Clinical Profile of Scrub Typhus in Pregnancy in Sub-Himalayan Region View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10-16

AUTHORS

Ritesh Kumar, Surinder Thakur, Rajesh Bhawani, Anil Kanga, Asha Ranjan

ABSTRACT

Background Scrub typhus is rare in pregnancy, but it has now become an important cause of febrile illness in pregnancy in sub-Himalayan region of India. Only a few case reports have been published so far, and they show adverse maternal and fetal outcomes. No consensus has been reached till now regarding treatment.MethodologyAll the pregnant patients irrespective of period of gestation admitted with febrile illness with positive IgM ELISA for scrub typhus with or without eschar were included. The clinical profile was observed using a detailed history of symptoms, travel, recreation, agricultural activities, treatment record prior to admission, and a detailed examination, and the treatment outcome was noted. Fever workup including cultures, CXR, CSF analysis, serology for scrub was done. IgM scrub typhus was done by kit method manufactured by InBios Intertational, Inc.ResultsWe observed in total 14 pregnant patients out of which eight were in the the second trimester and six were in the third trimester. The clinical features of the disease observed for pregnant females were the same as for nonpregnant females. There was no difference in the severity of scrub typhus between pregnant and nonpregnant women. No mortality was found in these patients. On follow-up, they had normal peripartum and postpartum periods. All were treated with azithromycin 500 mg once a day for 5 days.Conclusion Although rare, scrub typhus should be considered in differential diagnosis of fever in pregnant patients especially in scrub season. Azithromycin should be the drug of choice in pregnancy as it has no adverse effect on fetus and pregnancy outcome. More... »

PAGES

82-87

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13224-015-0776-8

DOI

http://dx.doi.org/10.1007/s13224-015-0776-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022160133

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27651583


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