id": "sg:pub.10.1007/s13273-010-0021-6",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1040680",
"issn": [
"1738-642X",
"2092-8467"
],
"name": "Molecular & Cellular Toxicology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "6"
}
],
"keywords": [
"db/db mice",
"db mice",
"systemic immunity",
"adaptive immunity",
"adaptive immunity parameters",
"immune-inflammatory parameters",
"NK cell activity",
"chronic inflammatory disease",
"severe fatty liver",
"adult health problems",
"life-threatening disease",
"B cell proliferation",
"fatty liver",
"cytokine release",
"model mice",
"inflammatory diseases",
"immunity parameters",
"macrophage function",
"obesity-related studies",
"health problems",
"incurable disease",
"cell activity",
"mice",
"blood engorgement",
"major cause",
"significant upregulation",
"immunity",
"disease",
"cell proliferation",
"diabetes",
"cancer",
"obesity",
"external stimulation",
"liver",
"engorgement",
"upregulation",
"stimulation",
"proliferation",
"cause",
"study",
"release",
"activity",
"background",
"function",
"data",
"knowledge",
"parameters",
"problem"
],
"name": "Systemic immunity of obese-diabetes model (db/db) mice",
"pagination": "143-149",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1000817438"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s13273-010-0021-6"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s13273-010-0021-6",
"https://app.dimensions.ai/details/publication/pub.1000817438"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T10:03",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_520.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s13273-010-0021-6"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13273-010-0021-6'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13273-010-0021-6'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13273-010-0021-6'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13273-010-0021-6'
This table displays all metadata directly associated to this object as RDF triples.
175 TRIPLES
22 PREDICATES
77 URIs
66 LITERALS
6 BLANK NODES