Sodium Iodide Symporter (NIS) in the Management of Patients with Thyroid Carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-08-27

AUTHORS

June-Key Chung, Hyun Woo Kim, Haewon Youn, Gi Jeong Cheon

ABSTRACT

Although radioiodine has been applied in thyroid diseases including carcinoma for over 70 years, it was only in 1996 that the basic molecular mechanism of iodine uptake was identified. Iodide is actively transported into the thyroid via a membrane glycoprotein known as sodium iodide symporter (NIS). NIS mediates radioiodine uptake into thyroid normal and cancer cells. The knowledge on NIS expression has provided scientific background to the empirical management of thyroid carcinoma. Based on recent studies of the NIS gene, this paper provides current clinical applications and future studies. More... »

PAGES

325-326

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13139-018-0540-y

DOI

http://dx.doi.org/10.1007/s13139-018-0540-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106366389

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30344779


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "June-Key", 
        "id": "sg:person.0751347234.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751347234.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyun Woo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Youn", 
        "givenName": "Haewon", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheon", 
        "givenName": "Gi Jeong", 
        "id": "sg:person.01333472502.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333472502.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1245/s10434-011-2047-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011034426", 
          "https://doi.org/10.1245/s10434-011-2047-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13139-013-0249-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036352604", 
          "https://doi.org/10.1007/s13139-013-0249-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03346457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044589186", 
          "https://doi.org/10.1007/bf03346457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002590100509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045681756", 
          "https://doi.org/10.1007/s002590100509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1251-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044717502", 
          "https://doi.org/10.1007/s00259-009-1251-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11864-005-0012-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036833215", 
          "https://doi.org/10.1007/s11864-005-0012-3"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-08-27", 
    "datePublishedReg": "2018-08-27", 
    "description": "Although radioiodine has been applied in thyroid diseases including carcinoma for over 70\u00a0years, it was only in 1996 that the basic molecular mechanism of iodine uptake was identified. Iodide is actively transported into the thyroid via a membrane glycoprotein known as sodium iodide symporter (NIS). NIS mediates radioiodine uptake into thyroid normal and cancer cells. The knowledge on NIS expression has provided scientific background to the empirical management of thyroid carcinoma. Based on recent studies of the NIS gene, this paper provides current clinical applications and future studies.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s13139-018-0540-y", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1016285", 
        "issn": [
          "1869-3474", 
          "1869-3482"
        ], 
        "name": "Nuclear Medicine and Molecular Imaging", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "52"
      }
    ], 
    "keywords": [
      "basic molecular mechanisms", 
      "sodium iodide symporter", 
      "molecular mechanisms", 
      "thyroid carcinoma", 
      "NIS gene", 
      "cancer cells", 
      "management of patients", 
      "NIS expression", 
      "symporter", 
      "current clinical applications", 
      "Recent studies", 
      "radioiodine uptake", 
      "thyroid disease", 
      "empirical management", 
      "iodine uptake", 
      "carcinoma", 
      "genes", 
      "uptake", 
      "clinical application", 
      "thyroid", 
      "future studies", 
      "expression", 
      "membrane", 
      "cells", 
      "patients", 
      "disease", 
      "mechanism", 
      "radioiodine", 
      "management", 
      "NIS", 
      "study", 
      "years", 
      "scientific background", 
      "background", 
      "knowledge", 
      "iodide", 
      "applications", 
      "paper"
    ], 
    "name": "Sodium Iodide Symporter (NIS) in the Management of Patients with Thyroid Carcinoma", 
    "pagination": "325-326", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106366389"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13139-018-0540-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30344779"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13139-018-0540-y", 
      "https://app.dimensions.ai/details/publication/pub.1106366389"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_786.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s13139-018-0540-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13139-018-0540-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13139-018-0540-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13139-018-0540-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13139-018-0540-y'


 

This table displays all metadata directly associated to this object as RDF triples.

142 TRIPLES      21 PREDICATES      69 URIs      55 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13139-018-0540-y schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N1b8b77cd9b0b4aa1b667268f2a2fa647
4 schema:citation sg:pub.10.1007/bf03346457
5 sg:pub.10.1007/s00259-009-1251-5
6 sg:pub.10.1007/s002590100509
7 sg:pub.10.1007/s11864-005-0012-3
8 sg:pub.10.1007/s13139-013-0249-x
9 sg:pub.10.1245/s10434-011-2047-y
10 schema:datePublished 2018-08-27
11 schema:datePublishedReg 2018-08-27
12 schema:description Although radioiodine has been applied in thyroid diseases including carcinoma for over 70 years, it was only in 1996 that the basic molecular mechanism of iodine uptake was identified. Iodide is actively transported into the thyroid via a membrane glycoprotein known as sodium iodide symporter (NIS). NIS mediates radioiodine uptake into thyroid normal and cancer cells. The knowledge on NIS expression has provided scientific background to the empirical management of thyroid carcinoma. Based on recent studies of the NIS gene, this paper provides current clinical applications and future studies.
13 schema:genre article
14 schema:isAccessibleForFree true
15 schema:isPartOf N0c7884abadfc4ff0a2239f01ee8036c5
16 N1bff35bd6abc4657ad8a9d5a2360928b
17 sg:journal.1016285
18 schema:keywords NIS
19 NIS expression
20 NIS gene
21 Recent studies
22 applications
23 background
24 basic molecular mechanisms
25 cancer cells
26 carcinoma
27 cells
28 clinical application
29 current clinical applications
30 disease
31 empirical management
32 expression
33 future studies
34 genes
35 iodide
36 iodine uptake
37 knowledge
38 management
39 management of patients
40 mechanism
41 membrane
42 molecular mechanisms
43 paper
44 patients
45 radioiodine
46 radioiodine uptake
47 scientific background
48 sodium iodide symporter
49 study
50 symporter
51 thyroid
52 thyroid carcinoma
53 thyroid disease
54 uptake
55 years
56 schema:name Sodium Iodide Symporter (NIS) in the Management of Patients with Thyroid Carcinoma
57 schema:pagination 325-326
58 schema:productId N07c62cc3afc641428f580f6541ca84e1
59 N6caf2aea60144eac9bb2893a99d0bfbb
60 Nc4b9817cefdf4e249d0b5b23108d499c
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106366389
62 https://doi.org/10.1007/s13139-018-0540-y
63 schema:sdDatePublished 2022-10-01T06:45
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N5c1f789a001c4ef5b9650f2ed04e2143
66 schema:url https://doi.org/10.1007/s13139-018-0540-y
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N07c62cc3afc641428f580f6541ca84e1 schema:name pubmed_id
71 schema:value 30344779
72 rdf:type schema:PropertyValue
73 N0c7884abadfc4ff0a2239f01ee8036c5 schema:issueNumber 5
74 rdf:type schema:PublicationIssue
75 N0ed3d9decdb54fccb2e7918348786af2 rdf:first sg:person.01333472502.31
76 rdf:rest rdf:nil
77 N1678e2b965c045a1a3bf58a6d955184b schema:affiliation grid-institutes:grid.31501.36
78 schema:familyName Youn
79 schema:givenName Haewon
80 rdf:type schema:Person
81 N1b8b77cd9b0b4aa1b667268f2a2fa647 rdf:first sg:person.0751347234.39
82 rdf:rest N7e62b54b6f744d469eb21e97ac0edbf6
83 N1bff35bd6abc4657ad8a9d5a2360928b schema:volumeNumber 52
84 rdf:type schema:PublicationVolume
85 N5c1f789a001c4ef5b9650f2ed04e2143 schema:name Springer Nature - SN SciGraph project
86 rdf:type schema:Organization
87 N6783612011424116a957b5497b3876eb rdf:first N1678e2b965c045a1a3bf58a6d955184b
88 rdf:rest N0ed3d9decdb54fccb2e7918348786af2
89 N6caf2aea60144eac9bb2893a99d0bfbb schema:name doi
90 schema:value 10.1007/s13139-018-0540-y
91 rdf:type schema:PropertyValue
92 N7e62b54b6f744d469eb21e97ac0edbf6 rdf:first Na408e0ee4ea04597bc59d463d9503dd4
93 rdf:rest N6783612011424116a957b5497b3876eb
94 Na408e0ee4ea04597bc59d463d9503dd4 schema:affiliation grid-institutes:grid.31501.36
95 schema:familyName Kim
96 schema:givenName Hyun Woo
97 rdf:type schema:Person
98 Nc4b9817cefdf4e249d0b5b23108d499c schema:name dimensions_id
99 schema:value pub.1106366389
100 rdf:type schema:PropertyValue
101 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
102 schema:name Biological Sciences
103 rdf:type schema:DefinedTerm
104 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
105 schema:name Biochemistry and Cell Biology
106 rdf:type schema:DefinedTerm
107 sg:journal.1016285 schema:issn 1869-3474
108 1869-3482
109 schema:name Nuclear Medicine and Molecular Imaging
110 schema:publisher Springer Nature
111 rdf:type schema:Periodical
112 sg:person.01333472502.31 schema:affiliation grid-institutes:grid.31501.36
113 schema:familyName Cheon
114 schema:givenName Gi Jeong
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333472502.31
116 rdf:type schema:Person
117 sg:person.0751347234.39 schema:affiliation grid-institutes:grid.31501.36
118 schema:familyName Chung
119 schema:givenName June-Key
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751347234.39
121 rdf:type schema:Person
122 sg:pub.10.1007/bf03346457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044589186
123 https://doi.org/10.1007/bf03346457
124 rdf:type schema:CreativeWork
125 sg:pub.10.1007/s00259-009-1251-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044717502
126 https://doi.org/10.1007/s00259-009-1251-5
127 rdf:type schema:CreativeWork
128 sg:pub.10.1007/s002590100509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045681756
129 https://doi.org/10.1007/s002590100509
130 rdf:type schema:CreativeWork
131 sg:pub.10.1007/s11864-005-0012-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036833215
132 https://doi.org/10.1007/s11864-005-0012-3
133 rdf:type schema:CreativeWork
134 sg:pub.10.1007/s13139-013-0249-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036352604
135 https://doi.org/10.1007/s13139-013-0249-x
136 rdf:type schema:CreativeWork
137 sg:pub.10.1245/s10434-011-2047-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1011034426
138 https://doi.org/10.1245/s10434-011-2047-y
139 rdf:type schema:CreativeWork
140 grid-institutes:grid.31501.36 schema:alternateName Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
141 schema:name Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
142 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...