Aneuploidy in pluripotent stem cells and implications for cancerous transformation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-08

AUTHORS

Jie Na, Duncan Baker, Jing Zhang, Peter W. Andrews, Ivana Barbaric

ABSTRACT

Owing to a unique set of attributes, human pluripotent stem cells (hPSCs) have emerged as a promising cell source for regenerative medicine, disease modeling and drug discovery. Assurance of genetic stability over long term maintenance of hPSCs is pivotal in this endeavor, but hPSCs can adapt to life in culture by acquiring non-random genetic changes that render them more robust and easier to grow. In separate studies between 12.5% and 34% of hPSC lines were found to acquire chromosome abnormalities over time, with the incidence increasing with passage number. The predominant genetic changes found in hPSC lines involve changes in chromosome number and structure (particularly of chromosomes 1, 12, 17 and 20), reminiscent of the changes observed in cancer cells. In this review, we summarize current knowledge on the causes and consequences of aneuploidy in hPSCs and highlight the potential links with genetic changes observed in human cancers and early embryos. We point to the need for comprehensive characterization of mechanisms underpinning both the acquisition of chromosomal abnormalities and selection pressures, which allow mutations to persist in hPSC cultures. Elucidation of these mechanisms will help to design culture conditions that minimize the appearance of aneuploid hPSCs. Moreover, aneuploidy in hPSCs may provide a unique platform to analyse the driving forces behind the genome evolution that may eventually lead to cancerous transformation. More... »

PAGES

569-579

References to SciGraph publications

  • 2009-05. Chromosome instability is common in human cleavage-stage embryos in NATURE MEDICINE
  • 2004-04. Karyotype of human ES cells during extended culture in NATURE BIOTECHNOLOGY
  • 2006-03. Chromosomal integrity maintained in five human embryonic stem cell lines after prolonged in vitro culture in CHROMOSOME RESEARCH
  • 2007-02. Adaptation to culture of human embryonic stem cells and oncogenesis in vivo in NATURE BIOTECHNOLOGY
  • 2011-04. Karyotypic abnormalities in human induced pluripotent stem cells and embryonic stem cells in NATURE BIOTECHNOLOGY
  • 1973-06. A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining in NATURE
  • 2002-12. BMP4 initiates human embryonic stem cell differentiation to trophoblast in NATURE BIOTECHNOLOGY
  • 2009-03. The anti-apoptotic gene survivin contributes to teratoma formation by human embryonic stem cells in NATURE BIOTECHNOLOGY
  • 2011-12. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage in NATURE BIOTECHNOLOGY
  • 2008-12. Human embryonic stem cells reveal recurrent genomic instability at 20q11.21 in NATURE BIOTECHNOLOGY
  • 2006-03. CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells in NATURE BIOTECHNOLOGY
  • 2013-09. The origin and impact of embryonic aneuploidy in HUMAN GENETICS
  • 2012-01-18. DNA breaks and chromosome pulverization from errors in mitosis in NATURE
  • 2009-07. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2003-05. Role of ERas in promoting tumour-like properties in mouse embryonic stem cells in NATURE
  • 2013-09. Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2005-10. Genomic alterations in cultured human embryonic stem cells in NATURE GENETICS
  • 2004-01. Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells in NATURE BIOTECHNOLOGY
  • 2005-01. Preserving the genetic integrity of human embryonic stem cells in NATURE BIOTECHNOLOGY
  • 2003-10. 12p-Amplicon structure analysis in testicular germ cell tumors of adolescents and adults by array CGH in ONCOGENE
  • 2013-10. The cancer biology of whole-chromosome instability in ONCOGENE
  • 2009-01. Characterization of human embryonic stem cells with features of neoplastic progression in NATURE BIOTECHNOLOGY
  • 2010-11. High Resolution Array-CGH Characterization of Human Stem Cells Using a Stem Cell Focused Microarray in MOLECULAR BIOTECHNOLOGY
  • 2008-12. Recurrent chromosomal abnormalities in human embryonic stem cells in NATURE BIOTECHNOLOGY
  • 2007-05. The spindle-assembly checkpoint in space and time in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1982-12. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia in NATURE
  • 2010-04. High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity in NATURE BIOTECHNOLOGY
  • 2001-04. To err (meiotically) is human: the genesis of human aneuploidy in NATURE REVIEWS GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13238-014-0073-9

    DOI

    http://dx.doi.org/10.1007/s13238-014-0073-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029331454

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24899134


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