The Clinical Usefulness of 18F-FDG PET/CT in Patients with Systemic Autoimmune Disease View Full Text


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Article Info

DATE

2011-09

AUTHORS

Jong-Ryool Oh, Ho-Chun Song, Sae-Ryung Kang, Su-Woong Yoo, Jahae Kim, Ari Chong, Jung-Joon Min, Hee-Seung Bom, Shin-Seok Lee, Yong-Wook Park

ABSTRACT

PURPOSE: Individuals with systemic autoimmune disease have an increased susceptibility to both inflammation and malignancy. The aim of this study was to evaluate the clinical usefulness of (18)F-FDG PET/CT in patients with systemic autoimmune disease. METHODS: Forty patients diagnosed with systemic autoimmune disease were enrolled. Diagnostic accuracy of FDG PET/CT for detecting malignancy was assessed. FDG PET/CT findings, including maximum standardized uptake (SUVmax) of lymphadenopathy (LAP), liver, bone marrow, spleen, joint and muscles, were considered for the characterization of LAPs. RESULTS: FDG PET/CT could detect metabolically activated lesions in 36 out of 40 patients (90%) including inflammatory lesions in 28 out of 32 patients (88%). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of FDG PET/CT for the detection of malignancy were 100, 67, 70, 25, and 100%, respectively. Multiple LAPs were found in 25 of 40 patients (63%), and comprised three malignancies, four cases of tuberculosis, and 18 reactive changes. A SUVmax ratio of bone marrow to liver below 0.78 could distinguish malignancy from tuberculosis + reactive change (AUC = 1.000, sensitivity: 100%, specificity: 100%). The SUVmax ratio of spleen to liver in the reactive group was also significantly higher than that in the malignancy group (P = 0.014). SUVmax of LAP in the TB group was significantly higher than that in the reactive group (P = 0.040). CONCLUSIONS: PET/CT is useful in detecting and differentiating inflammation and malignancy in patients with systemic autoimmune disease. Frequent false-positive interpretations can be minimized by consideration of FDG uptake in bone marrow and spleen. More... »

PAGES

177

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    URI

    http://scigraph.springernature.com/pub.10.1007/s13139-011-0094-8

    DOI

    http://dx.doi.org/10.1007/s13139-011-0094-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043101857

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24900001


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