Systemic immunity of obese-diabetes model (db/db) mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-06

AUTHORS

Sang-eun Lee, Ik-soon Jang, Jun-soo Park, Ji-Hae Lee, Seung-Yeul Lee, So-young Baek, Seung-hoon Lee, Hyunah Lee

ABSTRACT

Obesity has recently been defined as a chronic inflammatory disease and is considered as a major cause of adult health problems including incurable diseases like diabetes and cancer. In this study, the systemic immunity, including the innate and adaptive immunity parameters, of naturally occurring (leptin receptor mutation) obesity-diabetes mice (db/db) was examined to increase our knowledge of these mice for obesity-related studies. Severe fatty liver with blood engorgement was observed in the db/db mice. Compared to background C57BL/6J mice, the adaptive immunity, as measured by mitogen-induced T and B cell proliferation and cytokine release, was significantly suppressed in db/db mice. However, significant upregulation of innate immune-inflammatory parameters including macrophage function and NK cell activity was observed in db/db mice without external stimulation. These data conclusively confirm the systemic immune-inflammatory micro-environment with suppressed adaptive immunity of db/db mice, which may cause the secondary obesity-related life-threatening diseases like diabetes or cancer. More... »

PAGES

143-149

References to SciGraph publications

  • 2005-05-24. Cytokine release from adipose tissue of nonobese individuals in INTERNATIONAL JOURNAL OF OBESITY
  • 2002-03-27. Effect of obesity and insulin on immunity in non-insulin-dependent diabetes mellitus in EUROPEAN JOURNAL OF CLINICAL NUTRITION
  • 2008-04-10. Epidemic Inflammation: Pondering Obesity in MOLECULAR MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13273-010-0021-6

    DOI

    http://dx.doi.org/10.1007/s13273-010-0021-6

    DIMENSIONS

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