Perspective in Nuclear Theranostics Using Exosome for the Brain View Full Text


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Article Info

DATE

2019-03-31

AUTHORS

Do Won Hwang

ABSTRACT

Owing to its highly biocompatible property as naturally produced nanoscale particle and drug carrying ability, exosome has attracted much interest in the biomedical area. Versatile functions of exosome in biological system play an important role in elucidating mysterious and unknown biological processes and pathological disease progression. For usage of exosome as brain disease therapeutics, even though the ability of exosomes crossing blood brain barrier (BBB) is not well clearly proven, the small size and their own characteristics possessing cell-derived molecular contents may provide great and beneficial tools for brain delivery and brain-associated disease therapy. A variety of trials related to bioapplications using stem cell-derived exosome in regenerative therapy or autologous exosome shuttling inhibitor targeting brain disease-associated protein marker enhance possibility of exosome toward clinical application. The radionuclide PET or SPECT imaging of radiolabeled exosome will be clearly able to provide accurate clues for analyzing their whole body distribution, targeting efficacy, and the degree of non-specific tissue uptake. In this perspective, the practical information on thranostics of exosome for brain delivery and therapy is offered and radionuclide-based exosome applicability will be dealt with. More... »

PAGES

1-7

References to SciGraph publications

  • 2016-11. Exosomes derived from tumor cells genetically modified to express Mycobacterium tuberculosis antigen: a novel vaccine for cancer therapy in BIOTECHNOLOGY LETTERS
  • 2018-12. Recent advancements in the use of exosomes as drug delivery systems in JOURNAL OF NANOBIOTECHNOLOGY
  • 2015-12. Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma in NATURE COMMUNICATIONS
  • 2015-12. Noninvasive imaging of radiolabeled exosome-mimetic nanovesicle using 99mTc-HMPAO in SCIENTIFIC REPORTS
  • 2017-06. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer in NATURE
  • 2018-07-27. Mesenchymal Stem Cells-Derived Exosomes for Wound Regeneration in CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOLUME 4
  • 2018-12. Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis in STEM CELL RESEARCH & THERAPY
  • 2016-12. Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro in CELLULAR AND MOLECULAR BIOENGINEERING
  • 2017-06. Engineering exosomes as refined biological nanoplatforms for drug delivery in ACTA PHARMACOLOGICA SINICA
  • 2018-12. Exosomes exert cardioprotection in dystrophin-deficient cardiomyocytes via ERK1/2-p38/MAPK signaling in SCIENTIFIC REPORTS
  • 2011-04. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes in NATURE BIOTECHNOLOGY
  • 2017-11. Curcumin Encapsulated in Milk Exosomes Resists Human Digestion and Possesses Enhanced Intestinal Permeability in Vitro in APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
  • 2018-10. Mesenchymal stromal cell-derived extracellular vesicles: regenerative and immunomodulatory effects and potential applications in sepsis in CELL AND TISSUE RESEARCH
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