EZH2, an epigenetic driver of prostate cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-05

AUTHORS

Yeqing Angela Yang, Jindan Yu

ABSTRACT

The histone methyltransferase EZH2 has been in the limelight of the field of cancer epigenetics for a decade now since it was first discovered to exhibit an elevated expression in metastatic prostate cancer. It persists to attract much scientific attention due to its important role in the process of cancer development and its potential of being an effective therapeutic target. Thus here we review the dysregulation of EZH2 in prostate cancer, its function, upstream regulators, downstream effectors, and current status of EZH2-targeting approaches. This review therefore provides a comprehensive overview of EZH2 in the context of prostate cancer. More... »

PAGES

331-341

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13238-013-2093-2

    DOI

    http://dx.doi.org/10.1007/s13238-013-2093-2

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23636686


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