Forensic and population genetic analyses of the GlobalFiler STR loci in the Mongolian population View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04

AUTHORS

Eun-Ji Choi, Ki-Won Park, Yang-Han Lee, Youn-Hyoung Nam, Ganbold Suren, Uyanga Ganbold, Ji-Ae Kim, So-Yeon Kim, Hye-Min Kim, Kicheol Kim, Wook Kim

ABSTRACT

We have analyzed 24 loci including autosomal and Y-chromosomal short tandem repeats (STRs), Y-indel, and sex-determining marker in a sample of 267 unrelated individuals from the Mongolian population using the GlobalFiler™ PCR Amplification Kit to provide an expanded and more reliable forensic database. Khalkh among 15 Mongolian minor-groups accounts for about 80% of the entire Mongolian population. A total of 267 different DNA profiles were found in this work. The highest gene diversity was observed in the SE33 (0.9376) locus, and the lowest value was found in the TPOX (0.6142) locus. Although individual power of discrimination estimates varied at the studied loci, combined probability of match from the 21 STR loci was estimated to be 1.139 × 10−24, which is highly informative. Based on the results of pairwise FST genetic distances and multi-dimensional scaling plot showed that Mongolians were clustered into Europeans and Asians, although Mongolia is geographically located in Northeastern Asia. Thus, the present survey of the Mongolian population may help establish a comprehensive reference database for forensic and population genetic analyses. More... »

PAGES

423-431

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13258-016-0511-6

DOI

http://dx.doi.org/10.1007/s13258-016-0511-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008173495


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