Hippo pathway in intestinal homeostasis and tumorigenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-04-10

AUTHORS

Lanfen Chen, Funiu Qin, Xianming Deng, Joseph Avruch, Dawang Zhou

ABSTRACT

The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell death. Recent findings implicate that this pathway is involved in the process of intestinal regeneration and tumorigenesis. Here we summarize current studies for the function of the Hippo signaling pathway in intestinal homeostasis, regeneration and tumorigenesis, and the crosstalk between the Hippo signaling pathway and other major signaling pathways, i.e. Wnt, Notch and Jak/Stat signaling pathways in intestinal compartment. More... »

PAGES

305-310

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13238-012-2913-9

DOI

http://dx.doi.org/10.1007/s13238-012-2913-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027882016

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22492181


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