In vivo evidence on the functional variation within fatty acid synthase gene associated with lipid metabolism in bovine longissimus dorsi ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-03

AUTHORS

Dong-yep Oh, Insik Nam, Sehwan Hwang, Hongsik Kong, Honggu Lee, Jaejung Ha, Myunggi Baik, Man Hwan Oh, Songmi Kim, Kyudong Han, Yoonseok Lee

ABSTRACT

In Korean cattle, intramuscular fat (IMF), or marbling, of the longissimus dorsi muscle (LM) cross section is one of the most important indicators of beef quality and are influenced by environmental and genetic factors. This study was to evaluate the effect of SNPs on the beef quality in Korean cattle for functional studies, such as site-directed mutagenesis based on bovine adipocytes. The fatty acid synthase (FASN) gene plays an important role in lipogenesis. FASN is an essential metabolic and multifunctional enzyme in fatty acid synthesis. Several studies have reported that SNPs g.841G, g.16024A, g.16039T, and g.17924G have a significant impact on marbling scores in Korean cattle and Japanese Black cattle population. These SNPs are located in transcription factor binding sites, the beta-ketoacyl reductase, and thioesterase domains. Our results revealed that the g.17924 A>G SNP is located in the thioesterase domain of the FASN protein, and changes from polar, neutral, and hydrophilic to nonpolar, aliphatic, and hydrophobic, respectively. In in vivo LM tissue of Korean cattle, the g.17924A>G SNP has an effect on increasing fat deposition. Therefore, g.17924A>G SNP could be a causal mutation for increasing fat deposition in Korean cattle LM tissue. More... »

PAGES

289-294

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13258-017-0634-4

DOI

http://dx.doi.org/10.1007/s13258-017-0634-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092806008

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29892799


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipose Tissue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Fat Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cattle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acid Synthase, Type I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipid Metabolism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Meat", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Red Meat", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Livestock Research Institute, Gyeongsangbuk-Do, 36052, Yeongju, Gyeongbuk, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "Dong-yep", 
        "id": "sg:person.012536711642.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012536711642.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hankyong National University", 
          "id": "https://www.grid.ac/institutes/grid.411968.3", 
          "name": [
            "Research Center for Environment Friendly and Quality Livestock Production Technology, Hankyong National University, 17579, Anseong, Gyeonggi, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nam", 
        "givenName": "Insik", 
        "id": "sg:person.0721670212.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721670212.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hankyong National University", 
          "id": "https://www.grid.ac/institutes/grid.411968.3", 
          "name": [
            "Department of Biotechnology, College of Agriculture & Life Science, Hankyong National University, 17579, Anseong, Gyeonggi, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hwang", 
        "givenName": "Sehwan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hankyong National University", 
          "id": "https://www.grid.ac/institutes/grid.411968.3", 
          "name": [
            "Department of Biotechnology, College of Agriculture & Life Science, Hankyong National University, 17579, Anseong, Gyeonggi, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kong", 
        "givenName": "Hongsik", 
        "id": "sg:person.01110727234.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110727234.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Konkuk University", 
          "id": "https://www.grid.ac/institutes/grid.258676.8", 
          "name": [
            "Department of Animal Science and Technology, Sanghuh College of Life Sciences, Konkuk University, 05029, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Honggu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Livestock Research Institute, Gyeongsangbuk-Do, 36052, Yeongju, Gyeongbuk, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ha", 
        "givenName": "Jaejung", 
        "id": "sg:person.01276133560.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276133560.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, 08826, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baik", 
        "givenName": "Myunggi", 
        "id": "sg:person.01060612024.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060612024.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dankook University", 
          "id": "https://www.grid.ac/institutes/grid.411982.7", 
          "name": [
            "Department of Nanobiomedical Science, Dankook University, 31116, Cheonan, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "Man Hwan", 
        "id": "sg:person.01136422063.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136422063.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dankook University", 
          "id": "https://www.grid.ac/institutes/grid.411982.7", 
          "name": [
            "Department of Nanobiomedical Science, Dankook University, 31116, Cheonan, Republic of Korea", 
            "BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, 31116, Cheonan, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Songmi", 
        "id": "sg:person.011324711521.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011324711521.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dankook University", 
          "id": "https://www.grid.ac/institutes/grid.411982.7", 
          "name": [
            "Department of Nanobiomedical Science, Dankook University, 31116, Cheonan, Republic of Korea", 
            "BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, 31116, Cheonan, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Kyudong", 
        "id": "sg:person.01333145216.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333145216.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hankyong National University", 
          "id": "https://www.grid.ac/institutes/grid.411968.3", 
          "name": [
            "Department of Biotechnology, College of Agriculture & Life Science, Hankyong National University, 17579, Anseong, Gyeonggi, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Yoonseok", 
        "id": "sg:person.01131147232.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131147232.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.livsci.2014.04.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005746949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abbi.2000.2153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006718533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-1119(99)00357-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009699405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2156-9-33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015994257", 
          "https://doi.org/10.1186/1471-2156-9-33"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10528-009-9235-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019001734", 
          "https://doi.org/10.1007/s10528-009-9235-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10528-009-9235-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019001734", 
          "https://doi.org/10.1007/s10528-009-9235-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10528-009-9235-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019001734", 
          "https://doi.org/10.1007/s10528-009-9235-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.020605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020775227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiolgenomics.00043.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027765042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000085672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031090778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000085672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031090778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2052.2009.01940.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032415155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11033-011-1190-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036446986", 
          "https://doi.org/10.1007/s11033-011-1190-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5713/ajas.2012.12078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039288554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/pns2003248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044780368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/asj.12357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047094530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2052.2007.01681.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047570134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2052.2011.02217.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051251723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2527/jas.2008-1427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070886700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2527/jas.2010-3121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070887472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2527/jas.2011-4753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070888208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5713/ajas.2007.466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073086573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5713/ajas.2009.80573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073087033"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-03", 
    "datePublishedReg": "2018-03-01", 
    "description": "In Korean cattle, intramuscular fat (IMF), or marbling, of the longissimus dorsi muscle (LM) cross section is one of the most important indicators of beef quality and are influenced by environmental and genetic factors. This study was to evaluate the effect of SNPs on the beef quality in Korean cattle for functional studies, such as site-directed mutagenesis based on bovine adipocytes. The fatty acid synthase (FASN) gene plays an important role in lipogenesis. FASN is an essential metabolic and multifunctional enzyme in fatty acid synthesis. Several studies have reported that SNPs g.841G, g.16024A, g.16039T, and g.17924G have a significant impact on marbling scores in Korean cattle and Japanese Black cattle population. These SNPs are located in transcription factor binding sites, the beta-ketoacyl reductase, and thioesterase domains. Our results revealed that the g.17924 A>G SNP is located in the thioesterase domain of the FASN protein, and changes from polar, neutral, and hydrophilic to nonpolar, aliphatic, and hydrophobic, respectively. In in vivo LM tissue of Korean cattle, the g.17924A>G SNP has an effect on increasing fat deposition. Therefore, g.17924A>G SNP could be a causal mutation for increasing fat deposition in Korean cattle LM tissue.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s13258-017-0634-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1040407", 
        "issn": [
          "0254-5934", 
          "2092-9293"
        ], 
        "name": "Genes & Genomics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "40"
      }
    ], 
    "name": "In vivo evidence on the functional variation within fatty acid synthase gene associated with lipid metabolism in bovine longissimus dorsi muscle tissue", 
    "pagination": "289-294", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1e5571732fb87590de8f8cf4aa4741eb9b941a6015ca3a5055788f9f55b42b54"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29892799"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101481027"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13258-017-0634-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092806008"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13258-017-0634-4", 
      "https://app.dimensions.ai/details/publication/pub.1092806008"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000565.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s13258-017-0634-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13258-017-0634-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13258-017-0634-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13258-017-0634-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13258-017-0634-4'


 

This table displays all metadata directly associated to this object as RDF triples.

271 TRIPLES      21 PREDICATES      63 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13258-017-0634-4 schema:about N0eeb6628dcd64057916fdc14388a941c
2 N16aecc85ba1c4c64a615801e1c2e86c6
3 N1bf7a7c67e26412b8130f660aa362ea4
4 N23874d66dcc147a5abe86106501cd3cb
5 N2767f81e595942da9e6e223b0d6d138b
6 N2e91fe197c4d434aa67bd07ac9b607d8
7 N4a84579ff6664c0d9c1d47e1c610caaf
8 N6777510fbb444beeb17f0cac3fc81912
9 N732ec277a6da48a2a74f26f1bf03802b
10 N7668519a94374565805050cfddf919ec
11 N894df44d82d5409f96c1b29e95573a2f
12 Nb5e75e458ad042559c9423bca09dadbe
13 Nbd2ac2f518ce4b31ab9ca1380fe5ece9
14 Nc5ef461e40f7456a87d314a4e7a44e20
15 anzsrc-for:06
16 anzsrc-for:0601
17 schema:author N8cd665bb087847f39ced5b6d2f9b059d
18 schema:citation sg:pub.10.1007/s10528-009-9235-5
19 sg:pub.10.1007/s11033-011-1190-7
20 sg:pub.10.1186/1471-2156-9-33
21 https://doi.org/10.1006/abbi.2000.2153
22 https://doi.org/10.1016/j.livsci.2014.04.006
23 https://doi.org/10.1016/s0378-1119(99)00357-1
24 https://doi.org/10.1079/pns2003248
25 https://doi.org/10.1111/asj.12357
26 https://doi.org/10.1111/j.1365-2052.2007.01681.x
27 https://doi.org/10.1111/j.1365-2052.2009.01940.x
28 https://doi.org/10.1111/j.1365-2052.2011.02217.x
29 https://doi.org/10.1152/physiolgenomics.00043.2008
30 https://doi.org/10.1159/000085672
31 https://doi.org/10.1359/jbmr.020605
32 https://doi.org/10.2527/jas.2008-1427
33 https://doi.org/10.2527/jas.2010-3121
34 https://doi.org/10.2527/jas.2011-4753
35 https://doi.org/10.5713/ajas.2007.466
36 https://doi.org/10.5713/ajas.2009.80573
37 https://doi.org/10.5713/ajas.2012.12078
38 schema:datePublished 2018-03
39 schema:datePublishedReg 2018-03-01
40 schema:description In Korean cattle, intramuscular fat (IMF), or marbling, of the longissimus dorsi muscle (LM) cross section is one of the most important indicators of beef quality and are influenced by environmental and genetic factors. This study was to evaluate the effect of SNPs on the beef quality in Korean cattle for functional studies, such as site-directed mutagenesis based on bovine adipocytes. The fatty acid synthase (FASN) gene plays an important role in lipogenesis. FASN is an essential metabolic and multifunctional enzyme in fatty acid synthesis. Several studies have reported that SNPs g.841G, g.16024A, g.16039T, and g.17924G have a significant impact on marbling scores in Korean cattle and Japanese Black cattle population. These SNPs are located in transcription factor binding sites, the beta-ketoacyl reductase, and thioesterase domains. Our results revealed that the g.17924 A>G SNP is located in the thioesterase domain of the FASN protein, and changes from polar, neutral, and hydrophilic to nonpolar, aliphatic, and hydrophobic, respectively. In in vivo LM tissue of Korean cattle, the g.17924A>G SNP has an effect on increasing fat deposition. Therefore, g.17924A>G SNP could be a causal mutation for increasing fat deposition in Korean cattle LM tissue.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree false
44 schema:isPartOf N1e06f2fd0a38409fb1888602c9dff3b5
45 Nf451c1cd13914d7b9d9b63288898b3c6
46 sg:journal.1040407
47 schema:name In vivo evidence on the functional variation within fatty acid synthase gene associated with lipid metabolism in bovine longissimus dorsi muscle tissue
48 schema:pagination 289-294
49 schema:productId N403fc9378d534ba896885c4742eff957
50 N6c24a01b0f6b4d11a7307578dd4fa208
51 N879b640fa1dd486390f5085270929942
52 Nded61e61252f42dea76088b3dccc33ed
53 Ne213ab9b93ca4670ba5636d3126e11b2
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092806008
55 https://doi.org/10.1007/s13258-017-0634-4
56 schema:sdDatePublished 2019-04-10T15:10
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N7fe551524bf34f108521f2538b404276
59 schema:url http://link.springer.com/10.1007/s13258-017-0634-4
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N0eeb6628dcd64057916fdc14388a941c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Body Fat Distribution
65 rdf:type schema:DefinedTerm
66 N0efcc05d7a014de6800cf46d0ae5cb9c rdf:first sg:person.01060612024.49
67 rdf:rest N20670d6f5a694e728fdf8f0a153e1535
68 N14dc94e57fb542b095125008015652f0 rdf:first N3768d5e90e0941a39ad60bfa07268caa
69 rdf:rest N3a7112433fc643b099ca6fa61ef91511
70 N16aecc85ba1c4c64a615801e1c2e86c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Adipose Tissue
72 rdf:type schema:DefinedTerm
73 N1bf7a7c67e26412b8130f660aa362ea4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Lipid Metabolism
75 rdf:type schema:DefinedTerm
76 N1e06f2fd0a38409fb1888602c9dff3b5 schema:issueNumber 3
77 rdf:type schema:PublicationIssue
78 N20670d6f5a694e728fdf8f0a153e1535 rdf:first sg:person.01136422063.84
79 rdf:rest N4209951fcf504e3a99143cde6f1d9928
80 N23874d66dcc147a5abe86106501cd3cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Muscle, Skeletal
82 rdf:type schema:DefinedTerm
83 N2767f81e595942da9e6e223b0d6d138b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Red Meat
85 rdf:type schema:DefinedTerm
86 N2e91fe197c4d434aa67bd07ac9b607d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Fatty Acid Synthase, Type I
88 rdf:type schema:DefinedTerm
89 N3768d5e90e0941a39ad60bfa07268caa schema:affiliation https://www.grid.ac/institutes/grid.411968.3
90 schema:familyName Hwang
91 schema:givenName Sehwan
92 rdf:type schema:Person
93 N3a7112433fc643b099ca6fa61ef91511 rdf:first sg:person.01110727234.99
94 rdf:rest N6186be48b77a4fbd92f007ec2388b60d
95 N403fc9378d534ba896885c4742eff957 schema:name pubmed_id
96 schema:value 29892799
97 rdf:type schema:PropertyValue
98 N4209951fcf504e3a99143cde6f1d9928 rdf:first sg:person.011324711521.77
99 rdf:rest N7c8006bb3d08426391457eb7068a0107
100 N4a84579ff6664c0d9c1d47e1c610caaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Adipocytes
102 rdf:type schema:DefinedTerm
103 N55c8b3e6f4c44217864880e5385dc117 schema:name Livestock Research Institute, Gyeongsangbuk-Do, 36052, Yeongju, Gyeongbuk, Republic of Korea
104 rdf:type schema:Organization
105 N6186be48b77a4fbd92f007ec2388b60d rdf:first Ne113aa82d084438e90097d159978a556
106 rdf:rest N6af793ae5f92432792ad68e8d478d60d
107 N6777510fbb444beeb17f0cac3fc81912 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Lipogenesis
109 rdf:type schema:DefinedTerm
110 N6af793ae5f92432792ad68e8d478d60d rdf:first sg:person.01276133560.77
111 rdf:rest N0efcc05d7a014de6800cf46d0ae5cb9c
112 N6c24a01b0f6b4d11a7307578dd4fa208 schema:name nlm_unique_id
113 schema:value 101481027
114 rdf:type schema:PropertyValue
115 N732ec277a6da48a2a74f26f1bf03802b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Fatty Acids
117 rdf:type schema:DefinedTerm
118 N7668519a94374565805050cfddf919ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Cattle
120 rdf:type schema:DefinedTerm
121 N7c8006bb3d08426391457eb7068a0107 rdf:first sg:person.01333145216.07
122 rdf:rest Ndb8bc834559944a794c16ec52ef8d789
123 N7fe551524bf34f108521f2538b404276 schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 N879b640fa1dd486390f5085270929942 schema:name readcube_id
126 schema:value 1e5571732fb87590de8f8cf4aa4741eb9b941a6015ca3a5055788f9f55b42b54
127 rdf:type schema:PropertyValue
128 N894df44d82d5409f96c1b29e95573a2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Meat
130 rdf:type schema:DefinedTerm
131 N8cd665bb087847f39ced5b6d2f9b059d rdf:first sg:person.012536711642.06
132 rdf:rest N9b1d155749d049dd8572f1432d1b85a9
133 N9b1d155749d049dd8572f1432d1b85a9 rdf:first sg:person.0721670212.07
134 rdf:rest N14dc94e57fb542b095125008015652f0
135 Nb5e75e458ad042559c9423bca09dadbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Animals
137 rdf:type schema:DefinedTerm
138 Nbd2ac2f518ce4b31ab9ca1380fe5ece9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Adipogenesis
140 rdf:type schema:DefinedTerm
141 Nc4aa5458702147d9a1efaf9c2731d10e schema:name Livestock Research Institute, Gyeongsangbuk-Do, 36052, Yeongju, Gyeongbuk, Republic of Korea
142 rdf:type schema:Organization
143 Nc5ef461e40f7456a87d314a4e7a44e20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Polymorphism, Single Nucleotide
145 rdf:type schema:DefinedTerm
146 Ndb8bc834559944a794c16ec52ef8d789 rdf:first sg:person.01131147232.99
147 rdf:rest rdf:nil
148 Nded61e61252f42dea76088b3dccc33ed schema:name doi
149 schema:value 10.1007/s13258-017-0634-4
150 rdf:type schema:PropertyValue
151 Ne113aa82d084438e90097d159978a556 schema:affiliation https://www.grid.ac/institutes/grid.258676.8
152 schema:familyName Lee
153 schema:givenName Honggu
154 rdf:type schema:Person
155 Ne213ab9b93ca4670ba5636d3126e11b2 schema:name dimensions_id
156 schema:value pub.1092806008
157 rdf:type schema:PropertyValue
158 Nf451c1cd13914d7b9d9b63288898b3c6 schema:volumeNumber 40
159 rdf:type schema:PublicationVolume
160 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
161 schema:name Biological Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
164 schema:name Biochemistry and Cell Biology
165 rdf:type schema:DefinedTerm
166 sg:journal.1040407 schema:issn 0254-5934
167 2092-9293
168 schema:name Genes & Genomics
169 rdf:type schema:Periodical
170 sg:person.01060612024.49 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
171 schema:familyName Baik
172 schema:givenName Myunggi
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060612024.49
174 rdf:type schema:Person
175 sg:person.01110727234.99 schema:affiliation https://www.grid.ac/institutes/grid.411968.3
176 schema:familyName Kong
177 schema:givenName Hongsik
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110727234.99
179 rdf:type schema:Person
180 sg:person.01131147232.99 schema:affiliation https://www.grid.ac/institutes/grid.411968.3
181 schema:familyName Lee
182 schema:givenName Yoonseok
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131147232.99
184 rdf:type schema:Person
185 sg:person.011324711521.77 schema:affiliation https://www.grid.ac/institutes/grid.411982.7
186 schema:familyName Kim
187 schema:givenName Songmi
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011324711521.77
189 rdf:type schema:Person
190 sg:person.01136422063.84 schema:affiliation https://www.grid.ac/institutes/grid.411982.7
191 schema:familyName Oh
192 schema:givenName Man Hwan
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136422063.84
194 rdf:type schema:Person
195 sg:person.012536711642.06 schema:affiliation N55c8b3e6f4c44217864880e5385dc117
196 schema:familyName Oh
197 schema:givenName Dong-yep
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012536711642.06
199 rdf:type schema:Person
200 sg:person.01276133560.77 schema:affiliation Nc4aa5458702147d9a1efaf9c2731d10e
201 schema:familyName Ha
202 schema:givenName Jaejung
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276133560.77
204 rdf:type schema:Person
205 sg:person.01333145216.07 schema:affiliation https://www.grid.ac/institutes/grid.411982.7
206 schema:familyName Han
207 schema:givenName Kyudong
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333145216.07
209 rdf:type schema:Person
210 sg:person.0721670212.07 schema:affiliation https://www.grid.ac/institutes/grid.411968.3
211 schema:familyName Nam
212 schema:givenName Insik
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721670212.07
214 rdf:type schema:Person
215 sg:pub.10.1007/s10528-009-9235-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019001734
216 https://doi.org/10.1007/s10528-009-9235-5
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/s11033-011-1190-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036446986
219 https://doi.org/10.1007/s11033-011-1190-7
220 rdf:type schema:CreativeWork
221 sg:pub.10.1186/1471-2156-9-33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015994257
222 https://doi.org/10.1186/1471-2156-9-33
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1006/abbi.2000.2153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006718533
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.livsci.2014.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005746949
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0378-1119(99)00357-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009699405
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1079/pns2003248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044780368
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1111/asj.12357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047094530
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1111/j.1365-2052.2007.01681.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047570134
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1111/j.1365-2052.2009.01940.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032415155
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1111/j.1365-2052.2011.02217.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051251723
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1152/physiolgenomics.00043.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027765042
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1159/000085672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031090778
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1359/jbmr.020605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020775227
245 rdf:type schema:CreativeWork
246 https://doi.org/10.2527/jas.2008-1427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070886700
247 rdf:type schema:CreativeWork
248 https://doi.org/10.2527/jas.2010-3121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070887472
249 rdf:type schema:CreativeWork
250 https://doi.org/10.2527/jas.2011-4753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070888208
251 rdf:type schema:CreativeWork
252 https://doi.org/10.5713/ajas.2007.466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073086573
253 rdf:type schema:CreativeWork
254 https://doi.org/10.5713/ajas.2009.80573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073087033
255 rdf:type schema:CreativeWork
256 https://doi.org/10.5713/ajas.2012.12078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039288554
257 rdf:type schema:CreativeWork
258 https://www.grid.ac/institutes/grid.258676.8 schema:alternateName Konkuk University
259 schema:name Department of Animal Science and Technology, Sanghuh College of Life Sciences, Konkuk University, 05029, Seoul, Republic of Korea
260 rdf:type schema:Organization
261 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
262 schema:name Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, 08826, Seoul, Republic of Korea
263 rdf:type schema:Organization
264 https://www.grid.ac/institutes/grid.411968.3 schema:alternateName Hankyong National University
265 schema:name Department of Biotechnology, College of Agriculture & Life Science, Hankyong National University, 17579, Anseong, Gyeonggi, Republic of Korea
266 Research Center for Environment Friendly and Quality Livestock Production Technology, Hankyong National University, 17579, Anseong, Gyeonggi, Republic of Korea
267 rdf:type schema:Organization
268 https://www.grid.ac/institutes/grid.411982.7 schema:alternateName Dankook University
269 schema:name BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, 31116, Cheonan, Republic of Korea
270 Department of Nanobiomedical Science, Dankook University, 31116, Cheonan, Republic of Korea
271 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...