153Sm-HM for arthritic knee pain. Estimated dosimetry View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-01-12

AUTHORS

Alberto E. Hardy-Pérez, Eugenio Torres-García, Consuelo Arteaga-de-Murphy, Martha Pedraza-López, Eleni Mitsoura, Nallely P. Jiménez-Mancilla

ABSTRACT

Osteoarthritis is the most common type of arthropathy and after cardiovascular diseases is the most disabling disease in developing countries. The dosimetry for the clinical application of 153-samarium-hydroxymacroaggregates (153Sm-HM) for radiation synovectomy (RSV) and palliative treatment for arthritic pain, as far as we know, has not been reported. The aim of this research was to estimate the radiation dose necessary for synovial ablation and pain palliation with minimum risk to the patient. 153Sm-HM (370 MBq) was administered intra-articularly in a patient with severe knee pain and hindered motility. Regions of interest drawn on sequential, conjugated, anterior and posterior scintigraphy images were used to obtain the respective activity. The data was entered into a knee joint histological-geometric model designed with micrometric dimensions to represent the synovial cell layers. The Monte Carlo code was used to calculate the absorbed dose in each of the 12 model-cells representing the distance from the synovial liquid to the cartilage or bone. The absorbed dose in the synovial cavity was 114 Gy which is sufficient energy for RSV. The treated patient referred little pain and higher motility with no adverse reactions. 153Sm-HM is a potentially valid radiopharmaceutical for RSV, which effectively palliates knee pain. More... »

PAGES

63-69

References to SciGraph publications

  • 1995-09. Beta-particle dosimetry in radiation synovectomy in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1997-08. 153Sm metallic-hydroxide macroaggregates: An improved preparation for radiation synovectomy in JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • 1995-09. A survey of radiation synovectomy in Europe, 1991–1993 in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2004-12-14. Clinical efficacy of radiation synovectomy in digital joint osteoarthritis in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1993-11. Radiation synovectomy revisited in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2003-08-15. NOREC, a Monte Carlo code for simulating electron tracks in liquid water in RADIATION AND ENVIRONMENTAL BIOPHYSICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13246-011-0122-0

    DOI

    http://dx.doi.org/10.1007/s13246-011-0122-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039495700

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22238018


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