Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-04

AUTHORS

Chen Ling, Zunpeng Liu, Moshi Song, Weiqi Zhang, Si Wang, Xiaoqian Liu, Shuai Ma, Shuhui Sun, Lina Fu, Qun Chu, Juan Carlos Izpisua Belmonte, Zhaoxia Wang, Jing Qu, Yun Yuan, Guang-Hui Liu

ABSTRACT

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary cerebrovascular disease caused by a NOTCH3 mutation. However, the underlying cellular and molecular mechanisms remain unidentified. Here, we generated non-integrative induced pluripotent stem cells (iPSCs) from fibroblasts of a CADASIL patient harboring a heterozygous NOTCH3 mutation (c.3226C>T, p.R1076C). Vascular smooth muscle cells (VSMCs) differentiated from CADASIL-specific iPSCs showed gene expression changes associated with disease phenotypes, including activation of the NOTCH and NF-κB signaling pathway, cytoskeleton disorganization, and excessive cell proliferation. In comparison, these abnormalities were not observed in vascular endothelial cells (VECs) derived from the patient's iPSCs. Importantly, the abnormal upregulation of NF-κB target genes in CADASIL VSMCs was diminished by a NOTCH pathway inhibitor, providing a potential therapeutic strategy for CADASIL. Overall, using this iPSC-based disease model, our study identified clues for studying the pathogenic mechanisms of CADASIL and developing treatment strategies for this disease. More... »

PAGES

249-271

References to SciGraph publications

  • 2012-09. The Notch signalling system: recent insights into the complexity of a conserved pathway in NATURE REVIEWS GENETICS
  • 2016-03. Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs in PROTEIN & CELL
  • 2008-03. Thrombospondins: from structure to therapeutics in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2018-12. p73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton in CELL DEATH & DISEASE
  • 2017-05. CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs in PROTEIN & CELL
  • 2013-06. Diabetes Mellitus and Inflammation in CURRENT DIABETES REPORTS
  • 2018-12. ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells in CELL DISCOVERY
  • 1996-10. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia in NATURE
  • 2018-12. Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis in NATURE COMMUNICATIONS
  • 2018-11. CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells in PROTEIN & CELL
  • 2012-11. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2 in NATURE
  • 2015. Characterizing the DNA Binding Site Specificity of NF-κB with Protein-Binding Microarrays (PBMs) in NF-KAPPA B
  • 2014-05. Therapeutic modulation of Notch signalling — are we there yet? in NATURE REVIEWS DRUG DISCOVERY
  • 2011-10. Intracranial aneurysms: from vessel wall pathology to therapeutic approach in NATURE REVIEWS NEUROLOGY
  • 2016-11. Notch signalling in context in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2014-12. Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs in NATURE COMMUNICATIONS
  • 2014-12. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2016-03-03. Mechanism of intermediate filament recognition by plakin repeat domains revealed by envoplakin targeting of vimentin in NATURE COMMUNICATIONS
  • 2015-04. HISAT: a fast spliced aligner with low memory requirements in NATURE METHODS
  • 2011-05. A more efficient method to generate integration-free human iPS cells in NATURE METHODS
  • 2018-04. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome in PROTEIN & CELL
  • 2017-12. STAT3 and NF-κB are Simultaneously Suppressed in Dendritic Cells in Lung Cancer in SCIENTIFIC REPORTS
  • 2009-11. Notch3 signaling promotes the development of pulmonary arterial hypertension in NATURE MEDICINE
  • 2011-12. Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs in CELL RESEARCH
  • 2016-08-04. Looking to the future following 10 years of induced pluripotent stem cell technologies in NATURE PROTOCOLS
  • 2019-04. Redistribution of Mature Smooth Muscle Markers in Brain Arteries in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy in TRANSLATIONAL STROKE RESEARCH
  • 2015-04. The Small Leucine-Rich Proteoglycan BGN Accumulates in CADASIL and Binds to NOTCH3 in TRANSLATIONAL STROKE RESEARCH
  • 2017-09. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding in CELL RESEARCH
  • 2017-12. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects in BMC MEDICINE
  • 2010-01. Cell mechanics and the cytoskeleton in NATURE
  • 2018-08-01. Chemical screen identifies a geroprotective role of quercetin in premature aging in PROTEIN & CELL
  • 2011-04. Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome in NATURE
  • 2015-08. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells in NATURE CELL BIOLOGY
  • 2015-12. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype in NATURE COMMUNICATIONS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13238-019-0608-1

    DOI

    http://dx.doi.org/10.1007/s13238-019-0608-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112213048

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30778920


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