Clinical Applications of Technetium-99m Quantitative Single-Photon Emission Computed Tomography/Computed Tomography View Full Text


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Article Info

DATE

2019-03-15

AUTHORS

Won Woo Lee, K-SPECT Group

ABSTRACT

Single-photon emission computed tomography/computed tomography (SPECT/CT) is an already established nuclear imaging modality. Co-registration of functional information (SPECT) with anatomical images (CT) paved the way to the wider application of SPECT. Recent advancements in quantitative SPECT/CT have made it possible to incorporate quantitative parameters, such as standardized uptake value (SUV) or %injected dose (%ID), in gamma camera imaging. This is indeed a paradigm shift in gamma camera imaging from qualitative to quantitative evaluation. In fact, such quantitative approaches of nuclear imaging have only been accomplished for positron emission tomography (PET) technology. Attenuation correction, scatter correction, and resolution recovery are the three main features that enabled quantitative SPECT/CT. Further technical improvements are being achieved for partial-volume correction, motion correction, and dead-time correction. The reported clinical applications for quantitative SPECT/CT are mainly related to Tc-99m-labeled radiopharmaceuticals: Tc-99m diphosphonate for bone/joint diseases, Tc-99m pertechnetate for thyroid function, and Tc-99m diethylenetriaminepentaacetic acid for measurement of glomerular filtration rate. Dosimetry before trans-arterial radio-embolization is also a promising application for Tc-99m macro-aggregated albumin. In this review, clinical applications of Tc-99m quantitative SPECT/CT will be discussed. More... »

PAGES

1-10

References to SciGraph publications

  • 2017-12. Quantitative Single-Photon Emission Computed Tomography/Computed Tomography for Glomerular Filtration Rate Measurement in NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2017-12. Skeletal standardized uptake values obtained by quantitative SPECT/CT as an osteoblastic biomarker for the discrimination of active bone metastasis in prostate cancer in EUROPEAN JOURNAL OF HYBRID IMAGING
  • 2014-02. Improved measurement of the glomerular filtration rate from Tc-99m DTPA scintigraphy in patients following nephrectomy in EUROPEAN RADIOLOGY
  • 2002-08. The continuing importance of thyroid scintigraphy in the era of high-resolution ultrasound in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2011-05. Absolute quantification in SPECT in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1994-11. Treatment of inoperable hepatocellular carcinoma with intrahepatic arterial yttrium-90 microspheres: a phase I and II study in BRITISH JOURNAL OF CANCER
  • 2016-12. Clinical Meaning of Hot Uptake on Bone Scan in Symptomatic Accessory Navicular Bones in NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2010-04. Sodium Iodide Symporter and the Radioiodine Treatment of Thyroid Carcinoma in NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2018-12. Evaluation of Hot Nodules of Thyroid Gland Using Tc-99m Pertechnetate: a Novel Approach Using Quantitative Single-Photon Emission Computed Tomography/Computed Tomography in NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1998-07. Transmission scanning in emission tomography in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2013-12. Quantification of 99mTc-DPD concentration in the lumbar spine with SPECT/CT in EJNMMI RESEARCH
  • 2018-10. Inverse Prognostic Relationships of 18F-FDG PET/CT Metabolic Parameters in Patients with Distal Bile Duct Cancer Undergoing Curative Surgery in NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2017-06. Comparison of Two Different Segmentation Methods on Planar Lung Perfusion Scan with Reference to Quantitative Value on SPECT/CT in NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2015-03. The Clinical Value of Hybrid Sentinel Lymphoscintigraphy to Predict Metastatic Sentinel Lymph Nodes in Breast Cancer in NUCLEAR MEDICINE AND MOLECULAR IMAGING
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