Tobacco habituated and non-habituated subjects exhibit different mutational spectrums in head and neck squamous cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10

AUTHORS

Rakesh M. Rawal, Madhvi N. Joshi, Poonam Bhargava, Inayat Shaikh, Aanal S. Pandit, Riddhi P. Patel, Shanaya Patel, Kiran Kothari, Manoj Shah, Akshay Saxena, Snehal B. Bagatharia

ABSTRACT

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common non-skin cancer in the world. Tobacco chewing is implicated with most of the cases of HNSCC but this type of cancer is increasing in non-tobacco chewers as well. This study was instigated to provide comprehensive variant and gene-level data in HNSCC subjects of the Indian population and fill the gap in the literature on comparative assessment of gene mutations in cancer subjects with a habit of tobacco and those without any habit using targeted amplicon sequencing. We performed targeted Amplicon sequencing of 409 tumor suppressor genes and oncogenes, frequently mutated across many cancer types, including head and neck. DNA from primary tumor tissues and matched blood was analyzed for HNSCC patients with a habit of tobacco and those without any habit. PDE4DIP, SYNE1, and NOTCH1 emerged as the highly mutated genes in HNSCC. A total of 39 candidate causal variants in 22 unique cancer driver genes were identified in non-habitual (WoH) and habitual (WH) subjects. Comparison of genes from both the subjects, showed seven unique cancer driver genes (KIT, ATM, RNF213, GATA2, DST, RET, CYP2C19) in WoH, while WH showed five (IL7R, PKHD1, MLL3, PTPRD, MAPK8) and 10 genes (SETD2, ATR, CDKN2A, NCOA4, TP53, SYNE1, KAT6B, THBS1, PTPRT, and FGFR3) were common to both subjects. In addition to this NOTCH1, NOTCH2, and NOTCH4 gene were found to be mutated only in habitual subjects. These findings strongly support a causal role for tobacco, acting via PI3K and MAPK pathway inhibition and stimulation of various genes leading to oncogenic transformations in case of tobacco chewers. In case of non-tobacco chewers it appears that mutations in the pathway affecting the squamous epithelial lineage and DNA repair genes lead to HNSCC. Somatic mutation in CYP2C19 gene in the non-habitual subjects suggests that this gene may have a tobacco independent role in development and progression of HNSCC. In addition to sharing high mutation rate, NOTCH gene family was found to be mutated only in habitual sample. Further, presence of mutated genes not earlier reported to be involved in HNSCC, suggest that the Indian sub-continent may have different sets of genes, as compared to other parts of the world, involved in the development and progression of HNSCC. More... »

PAGES

685-696

References to SciGraph publications

  • 2004-07. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website in BRITISH JOURNAL OF CANCER
  • 2012-12. Steps to ensure accuracy in genotype and SNP calling from Illumina sequencing data in BMC GENOMICS
  • 2011-08. Rare variants in the ATMgene and risk of breast cancer in BREAST CANCER RESEARCH
  • 2006-03. Cytochrome P450 pharmacogenetics and cancer in ONCOGENE
  • 2012-12. Expression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2012-07. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators in NATURE GENETICS
  • 2013-12. Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma in GENOME MEDICINE
  • 2008-10-23. Comprehensive genomic characterization defines human glioblastoma genes and core pathways in NATURE
  • 2011-02. Asymmetric cell divisions promote Notch-dependent epidermal differentiation in NATURE
  • 2003-11. Effects of alcohol and tobacco on aerodigestive cancer risks: a meta-regression analysis in CANCER CAUSES & CONTROL
  • 2002-08. GATA-1 and GATA-2 gene expression is related to the severity of dysplasia in myelodysplastic syndrome in LEUKEMIA
  • 2012-05. Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes in NATURE GENETICS
  • 2011-10. Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia in NATURE GENETICS
  • 2012-12. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia in NATURE GENETICS
  • Journal

    TITLE

    3 Biotech

    ISSUE

    5

    VOLUME

    5

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13205-014-0267-0

    DOI

    http://dx.doi.org/10.1007/s13205-014-0267-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025654113

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28324520


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