The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03

AUTHORS

Sunil K. Verma, Trivadi S. Ganesan, Uday Kishore, Peter J. Parker

ABSTRACT

Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior. More... »

PAGES

237-249

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13238-011-1028-z

    DOI

    http://dx.doi.org/10.1007/s13238-011-1028-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047120167

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21468893


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