Quantification of Contraction Synchronicity and Contraction Work in Coronary Artery Disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-02-02

AUTHORS

Takanaga Niimi, Mamoru Nanasato, Hisatoshi Maeda

ABSTRACT

PurposeThis study quantified the contraction synchronicity (CS; with 100% representing full synchrony and −100% dyssynchrony) and contraction work (CW, millijoules per centimeter squared; representing myocardial area) in patients with reduced left ventricular ejection fraction (LVEF) associated with coronary artery disease (CAD).MethodsCS, CW and LVEF in 104 subjects (54 CAD patients and 50 control subjects without CAD) were measured using rest electrocardiography-gated single-photon emission computed tomography (ECG SPECT). Contraction amplitude (CA), synchronous contraction index (SCI), and CW were evaluated using the program Quantification of Segmental Function by Solving the Poisson Equation (QSFP) developed in-house.ResultsThe mean CA, SCI and CW of 17 segments in the control subjects were 33.8 ± 4.1% (±SD), 96.6 ± 1.4%, and 6.9 ± 1.0 mJ/cm2, respectively. In the patients with CAD, the respective values were 26.1 ± 7.3%, 82.1 ± 16.8%, and 5.4 ± 1.6 mJ/cm2. In the CAD patients with LVEF <40% (n = 14), the mean CA, SCI,and CW were 17.9 ± 4.0%, 63.0 ± 18.4%, and 3.5 ± 1.1 mJ/cm2, respectively. These values were significantly lower than in the control subjects (p < 0.005). Using receiver operating characteristic analysis, values for the area under the curve showing the performance of CA, CS, CW and LVEF in the diagnosis of CAD were 0.81, 0.86, 0.78, and 0.84, respectively.ConclusionAsynchrony shown using the QSFP is useful for CAD detection. More... »

PAGES

227-232

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13139-017-0472-y

DOI

http://dx.doi.org/10.1007/s13139-017-0472-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083423647

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28878848


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