pH-sensitive bovine serum albumin nanoparticles for paclitaxel delivery and controlled release to cervical cancer View Full Text


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Article Info

DATE

2022-09-24

AUTHORS

Chunyan Zheng, Li Wang, Chunfang Gao

ABSTRACT

In this study, by altering bovine serum albumin (BSA), we were able to create a regulated drug release through a stimulus sensitive mechanism. Paclitaxel (PTX) loaded BSA nanoparticles (NPs) were created using the desolvation method, and after being cross-linked using Schiff base bonds, they became a PTX loaded pH sensitive system (PTX@BSA-NPs). The synthesised PTX@BSA-NPs displayed wide polydispersity + 26 mV, a large negative surface charge, a particle size of about 150 nm, and a high drug loading capacity (22.2%). Size variation and charge reversal showed the pH sensitivity of PTX@BSA-NPs after incubation at various pH levels. In the in vitro drug release study, the disintegration of NPs brought on by Schiff base bond cleavage clearly increased the release of PTX. A thorough investigation of the drug release mechanism using a semi-empirical model confirmed that pH played a crucial role in the release of drugs when under rigorous control. The cytotoxicity test showed that PTX@ BSANPs significantly outperformed the free PTX control in terms of their ability to kill cervical cancer cells (HeLa). Therefore, these results indicated that PTX@BSA-NPs might be helpful for medication distribution in the treatment of cancer and for controlled release. This study also showed that it may be a wise choice to modify commercial biomaterials to create stimuli-responsive drug delivery systems to create nanomedicine with many functions. More... »

PAGES

1-11

References to SciGraph publications

  • 2019-01-29. Nanoparticle administration method in cell culture alters particle-cell interaction in SCIENTIFIC REPORTS
  • 2020-05-14. Engineering nanoparticles to reprogram radiotherapy and immunotherapy: recent advances and future challenges in JOURNAL OF NANOBIOTECHNOLOGY
  • 2013-07-20. Cisplatin-functionalized silica nanoparticles for cancer chemotherapy in CANCER NANOTECHNOLOGY
  • 2018-11-26. Understanding flow dynamics, viability and metastatic potency of cervical cancer (HeLa) cells through constricted microchannel in SCIENTIFIC REPORTS
  • 2021-11-24. Toxicology of Nanoparticles in Drug Delivery in CURRENT PATHOBIOLOGY REPORTS
  • 2021-01-12. New combination chemotherapy of cisplatin with an electron-donating compound for treatment of multiple cancers in SCIENTIFIC REPORTS
  • 2019-03-04. Biotin-modified bovine serum albumin nanoparticles as a potential drug delivery system for paclitaxel in JOURNAL OF MATERIALS SCIENCE
  • 2021-10-09. Preparation and characterization of BSA as a model protein loaded chitosan nanoparticles for the development of protein-/peptide-based drug delivery system in FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES
  • 2021-05-05. Enhancement of doxorubicin anti-cancer activity by vascular targeting using IsoDGR/cytokine-coated nanogold in JOURNAL OF NANOBIOTECHNOLOGY
  • 2017-10-06. Novel biomaterial strategies for controlled growth factor delivery for biomedical applications in NPG ASIA MATERIALS
  • 2018-09-19. Nano based drug delivery systems: recent developments and future prospects in JOURNAL OF NANOBIOTECHNOLOGY
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    http://scigraph.springernature.com/pub.10.1007/s13204-022-02635-y

    DOI

    http://dx.doi.org/10.1007/s13204-022-02635-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1151304947


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