Quantitative Imaging of Alpha-Emitting Therapeutic Radiopharmaceuticals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-18

AUTHORS

Youngho Seo

ABSTRACT

Targeted alpha therapy (TAT) is an active area of drug development as a highly specific and highly potent therapeutic modality that can be applied to many types of late-stage cancers. In order to properly evaluate its safety and efficacy, understanding biokinetics of alpha-emitting radiopharmaceuticals is essential. Quantitative imaging of alpha-emitting radiopharmaceuticals is often possible via imaging of gammas and positrons produced during complex decay chains of these radionuclides. Analysis of the complex decay chains for alpha-emitting radionuclides (Tb-149, At-211, Bi-212 (decayed from Pb-212), Bi-213, Ra-223, Ac-225, and Th-227) with relevance to imageable signals is attempted in this mini-review article. Gamma camera imaging, single-photon emission computed tomography, positron emission tomography, bremsstrahlung radiation imaging, Cerenkov luminescence imaging, and Compton cameras are briefly discussed as modalities for imaging alpha-emitting radiopharmaceuticals. More... »

PAGES

1-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13139-019-00589-8

DOI

http://dx.doi.org/10.1007/s13139-019-00589-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112214229


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