A loop matters for FTO substrate selection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-07

AUTHORS

Zhifu Han, Ning Huang, Tianhui Niu, Jijie Chai

ABSTRACT

Recent studies have unequivocally established the link between FTO and obesity. FTO was biochemically shown to belong to the AlkB-like family DNA/RNA demethylase. However, FTO differs from other AlkB members in that it has unique substrate specificity and contains an extended C-terminus with unknown functions. Insight into the substrate selection mechanism and a functional clue to the C-terminus of FTO were gained from recent structural and biochemical studies. These data would be valuable to design FTO-specific inhibitors that can be potentially translated into therapeutic agents for treatment of obesity or obesity-related diseases. More... »

PAGES

616-620

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13238-010-0082-2

DOI

http://dx.doi.org/10.1007/s13238-010-0082-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049377049

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21203933


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