Applications of cell-based phage display panning to proteomic analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-02-28

AUTHORS

Kristine M. Kim, MinJeong Kang, Eugene C. Yi

ABSTRACT

In the post-genomic era, proteomics together with genomic tools have led to powerful new strategies in basic and clinical research. These combined “omics” technologies are being integrated into the drug target discovery process. Unlike the genome, the proteome is a highly dynamic entity that requires techniques capable of analyzing on selected populations of proteins in specific biological conditions that reflect the proteins’ functional characteristics. Antibodies have become one of the most important reagents for the analysis of selected populations of proteins, and the application of phage-display antibody libraries to high-throughput antibody generation against large numbers of various antigens provides a tool for proteome-wide protein expression analysis. In this review, we will discuss the utility of phage-display antibodies in proteomics applications, specifically for the discovery of novel disease markers and therapeutic targets. More... »

PAGES

9-15

References to SciGraph publications

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  • 1990-12. Phage antibodies: filamentous phage displaying antibody variable domains in NATURE
  • 2007-02-27. Ribosome display: selecting and evolving proteins in vitro that specifically bind to a target in NATURE METHODS
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13258-010-0150-2

    DOI

    http://dx.doi.org/10.1007/s13258-010-0150-2

    DIMENSIONS

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