Ontology type: schema:ScholarlyArticle
2018-06
AUTHORSBindu Subhadra, Dong Ho Kim, Jaeseok Kim, Kyungho Woo, Kyung Mok Sohn, Hwa-Jung Kim, Kyudong Han, Man Hwan Oh, Chul Hee Choi
ABSTRACTUrinary tract infections (UTIs) are among the most common infections in humans, predominantly caused by uropathogenic Escherichia coli (UPEC). The diverse genomes of UPEC strains mostly impede disease prevention and control measures. In this study, we comparatively analyzed the whole genome sequence of a highly virulent UPEC strain, namely UPEC 26-1, which was isolated from urine sample of a patient suffering from UTI in Korea. Whole genome analysis showed that the genome consists of one circular chromosome of 5,329,753 bp, comprising 5064 protein-coding genes, 122 RNA genes (94 tRNA, 22 rRNA and 6 ncRNA genes), and 100 pseudogenes, with an average G+C content of 50.56%. In addition, we identified 8 prophage regions comprising 5 intact, 2 incomplete and 1 questionable ones and 63 genomic islands, suggesting the possibility of horizontal gene transfer in this strain. Comparative genome analysis of UPEC 26-1 with the UPEC strain CFT073 revealed an average nucleotide identity of 99.7%. The genome comparison with CFT073 provides major differences in the genome of UPEC 26-1 that would explain its increased virulence and biofilm formation. Nineteen of the total GIs were unique to UPEC 26-1 compared to CFT073 and nine of them harbored unique genes that are involved in virulence, multidrug resistance, biofilm formation and bacterial pathogenesis. The data from this study will assist in future studies of UPEC strains to develop effective control measures. More... »
PAGES643-655
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DOIhttp://dx.doi.org/10.1007/s13258-018-0665-5
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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13258-018-0665-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13258-018-0665-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13258-018-0665-5'
This table displays all metadata directly associated to this object as RDF triples.
317 TRIPLES
21 PREDICATES
83 URIs
36 LITERALS
24 BLANK NODES