Essai clinique randomisé comparant l’efficacité et la tolérance de la combinaison artémisinine-naphthoquine (Arco®) et artéméther-luméfantrine (Coartem®) dans le traitement du ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-08

AUTHORS

D. Kinde-Gazard, A. Ogouyèmi-Hounto, L. Capo-Chichi, J. Gbaguidi, A. Massougbodji

ABSTRACT

The Ministry of Health recommended in Benin, since 2004, artemisinin-based combination, artemether-lumtefantrine (Coartem®), therapy for the treatment of uncomplicated malaria. To resolve the difficulties related to observance, we are interested in a new combination, artemisinin-naphthoquine (Arco®). A study was conducted to assess and compare the efficacy and tolerability of the fixed combination artemisinin (125 mg)-naphthoquine (50 mg), a single-dose drug, administered one day versus artemether (20 mg)-lumefantrine (120 mg).The clinical assessment was a single-blinded, two-arm, randomized trial comparing Arco® combination as a single-dose regimen and three-day regimen of Coartem® for the treatment of uncomplicated falciparum malaria, from july to october 2008 and may to september 2009, with 28 days of follow-up in children. PCR genotyping was used to classify re-infection or recrudescence. The primary outcome measures for efficacy were cure rates on days 3, 7, 14, 21 and 28. Secondary outcomes included parasite clearance time and fever clearance time. The main outcome measures for safety were incidences of post-treatment clinical and laboratory adverse events. A total of 174 patients (84 in Arco® group and 90 in Coartem® group) were evaluated for clinical and parasitological outcomes. The cure rate was 98.8% for Arco® and 100% for Coartem® on day 28, with no statistically significant difference. Fever clearance was obtained within 24 hours in both groups. The parasite clearance is obtained at 48 hours in Arco® group and at 60 hours in Coartem® group. Both treatments were well tolerated without major side effects. This study therefore concluded that the combination of artemisinin-naphthoquine is as effective and well tolerated as the combination artemether-lumefantrine in the treatment of uncomplicated malaria in Benin children. This medication administered in single dose is therapy of choice to reduce compliance problems during malaria treatment and also to facilitate community-based care of malaria. More... »

PAGES

208-214

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13149-012-0211-7

DOI

http://dx.doi.org/10.1007/s13149-012-0211-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052683693

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22328063


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antimalarials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Artemisinins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Administration Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Combinations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ethanolamines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Malaria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Naphthoquinones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Single-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Kinde-Gazard", 
        "givenName": "D.", 
        "id": "sg:person.01163337724.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163337724.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "06 BP 1372, Cotonou, B\u00e9nin"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ogouy\u00e8mi-Hounto", 
        "givenName": "A.", 
        "id": "sg:person.01052433001.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052433001.57"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Capo-Chichi", 
        "givenName": "L.", 
        "type": "Person"
      }, 
      {
        "familyName": "Gbaguidi", 
        "givenName": "J.", 
        "type": "Person"
      }, 
      {
        "familyName": "Massougbodji", 
        "givenName": "A.", 
        "id": "sg:person.01063422436.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063422436.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1475-2875-8-148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012714673", 
          "https://doi.org/10.1186/1475-2875-8-148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-7-106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014915280", 
          "https://doi.org/10.1186/1475-2875-7-106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2003.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015840911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.b2763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016533575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-8-196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017310659", 
          "https://doi.org/10.1186/1475-2875-8-196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-4-46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022561567", 
          "https://doi.org/10.1186/1475-2875-4-46"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2010.09-0265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033030250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2009.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033573385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2007.01859.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036389143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2007.01859.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036389143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-3305-3-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042458629", 
          "https://doi.org/10.1186/1756-3305-3-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ph3123581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042982410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pctr.0020020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049650617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trstmh.2004.09.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054751024"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-08", 
    "datePublishedReg": "2012-08-01", 
    "description": "The Ministry of Health recommended in Benin, since 2004, artemisinin-based combination, artemether-lumtefantrine (Coartem\u00ae), therapy for the treatment of uncomplicated malaria. To resolve the difficulties related to observance, we are interested in a new combination, artemisinin-naphthoquine (Arco\u00ae). A study was conducted to assess and compare the efficacy and tolerability of the fixed combination artemisinin (125 mg)-naphthoquine (50 mg), a single-dose drug, administered one day versus artemether (20 mg)-lumefantrine (120 mg).The clinical assessment was a single-blinded, two-arm, randomized trial comparing Arco\u00ae combination as a single-dose regimen and three-day regimen of Coartem\u00ae for the treatment of uncomplicated falciparum malaria, from july to october 2008 and may to september 2009, with 28 days of follow-up in children. PCR genotyping was used to classify re-infection or recrudescence. The primary outcome measures for efficacy were cure rates on days 3, 7, 14, 21 and 28. Secondary outcomes included parasite clearance time and fever clearance time. The main outcome measures for safety were incidences of post-treatment clinical and laboratory adverse events. A total of 174 patients (84 in Arco\u00ae group and 90 in Coartem\u00ae group) were evaluated for clinical and parasitological outcomes. The cure rate was 98.8% for Arco\u00ae and 100% for Coartem\u00ae on day 28, with no statistically significant difference. Fever clearance was obtained within 24 hours in both groups. The parasite clearance is obtained at 48 hours in Arco\u00ae group and at 60 hours in Coartem\u00ae group. Both treatments were well tolerated without major side effects. This study therefore concluded that the combination of artemisinin-naphthoquine is as effective and well tolerated as the combination artemether-lumefantrine in the treatment of uncomplicated malaria in Benin children. This medication administered in single dose is therapy of choice to reduce compliance problems during malaria treatment and also to facilitate community-based care of malaria.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s13149-012-0211-7", 
    "inLanguage": [
      "fr"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1082087", 
        "issn": [
          "0037-9085", 
          "1961-9049"
        ], 
        "name": "Bulletin de la Soci\u00e9t\u00e9 de pathologie exotique", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "105"
      }
    ], 
    "name": "Essai clinique randomis\u00e9 comparant l\u2019efficacit\u00e9 et la tol\u00e9rance de la combinaison art\u00e9misinine-naphthoquine (Arco\u00ae) et art\u00e9m\u00e9ther-lum\u00e9fantrine (Coartem\u00ae) dans le traitement du paludisme simple au B\u00e9nin", 
    "pagination": "208-214", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "faf2d9f74301ef73e7e3aa757a0e2ed20ebb05efdf132a67f3280a32342f614e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22328063"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9212564"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13149-012-0211-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052683693"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13149-012-0211-7", 
      "https://app.dimensions.ai/details/publication/pub.1052683693"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000524.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs13149-012-0211-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13149-012-0211-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13149-012-0211-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13149-012-0211-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13149-012-0211-7'


 

This table displays all metadata directly associated to this object as RDF triples.

206 TRIPLES      21 PREDICATES      60 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13149-012-0211-7 schema:about N272d959c14a745b2bbc1a721a9c0ffe7
2 N2f55355e930941d1ad7154f714a6d600
3 N38bddc1551a742fc89ebe280da4f2c36
4 N42332e637dea4f3fab5477e9f0fd705e
5 N498949b8e8414183a77065ddc31fecb1
6 N517c6269f800434b8a6fbf671e34180f
7 N926875a54c3f4739829b6dce879b23d3
8 N951b741156b843c7a0bf76e0827b16bf
9 N9a871b000d01410e9b9d736661dc2c1c
10 Na23e9f08e3d34b4d95fb770542d62dba
11 Na74c306a8251405aaf577a4fbf7d9d02
12 Nab0f76fbf7834864b2101faa68bfd7c2
13 Nad4581fde9c34bc3bfb73e0a4e94ed76
14 Nb5f25c34bf114fa1a6b00b7a08b1825c
15 Nc934b8bc88864c9fa0e64f7c7bd802a5
16 Ne005ea3debc4444ba77c3e17be0f79a4
17 Ne7c4828d401545ceb701fb419e10abd2
18 Nf8e9528d4b404717ae8601407ce97e30
19 anzsrc-for:11
20 anzsrc-for:1103
21 schema:author N1c6bc2a2ca17446ea5d35191f607fe33
22 schema:citation sg:pub.10.1186/1475-2875-4-46
23 sg:pub.10.1186/1475-2875-7-106
24 sg:pub.10.1186/1475-2875-8-148
25 sg:pub.10.1186/1475-2875-8-196
26 sg:pub.10.1186/1756-3305-3-1
27 https://doi.org/10.1016/j.actatropica.2003.11.008
28 https://doi.org/10.1016/j.actatropica.2009.05.007
29 https://doi.org/10.1016/j.trstmh.2004.09.013
30 https://doi.org/10.1111/j.1365-3156.2007.01859.x
31 https://doi.org/10.1136/bmj.b2763
32 https://doi.org/10.1371/journal.pctr.0020020
33 https://doi.org/10.3390/ph3123581
34 https://doi.org/10.4269/ajtmh.2010.09-0265
35 schema:datePublished 2012-08
36 schema:datePublishedReg 2012-08-01
37 schema:description The Ministry of Health recommended in Benin, since 2004, artemisinin-based combination, artemether-lumtefantrine (Coartem®), therapy for the treatment of uncomplicated malaria. To resolve the difficulties related to observance, we are interested in a new combination, artemisinin-naphthoquine (Arco®). A study was conducted to assess and compare the efficacy and tolerability of the fixed combination artemisinin (125 mg)-naphthoquine (50 mg), a single-dose drug, administered one day versus artemether (20 mg)-lumefantrine (120 mg).The clinical assessment was a single-blinded, two-arm, randomized trial comparing Arco® combination as a single-dose regimen and three-day regimen of Coartem® for the treatment of uncomplicated falciparum malaria, from july to october 2008 and may to september 2009, with 28 days of follow-up in children. PCR genotyping was used to classify re-infection or recrudescence. The primary outcome measures for efficacy were cure rates on days 3, 7, 14, 21 and 28. Secondary outcomes included parasite clearance time and fever clearance time. The main outcome measures for safety were incidences of post-treatment clinical and laboratory adverse events. A total of 174 patients (84 in Arco® group and 90 in Coartem® group) were evaluated for clinical and parasitological outcomes. The cure rate was 98.8% for Arco® and 100% for Coartem® on day 28, with no statistically significant difference. Fever clearance was obtained within 24 hours in both groups. The parasite clearance is obtained at 48 hours in Arco® group and at 60 hours in Coartem® group. Both treatments were well tolerated without major side effects. This study therefore concluded that the combination of artemisinin-naphthoquine is as effective and well tolerated as the combination artemether-lumefantrine in the treatment of uncomplicated malaria in Benin children. This medication administered in single dose is therapy of choice to reduce compliance problems during malaria treatment and also to facilitate community-based care of malaria.
38 schema:genre research_article
39 schema:inLanguage fr
40 schema:isAccessibleForFree false
41 schema:isPartOf N3e79ff28932048b793d2be87ae32312e
42 Na6cb164c30044e21b538d7350c4c77da
43 sg:journal.1082087
44 schema:name Essai clinique randomisé comparant l’efficacité et la tolérance de la combinaison artémisinine-naphthoquine (Arco®) et artéméther-luméfantrine (Coartem®) dans le traitement du paludisme simple au Bénin
45 schema:pagination 208-214
46 schema:productId N1fb4de93661940ed92b5ec4b1cf6a76a
47 N2f3234fb145e484498dda9f9a06ebcd7
48 N9462fff982f84b81891c48ea090a3454
49 Na73780572a764757bf0f84977119c6a7
50 Ncbdf48b1363d475180fba13c188674dc
51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052683693
52 https://doi.org/10.1007/s13149-012-0211-7
53 schema:sdDatePublished 2019-04-10T23:27
54 schema:sdLicense https://scigraph.springernature.com/explorer/license/
55 schema:sdPublisher Nc51bd00f70954681a3d44f16c9561590
56 schema:url http://link.springer.com/10.1007%2Fs13149-012-0211-7
57 sgo:license sg:explorer/license/
58 sgo:sdDataset articles
59 rdf:type schema:ScholarlyArticle
60 N1c6bc2a2ca17446ea5d35191f607fe33 rdf:first sg:person.01163337724.84
61 rdf:rest Nd9e6f75c39644c76ad1f806d77beaf6c
62 N1fb4de93661940ed92b5ec4b1cf6a76a schema:name doi
63 schema:value 10.1007/s13149-012-0211-7
64 rdf:type schema:PropertyValue
65 N272d959c14a745b2bbc1a721a9c0ffe7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Benin
67 rdf:type schema:DefinedTerm
68 N2f3234fb145e484498dda9f9a06ebcd7 schema:name nlm_unique_id
69 schema:value 9212564
70 rdf:type schema:PropertyValue
71 N2f55355e930941d1ad7154f714a6d600 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Adolescent
73 rdf:type schema:DefinedTerm
74 N38bddc1551a742fc89ebe280da4f2c36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Child
76 rdf:type schema:DefinedTerm
77 N3a3e29d931704e8782986bde6e4a58bd rdf:first sg:person.01063422436.58
78 rdf:rest rdf:nil
79 N3e79ff28932048b793d2be87ae32312e schema:issueNumber 3
80 rdf:type schema:PublicationIssue
81 N42332e637dea4f3fab5477e9f0fd705e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Infant
83 rdf:type schema:DefinedTerm
84 N498949b8e8414183a77065ddc31fecb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Malaria
86 rdf:type schema:DefinedTerm
87 N517c6269f800434b8a6fbf671e34180f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Male
89 rdf:type schema:DefinedTerm
90 N52b9ba8627284484bdc1b79df6c0a739 schema:name 06 BP 1372, Cotonou, Bénin
91 rdf:type schema:Organization
92 N7312587a185f4ba192523772b5e63ed5 rdf:first Nbadde4b53f49421894456e1277cc2e96
93 rdf:rest N3a3e29d931704e8782986bde6e4a58bd
94 N926875a54c3f4739829b6dce879b23d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Treatment Outcome
96 rdf:type schema:DefinedTerm
97 N9462fff982f84b81891c48ea090a3454 schema:name pubmed_id
98 schema:value 22328063
99 rdf:type schema:PropertyValue
100 N951b741156b843c7a0bf76e0827b16bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Female
102 rdf:type schema:DefinedTerm
103 N9a871b000d01410e9b9d736661dc2c1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Drug Combinations
105 rdf:type schema:DefinedTerm
106 Na23e9f08e3d34b4d95fb770542d62dba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Antimalarials
108 rdf:type schema:DefinedTerm
109 Na6cb164c30044e21b538d7350c4c77da schema:volumeNumber 105
110 rdf:type schema:PublicationVolume
111 Na73780572a764757bf0f84977119c6a7 schema:name readcube_id
112 schema:value faf2d9f74301ef73e7e3aa757a0e2ed20ebb05efdf132a67f3280a32342f614e
113 rdf:type schema:PropertyValue
114 Na74c306a8251405aaf577a4fbf7d9d02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Single-Blind Method
116 rdf:type schema:DefinedTerm
117 Nab0f76fbf7834864b2101faa68bfd7c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Naphthoquinones
119 rdf:type schema:DefinedTerm
120 Nad4581fde9c34bc3bfb73e0a4e94ed76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Child, Preschool
122 rdf:type schema:DefinedTerm
123 Nb5f25c34bf114fa1a6b00b7a08b1825c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Humans
125 rdf:type schema:DefinedTerm
126 Nbadde4b53f49421894456e1277cc2e96 schema:familyName Gbaguidi
127 schema:givenName J.
128 rdf:type schema:Person
129 Nc4092cbdf48f4f7bb4465455d8d51b7a rdf:first Ned57075075844da9b8798d3f7031d392
130 rdf:rest N7312587a185f4ba192523772b5e63ed5
131 Nc51bd00f70954681a3d44f16c9561590 schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 Nc934b8bc88864c9fa0e64f7c7bd802a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Ethanolamines
135 rdf:type schema:DefinedTerm
136 Ncbdf48b1363d475180fba13c188674dc schema:name dimensions_id
137 schema:value pub.1052683693
138 rdf:type schema:PropertyValue
139 Nd9e6f75c39644c76ad1f806d77beaf6c rdf:first sg:person.01052433001.57
140 rdf:rest Nc4092cbdf48f4f7bb4465455d8d51b7a
141 Ne005ea3debc4444ba77c3e17be0f79a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Fluorenes
143 rdf:type schema:DefinedTerm
144 Ne7c4828d401545ceb701fb419e10abd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Artemisinins
146 rdf:type schema:DefinedTerm
147 Ned57075075844da9b8798d3f7031d392 schema:familyName Capo-Chichi
148 schema:givenName L.
149 rdf:type schema:Person
150 Nf8e9528d4b404717ae8601407ce97e30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Drug Administration Schedule
152 rdf:type schema:DefinedTerm
153 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
154 schema:name Medical and Health Sciences
155 rdf:type schema:DefinedTerm
156 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
157 schema:name Clinical Sciences
158 rdf:type schema:DefinedTerm
159 sg:journal.1082087 schema:issn 0037-9085
160 1961-9049
161 schema:name Bulletin de la Société de pathologie exotique
162 rdf:type schema:Periodical
163 sg:person.01052433001.57 schema:affiliation N52b9ba8627284484bdc1b79df6c0a739
164 schema:familyName Ogouyèmi-Hounto
165 schema:givenName A.
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052433001.57
167 rdf:type schema:Person
168 sg:person.01063422436.58 schema:familyName Massougbodji
169 schema:givenName A.
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063422436.58
171 rdf:type schema:Person
172 sg:person.01163337724.84 schema:familyName Kinde-Gazard
173 schema:givenName D.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163337724.84
175 rdf:type schema:Person
176 sg:pub.10.1186/1475-2875-4-46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022561567
177 https://doi.org/10.1186/1475-2875-4-46
178 rdf:type schema:CreativeWork
179 sg:pub.10.1186/1475-2875-7-106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014915280
180 https://doi.org/10.1186/1475-2875-7-106
181 rdf:type schema:CreativeWork
182 sg:pub.10.1186/1475-2875-8-148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012714673
183 https://doi.org/10.1186/1475-2875-8-148
184 rdf:type schema:CreativeWork
185 sg:pub.10.1186/1475-2875-8-196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017310659
186 https://doi.org/10.1186/1475-2875-8-196
187 rdf:type schema:CreativeWork
188 sg:pub.10.1186/1756-3305-3-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042458629
189 https://doi.org/10.1186/1756-3305-3-1
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.actatropica.2003.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015840911
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.actatropica.2009.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033573385
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.trstmh.2004.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054751024
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1111/j.1365-3156.2007.01859.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036389143
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1136/bmj.b2763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016533575
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1371/journal.pctr.0020020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049650617
202 rdf:type schema:CreativeWork
203 https://doi.org/10.3390/ph3123581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042982410
204 rdf:type schema:CreativeWork
205 https://doi.org/10.4269/ajtmh.2010.09-0265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033030250
206 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...