Development of 166Ho-phytate Complex for Radiosynovectomy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-06

AUTHORS

Amir R. Jalilian, Akbar Anvari, Ali Bahrami-Samani, Mohammad Mazidi, Mohammad Ghannadi-Maragheh

ABSTRACT

BACKGROUND: (66)Ho-chloride was obtained by bombardment of natural Ho(NO3)3 dissolved in acidic media using thermal neutron flux (4-5 × 10(13) n.cm(-2).s(-1)). METHODS: (166)Ho-holmium chloride (185 MBq) was used successfully for preparation of (166)Ho-phytate complex with high radiochemical purity (>99.9 %, ITLC, MeOH: H2O: acetic acid, 4: 4: 2, as mobile phase). The complex stability and viscosity were checked in the final solution up to 2 days. The prepared complex solution (60 μCi/100 μl) was injected intraarticularly to male rat knee joints. Leakage of radioactivity from the injection site and its distribution in organs were investigated up to 2 days. RESULTS: Approximately all of the injected dose had remained in the injection site 2 days after injection. CONCLUSION: The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology. More... »

PAGES

87-92

References to SciGraph publications

  • 2000-06. Treatment of Bowen’s disease with a specially designed radioactive skin patch in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13139-010-0048-6

    DOI

    http://dx.doi.org/10.1007/s13139-010-0048-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025260488

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24899986


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