Clinical Significance of Pretreatment FDG PET/CT in MIBG-Avid Pediatric Neuroblastoma View Full Text


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Article Info

DATE

2016-10-06

AUTHORS

Seo Young Kang, Muhammad Kashif Rahim, Yong-il Kim, Gi Jeong Cheon, Hyoung Jin Kang, Hee Young Shin, Keon Wook Kang, June-Key Chung, E. Edmund Kim, Dong Soo Lee

ABSTRACT

Purpose18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging is well known to have clinical significance in the initial staging and response evaluation of the many kinds of neoplasms. However, its role in the pediatric neuroblastoma is not clearly defined. In the present study, the clinical significance of FDG-PET/computed tomography (CT) in 123I- or 131I-metaiodobenzylguanidine (MIBG)-avid pediatric neuroblastoma was investigated.MethodsTwenty patients with neuroblastoma who undertook pretreatment FDG PET/CT at our institute between 2008 and 2015 and showed MIBG avidity were retrospectively enrolled in the present study. Clinical information—including histopathology, and serum markers—and several PET parameters—including SUVmax of the primary lesion (Psuv), target-to-background ratio (TBR), metabolic tumor volume (MTV), and coefficient of variation (CV)—were analyzed. The prognostic effect of PET parameters was evaluated in terms of progression-free survival (PFS).ResultsTotal 20 patients (4.5 ± 3.5 years) were divided as two groups by disease progression. Six patients (30.0 %) experienced disease progression and one patient (5.0 %) died during follow-up period. There were not statistically significant in age, stage, MYCN status, primary tumor size, serum lactate dehydrogenase (LDH), neuron-specific enolase (NSE), and ferritin level between two groups with progression or no progression. However, Psuv (p = 0.017), TBR (p = 0.09), MTV (p = 0.02), and CV (p = 0.036) showed significant differences between two groups. In univariate analysis, PFS was significantly associated with Psuv (p = 0.021) and TBR (p = 0.023).ConclusionsFDG-PET parameters were significantly related with progression of neuroblastoma. FDG-PET/CT may have the potential as a valuable modality for evaluating prognosis in the patients with MIBG-avid pediatric neuroblastoma. More... »

PAGES

154-160

References to SciGraph publications

  • 2011-09-23. Prognostic value of metabolic tumor burden on 18F-FDG PET in nonsurgical patients with non-small cell lung cancer in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2010-04-27. Criteria for evaluation of disease extent by 123I-metaiodobenzylguanidine scans in neuroblastoma: a report for the International Neuroblastoma Risk Group (INRG) Task Force in BRITISH JOURNAL OF CANCER
  • 2016-04-27. Prognostic value of preoperative intratumoral FDG uptake heterogeneity in patients with epithelial ovarian cancer in EUROPEAN RADIOLOGY
  • 2012-11-14. Nuclear medicine and multimodality imaging of pediatric neuroblastoma in PEDIATRIC RADIOLOGY
  • 2014-09-06. Prognostic value of volumetric parameters of 18F-FDG PET in non-small-cell lung cancer: a meta-analysis in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2002-10-31. Prognostic value of [18F]FDG-PET imaging in small cell lung cancer in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2013-04-05. The utility of FDG PET in diagnosis and follow-up of lymphoma in childhood in EUROPEAN JOURNAL OF PEDIATRICS
  • 2015-02-17. The role of 18F-FDG PET/CT in diagnosis and staging of musculoskeletal soft tissue sarcomas in CLINICAL AND TRANSLATIONAL IMAGING
  • 2016-02-12. Intratumoral heterogeneity of 18F-FDG uptake predicts survival in patients with pancreatic ductal adenocarcinoma in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2014-01-31. 18F-FDG PET as a single imaging modality in pediatric neuroblastoma: comparison with abdomen CT and bone scintigraphy in ANNALS OF NUCLEAR MEDICINE
  • 2002-07-26. FDG uptake in breast cancer: correlation with biological and clinical prognostic parameters in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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    17 schema:description Purpose18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging is well known to have clinical significance in the initial staging and response evaluation of the many kinds of neoplasms. However, its role in the pediatric neuroblastoma is not clearly defined. In the present study, the clinical significance of FDG-PET/computed tomography (CT) in 123I- or 131I-metaiodobenzylguanidine (MIBG)-avid pediatric neuroblastoma was investigated.MethodsTwenty patients with neuroblastoma who undertook pretreatment FDG PET/CT at our institute between 2008 and 2015 and showed MIBG avidity were retrospectively enrolled in the present study. Clinical information—including histopathology, and serum markers—and several PET parameters—including SUVmax of the primary lesion (Psuv), target-to-background ratio (TBR), metabolic tumor volume (MTV), and coefficient of variation (CV)—were analyzed. The prognostic effect of PET parameters was evaluated in terms of progression-free survival (PFS).ResultsTotal 20 patients (4.5 ± 3.5 years) were divided as two groups by disease progression. Six patients (30.0 %) experienced disease progression and one patient (5.0 %) died during follow-up period. There were not statistically significant in age, stage, MYCN status, primary tumor size, serum lactate dehydrogenase (LDH), neuron-specific enolase (NSE), and ferritin level between two groups with progression or no progression. However, Psuv (p = 0.017), TBR (p = 0.09), MTV (p = 0.02), and CV (p = 0.036) showed significant differences between two groups. In univariate analysis, PFS was significantly associated with Psuv (p = 0.021) and TBR (p = 0.023).ConclusionsFDG-PET parameters were significantly related with progression of neuroblastoma. FDG-PET/CT may have the potential as a valuable modality for evaluating prognosis in the patients with MIBG-avid pediatric neuroblastoma.
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    24 Emission Tomography Imaging
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    29 MYCN status
    30 MethodsTwenty patients
    31 PET parameters
    32 PET/CT
    33 SUVmax
    34 TBR
    35 age
    36 analysis
    37 avidity
    38 background ratio
    39 clinical significance
    40 coefficient
    41 coefficient of variation
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    46 effect
    47 enolase
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    49 ferritin levels
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    54 kind
    55 kind of neoplasm
    56 lactate dehydrogenase
    57 lesions
    58 levels
    59 markers
    60 metabolic tumor volume
    61 modalities
    62 neoplasms
    63 neuroblastoma
    64 neuron-specific enolase
    65 pSUV
    66 parameters
    67 patients
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    69 period
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    72 pretreatment FDG PET/CT
    73 primary lesion
    74 primary tumor size
    75 prognosis
    76 prognostic effect
    77 progression
    78 progression of neuroblastoma
    79 progression-free survival
    80 ratio
    81 response evaluation
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    83 serum lactate dehydrogenase
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