Comparative Cardiac Phantom Study Using Tc-99m/I-123 and Tl-201/I-123 Tracers with Cadmium-Zinc-Telluride Detector-Based Single-Photon Emission Computed Tomography View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Takanaga Niimi, Mamoru Nanasato, Mitsuo Sugimoto, Hisatoshi Maeda

ABSTRACT

Objective: A recently introduced single-photon emission computed tomography (SPECT), based on cadmium-zinc-telluride (CZT) detectors (D-SPECT), supports high energy resolution for cardiac imaging. Importantly, the high energy resolution may allow simultaneous dual-isotope (SDI) imaging (e.g., using Tc-99m and I-123). We quantitatively evaluated Tc-99m/I-123 SDI imaging by D-SPECT in comparison with conventional T1-201/I-123. Materials and Methods: Energy resolution was measured as a percentage of the full width at half maximum (FWHM) for Tc-99m, I-123, and Tl-201. The impact of cross-talk and reconstructed image contrast were quantified by measuring the contrast-to-noise ratio (CNR), and the transmural defect contrast in the left ventricle wall (C TD) induced by a difference in energy, for combinations of Tc-99m/I-123 or Tl-201/I-123, using an RH-2 cardiac phantom. Corresponding measurement was also carried out in Anger SPECT (A-SPECT). Results: The energy resolution of the D-SPECT system was 5.4%/5.1% for Tc-99m/I-123 and 5.4%/5.3% for Tl-201/I-123, which was approximately two times higher than the A-SPECT. No notable difference was confirmed in the CNRs of the two systems, but T1-201/I-123 showed overall higher value than Tc-99m/I-123. Compared to A-SPECT, C TD of D-SPECT significantly increased with both Tc-99m/I-123 and T1-201/I-123 (p < 0.05). In DSPECT, the combination of Tc-99m/I-123 had a slightly better C TD than T1-201/I-123. In addition, C TD of Tc-99m/I-123 was improved with scatter correction at both nuclides (p < 0.05), but in Tl-201/I-123, no significant improvement was confirmed in I-123 (p > 0.05). Conclusion: D-SPECT was considered to be capable of performing high-quality SDI imaging using Tc-99m/I-123. More... »

PAGES

57-63

References to SciGraph publications

  • 2016-12. Left ventricular function assessment using 123I/99mTc dual-isotope acquisition with two semi-conductor cadmium–zinc–telluride (CZT) cameras: a gated cardiac phantom study in EJNMMI PHYSICS
  • 2016-01. A preliminary feasibility study of simultaneous dual-isotope imaging with a solid-state dedicated cardiac camera for evaluating myocardial perfusion and fatty acid metabolism in HEART AND VESSELS
  • 2013-07. Initial multicentre experience of high-speed myocardial perfusion imaging: comparison between high-speed and conventional single-photon emission computed tomography with angiographic validation in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2010-08. Simultaneous dual-radionuclide myocardial perfusion imaging with a solid-state dedicated cardiac camera in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2016-08. Comparative analysis of cadmium-zincum-telluride cameras dedicated to myocardial perfusion SPECT: A phantom study in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2014-03. Factors affecting the myocardial activity acquired during exercise SPECT with a high-sensitivity cardiac CZT camera as compared with conventional Anger camera in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2013-10. High-efficiency SPECT MPI: Comparison of automated quantification, visual interpretation, and coronary angiography in JOURNAL OF NUCLEAR CARDIOLOGY
  • 1999-10. A new method for crosstalk correction in simultaneous dual-isotope myocardial imaging with Tl-201 and I-123 in ANNALS OF NUCLEAR MEDICINE
  • 2017-12. Evaluation of Cadmium-Zinc-Telluride Detector-based Single-Photon Emission Computed Tomography for Nuclear Cardiology: a Comparison with Conventional Anger Single-Photon Emission Computed Tomography in NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2016-05. Simultaneous acquisition of 99mTc- and 123I-labeled radiotracers using a preclinical SPECT scanner with CZT detectors in ANNALS OF NUCLEAR MEDICINE
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s13139-018-0559-0

    DOI

    http://dx.doi.org/10.1007/s13139-018-0559-0

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30828402


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