Application of a Small Molecule Radiopharmaceutical Concept to Improve Kinetics View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-09-28

AUTHORS

Jae Min Jeong

ABSTRACT

Recently, large molecules or nanoparticles are actively studied as radiopharmaceuticals. However, their kinetics is problematic because of a slow penetration through the capillaries and slow distribution to the target. To improve the kinetics, a two-step targeting method can be applied by using small molecules and very rapid copper-free click reaction. Although this method might have limitations such as internalization of the first targeted conjugate, it will provide high target-to-non-target ratio imaging of radiopharmaceuticals. More... »

PAGES

99-101

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13139-015-0369-6

DOI

http://dx.doi.org/10.1007/s13139-015-0369-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047366873

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27275356


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0303", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Macromolecular and Materials Chemistry", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, Seoul National University Hospital, 101 Daehak-ro Jongno-gu, 110-744, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea", 
            "Department of Nuclear Medicine, Seoul National University Hospital, 101 Daehak-ro Jongno-gu, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeong", 
        "givenName": "Jae Min", 
        "id": "sg:person.01301360400.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301360400.94"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/978-1-4939-2288-8_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031512290", 
          "https://doi.org/10.1007/978-1-4939-2288-8_5"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-09-28", 
    "datePublishedReg": "2015-09-28", 
    "description": "Recently, large molecules or nanoparticles are actively studied as radiopharmaceuticals. However, their kinetics is problematic because of a slow penetration through the capillaries and slow distribution to the target. To improve the kinetics, a two-step targeting method can be applied by using small molecules and very rapid copper-free click reaction. Although this method might have limitations such as internalization of the first targeted conjugate, it will provide high target-to-non-target ratio imaging of radiopharmaceuticals.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s13139-015-0369-6", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1016285", 
        "issn": [
          "1869-3474", 
          "1869-3482"
        ], 
        "name": "Nuclear Medicine and Molecular Imaging", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "50"
      }
    ], 
    "keywords": [
      "copper-free click reaction", 
      "click reaction", 
      "small molecules", 
      "large molecules", 
      "two-step targeting method", 
      "molecules", 
      "kinetics", 
      "nanoparticles", 
      "slow penetration", 
      "reaction", 
      "radiopharmaceuticals", 
      "high target", 
      "method", 
      "capillaries", 
      "applications", 
      "slow distribution", 
      "targeting method", 
      "internalization", 
      "ratio imaging", 
      "penetration", 
      "target", 
      "distribution", 
      "imaging", 
      "limitations", 
      "concept"
    ], 
    "name": "Application of a Small Molecule Radiopharmaceutical Concept to Improve Kinetics", 
    "pagination": "99-101", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047366873"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13139-015-0369-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27275356"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13139-015-0369-6", 
      "https://app.dimensions.ai/details/publication/pub.1047366873"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_675.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s13139-015-0369-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13139-015-0369-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13139-015-0369-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13139-015-0369-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13139-015-0369-6'


 

This table displays all metadata directly associated to this object as RDF triples.

91 TRIPLES      21 PREDICATES      51 URIs      42 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13139-015-0369-6 schema:about anzsrc-for:03
2 anzsrc-for:0303
3 schema:author N0a288097b5ec4e3db7898c44e1ae18be
4 schema:citation sg:pub.10.1007/978-1-4939-2288-8_5
5 schema:datePublished 2015-09-28
6 schema:datePublishedReg 2015-09-28
7 schema:description Recently, large molecules or nanoparticles are actively studied as radiopharmaceuticals. However, their kinetics is problematic because of a slow penetration through the capillaries and slow distribution to the target. To improve the kinetics, a two-step targeting method can be applied by using small molecules and very rapid copper-free click reaction. Although this method might have limitations such as internalization of the first targeted conjugate, it will provide high target-to-non-target ratio imaging of radiopharmaceuticals.
8 schema:genre article
9 schema:isAccessibleForFree true
10 schema:isPartOf N29b0ec3ba3c5433b8ca42d97317ea85a
11 Na7c664339ca14b0a815d26c038b2ecfc
12 sg:journal.1016285
13 schema:keywords applications
14 capillaries
15 click reaction
16 concept
17 copper-free click reaction
18 distribution
19 high target
20 imaging
21 internalization
22 kinetics
23 large molecules
24 limitations
25 method
26 molecules
27 nanoparticles
28 penetration
29 radiopharmaceuticals
30 ratio imaging
31 reaction
32 slow distribution
33 slow penetration
34 small molecules
35 target
36 targeting method
37 two-step targeting method
38 schema:name Application of a Small Molecule Radiopharmaceutical Concept to Improve Kinetics
39 schema:pagination 99-101
40 schema:productId N650152ebe2544181933a959b593b1356
41 Nb1bb4b20776b43469bac5093e2f34a8c
42 Nc97d2c14ad264cb090f3e6ea6cfe0971
43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047366873
44 https://doi.org/10.1007/s13139-015-0369-6
45 schema:sdDatePublished 2022-10-01T06:41
46 schema:sdLicense https://scigraph.springernature.com/explorer/license/
47 schema:sdPublisher N603c3c621a504e6d95d4c37d18fb5527
48 schema:url https://doi.org/10.1007/s13139-015-0369-6
49 sgo:license sg:explorer/license/
50 sgo:sdDataset articles
51 rdf:type schema:ScholarlyArticle
52 N0a288097b5ec4e3db7898c44e1ae18be rdf:first sg:person.01301360400.94
53 rdf:rest rdf:nil
54 N29b0ec3ba3c5433b8ca42d97317ea85a schema:issueNumber 2
55 rdf:type schema:PublicationIssue
56 N603c3c621a504e6d95d4c37d18fb5527 schema:name Springer Nature - SN SciGraph project
57 rdf:type schema:Organization
58 N650152ebe2544181933a959b593b1356 schema:name doi
59 schema:value 10.1007/s13139-015-0369-6
60 rdf:type schema:PropertyValue
61 Na7c664339ca14b0a815d26c038b2ecfc schema:volumeNumber 50
62 rdf:type schema:PublicationVolume
63 Nb1bb4b20776b43469bac5093e2f34a8c schema:name dimensions_id
64 schema:value pub.1047366873
65 rdf:type schema:PropertyValue
66 Nc97d2c14ad264cb090f3e6ea6cfe0971 schema:name pubmed_id
67 schema:value 27275356
68 rdf:type schema:PropertyValue
69 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
70 schema:name Chemical Sciences
71 rdf:type schema:DefinedTerm
72 anzsrc-for:0303 schema:inDefinedTermSet anzsrc-for:
73 schema:name Macromolecular and Materials Chemistry
74 rdf:type schema:DefinedTerm
75 sg:journal.1016285 schema:issn 1869-3474
76 1869-3482
77 schema:name Nuclear Medicine and Molecular Imaging
78 schema:publisher Springer Nature
79 rdf:type schema:Periodical
80 sg:person.01301360400.94 schema:affiliation grid-institutes:grid.412484.f
81 schema:familyName Jeong
82 schema:givenName Jae Min
83 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301360400.94
84 rdf:type schema:Person
85 sg:pub.10.1007/978-1-4939-2288-8_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031512290
86 https://doi.org/10.1007/978-1-4939-2288-8_5
87 rdf:type schema:CreativeWork
88 grid-institutes:grid.412484.f schema:alternateName Department of Nuclear Medicine, Seoul National University Hospital, 101 Daehak-ro Jongno-gu, 110-744, Seoul, Korea
89 schema:name Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
90 Department of Nuclear Medicine, Seoul National University Hospital, 101 Daehak-ro Jongno-gu, 110-744, Seoul, Korea
91 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...