Regulatory roles of miR-155 and let-7b on the expression of inflammation-related genes in THP-1 cells: effects of fatty acids View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11

AUTHORS

J.L. Marques-Rocha, M. Garcia-Lacarte, M. Samblas, J. Bressan, J.A. Martínez, F.I. Milagro

ABSTRACT

The main aim of this investigation was to study the regulatory roles of let-7b and miR-155-3p on the expression of inflammation-associated genes in monocytes, macrophages, and lipopolysaccharide (LPS)-activated macrophages (AcM). A second goal was to analyze the potential modulatory roles of different fatty acids, including oleic, palmitic, eicosapentaenoic (EPA), and docosahexaenoic (DHA), on the expression of these miRNAs in the three cell types. This hypothesis was tested in human acute monocytic leukemia cells (THP-1), which were differentiated into macrophages with 2-O-tetradecanoylphorbol-13-acetate (TPA) and further activated with LPS for 24 h. Monocytes, macrophages, and AcM were transfected with a negative control, or mimics for miR-155-3p and miR-let-7b-5p. The expression of both miRNAs and some proinflammatory genes was analyzed by qRT-PCR. Interestingly, let-7b mimic reduced the expression of IL6 and TNF in monocytes, and SERPINE1 expression in LPS-activated macrophages. However, IL6, TNF, and SERPINE1 were upregulated in macrophages by let-7b mimic. IL6 expression was higher in the three types of cells after transfecting with miR-155-3p mimic. Similarly, expression of SERPINE1 was increased by miR-155-3p mimic in monocytes and macrophages. However, TLR4 was downregulated by miR-155-3p in monocytes and macrophages. Regarding the effects of the different fatty acids, oleic acid increased the expression of let-7b in macrophages and AcM and also increased the expression of miR-155 in monocytes when compared with DHA but not when compared with non-treated cells. Overall, these results suggest anti- and proinflammatory roles of let-7b and miR-155-3p in THP-1 cells, respectively, although these outcomes are strongly dependent on the cell type. Noteworthy, oleic acid might exert beneficial anti-inflammatory effects in immune cells (i.e., non-activated and LPS-activated macrophages) by upregulating the expression of let-7b. More... »

PAGES

1-11

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13105-018-0629-x

DOI

http://dx.doi.org/10.1007/s13105-018-0629-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104142576

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29790117


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universidade Federal do Esp\u00edrito Santo", 
          "id": "https://www.grid.ac/institutes/grid.412371.2", 
          "name": [
            "Department of Integrated Education of Health, Federal University of Espirito Santo, Vit\u00f3ria, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marques-Rocha", 
        "givenName": "J.L.", 
        "id": "sg:person.01116011144.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116011144.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Navarra", 
          "id": "https://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Department of Nutrition, Food Science and Physiology; Centre for Nutrition Research, University of Navarra, c / Irunlarrea 1, 31008, Pamplona, Navarra, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garcia-Lacarte", 
        "givenName": "M.", 
        "id": "sg:person.01262134637.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262134637.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Navarra", 
          "id": "https://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Department of Nutrition, Food Science and Physiology; Centre for Nutrition Research, University of Navarra, c / Irunlarrea 1, 31008, Pamplona, Navarra, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Samblas", 
        "givenName": "M.", 
        "id": "sg:person.0661735243.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661735243.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidade Federal de Vi\u00e7osa", 
          "id": "https://www.grid.ac/institutes/grid.12799.34", 
          "name": [
            "Department of Nutrition and Health, Federal University of Vi\u00e7osa, Vi\u00e7osa, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bressan", 
        "givenName": "J.", 
        "id": "sg:person.0752757661.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752757661.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "IMDEA Food", 
          "id": "https://www.grid.ac/institutes/grid.482878.9", 
          "name": [
            "Department of Nutrition, Food Science and Physiology; Centre for Nutrition Research, University of Navarra, c / Irunlarrea 1, 31008, Pamplona, Navarra, Spain", 
            "CIBERobn, Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n, Carlos III Health Institute, Madrid, Spain", 
            "IdiSNA, Navarra Institute for Health Research, Pamplona, Spain", 
            "IMDEA Food, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00ednez", 
        "givenName": "J.A.", 
        "id": "sg:person.01052334317.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052334317.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Salud Carlos III", 
          "id": "https://www.grid.ac/institutes/grid.413448.e", 
          "name": [
            "Department of Nutrition, Food Science and Physiology; Centre for Nutrition Research, University of Navarra, c / Irunlarrea 1, 31008, Pamplona, Navarra, Spain", 
            "CIBERobn, Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n, Carlos III Health Institute, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milagro", 
        "givenName": "F.I.", 
        "id": "sg:person.01120447517.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120447517.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1042/cs20100015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000879017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20100015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000879017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20100015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000879017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamcr.2014.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001245094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jgh.12644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001275520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1019536108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004377772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.14-260323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004816916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-4716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005159613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0056709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006773332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fgene.2015.00340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007814720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2013.09.069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007893145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-015-0237-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010968622", 
          "https://doi.org/10.1186/s12933-015-0237-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-015-0237-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010968622", 
          "https://doi.org/10.1186/s12933-015-0237-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.201400191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012567706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m513304200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013512789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/208309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014817349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1149460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015783172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt1181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016904256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12967-015-0642-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017018235", 
          "https://doi.org/10.1186/s12967-015-0642-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.146852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017812316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.23967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018161921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0019439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020112836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg3765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022795700", 
          "https://doi.org/10.1038/nrg3765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nut.2015.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025525610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2015.11.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026758100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0610731104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029293805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms141123086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031615725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/apha.12022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032027934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar2493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032546212", 
          "https://doi.org/10.1186/ar2493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/jn.113.189050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033093550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2010.05.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033178864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000345826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033541492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mnfr.201400705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033806871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12015-015-9589-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035461919", 
          "https://doi.org/10.1007/s12015-015-9589-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db14-1098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037222897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-10-478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038384938", 
          "https://doi.org/10.1186/1471-2164-10-478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039236419", 
          "https://doi.org/10.1038/nature04516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039236419", 
          "https://doi.org/10.1038/nature04516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039236419", 
          "https://doi.org/10.1038/nature04516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041332849", 
          "https://doi.org/10.1038/nrm2083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4790-14.2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043409600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.10-169599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043431472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgp245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044565170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.179.8.5082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046618236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0811073106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046995590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0605298103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049075000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02979-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049679651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20150224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056717051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20150224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056717051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0000000000000510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086047785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0000000000000510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086047785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m117.809053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092345952"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-11", 
    "datePublishedReg": "2018-11-01", 
    "description": "The main aim of this investigation was to study the regulatory roles of let-7b and miR-155-3p on the expression of inflammation-associated genes in monocytes, macrophages, and lipopolysaccharide (LPS)-activated macrophages (AcM). A second goal was to analyze the potential modulatory roles of different fatty acids, including oleic, palmitic, eicosapentaenoic (EPA), and docosahexaenoic (DHA), on the expression of these miRNAs in the three cell types. This hypothesis was tested in human acute monocytic leukemia cells (THP-1), which were differentiated into macrophages with 2-O-tetradecanoylphorbol-13-acetate (TPA) and further activated with LPS for 24\u00a0h. Monocytes, macrophages, and AcM were transfected with a negative control, or mimics for miR-155-3p and miR-let-7b-5p. The expression of both miRNAs and some proinflammatory genes was analyzed by qRT-PCR. Interestingly, let-7b mimic reduced the expression of IL6 and TNF in monocytes, and SERPINE1 expression in LPS-activated macrophages. However, IL6, TNF, and SERPINE1 were upregulated in macrophages by let-7b mimic. IL6 expression was higher in the three types of cells after transfecting with miR-155-3p mimic. Similarly, expression of SERPINE1 was increased by miR-155-3p mimic in monocytes and macrophages. However, TLR4 was downregulated by miR-155-3p in monocytes and macrophages. Regarding the effects of the different fatty acids, oleic acid increased the expression of let-7b in macrophages and AcM and also increased the expression of miR-155 in monocytes when compared with DHA but not when compared with non-treated cells. Overall, these results suggest anti- and proinflammatory roles of let-7b and miR-155-3p in THP-1 cells, respectively, although these outcomes are strongly dependent on the cell type. Noteworthy, oleic acid might exert beneficial anti-inflammatory effects in immune cells (i.e., non-activated and LPS-activated macrophages) by upregulating the expression of let-7b.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s13105-018-0629-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018705", 
        "issn": [
          "1138-7548", 
          "1877-8755"
        ], 
        "name": "Journal of Physiology and Biochemistry", 
        "type": "Periodical"
      }
    ], 
    "name": "Regulatory roles of miR-155 and let-7b on the expression of inflammation-related genes in THP-1 cells: effects of fatty acids", 
    "pagination": "1-11", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2ed7e6284988ae6f616938bdafe53ae07aeacd7bd9b9c0e2a413be9b1ec030fe"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29790117"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9812509"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13105-018-0629-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104142576"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13105-018-0629-x", 
      "https://app.dimensions.ai/details/publication/pub.1104142576"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000604.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs13105-018-0629-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13105-018-0629-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13105-018-0629-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13105-018-0629-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13105-018-0629-x'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      21 PREDICATES      72 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13105-018-0629-x schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N0da678cb863a479690871eef076276df
4 schema:citation sg:pub.10.1007/s12015-015-9589-5
5 sg:pub.10.1038/nature04516
6 sg:pub.10.1038/nrg3765
7 sg:pub.10.1038/nrm2083
8 sg:pub.10.1186/1471-2164-10-478
9 sg:pub.10.1186/ar2493
10 sg:pub.10.1186/s12933-015-0237-9
11 sg:pub.10.1186/s12967-015-0642-6
12 https://doi.org/10.1002/ana.23967
13 https://doi.org/10.1002/bies.201400191
14 https://doi.org/10.1002/mnfr.201400705
15 https://doi.org/10.1016/j.atherosclerosis.2015.11.015
16 https://doi.org/10.1016/j.bbamcr.2014.04.004
17 https://doi.org/10.1016/j.ejphar.2010.05.061
18 https://doi.org/10.1016/j.jacc.2013.09.069
19 https://doi.org/10.1016/j.nut.2015.06.008
20 https://doi.org/10.1042/bj20150224
21 https://doi.org/10.1042/cs20100015
22 https://doi.org/10.1073/pnas.0605298103
23 https://doi.org/10.1073/pnas.0610731104
24 https://doi.org/10.1073/pnas.0811073106
25 https://doi.org/10.1073/pnas.1019536108
26 https://doi.org/10.1074/jbc.m110.146852
27 https://doi.org/10.1074/jbc.m117.809053
28 https://doi.org/10.1074/jbc.m513304200
29 https://doi.org/10.1093/carcin/bgp245
30 https://doi.org/10.1093/nar/gkt1181
31 https://doi.org/10.1096/fj.10-169599
32 https://doi.org/10.1096/fj.14-260323
33 https://doi.org/10.1111/apha.12022
34 https://doi.org/10.1111/jgh.12644
35 https://doi.org/10.1126/science.1149460
36 https://doi.org/10.1128/jvi.02979-13
37 https://doi.org/10.1155/2013/208309
38 https://doi.org/10.1158/0008-5472.can-06-4716
39 https://doi.org/10.1159/000345826
40 https://doi.org/10.1161/cir.0000000000000510
41 https://doi.org/10.1371/journal.pone.0019439
42 https://doi.org/10.1371/journal.pone.0056709
43 https://doi.org/10.1523/jneurosci.4790-14.2015
44 https://doi.org/10.2337/db14-1098
45 https://doi.org/10.3389/fgene.2015.00340
46 https://doi.org/10.3390/ijms141123086
47 https://doi.org/10.3945/jn.113.189050
48 https://doi.org/10.4049/jimmunol.179.8.5082
49 schema:datePublished 2018-11
50 schema:datePublishedReg 2018-11-01
51 schema:description The main aim of this investigation was to study the regulatory roles of let-7b and miR-155-3p on the expression of inflammation-associated genes in monocytes, macrophages, and lipopolysaccharide (LPS)-activated macrophages (AcM). A second goal was to analyze the potential modulatory roles of different fatty acids, including oleic, palmitic, eicosapentaenoic (EPA), and docosahexaenoic (DHA), on the expression of these miRNAs in the three cell types. This hypothesis was tested in human acute monocytic leukemia cells (THP-1), which were differentiated into macrophages with 2-O-tetradecanoylphorbol-13-acetate (TPA) and further activated with LPS for 24 h. Monocytes, macrophages, and AcM were transfected with a negative control, or mimics for miR-155-3p and miR-let-7b-5p. The expression of both miRNAs and some proinflammatory genes was analyzed by qRT-PCR. Interestingly, let-7b mimic reduced the expression of IL6 and TNF in monocytes, and SERPINE1 expression in LPS-activated macrophages. However, IL6, TNF, and SERPINE1 were upregulated in macrophages by let-7b mimic. IL6 expression was higher in the three types of cells after transfecting with miR-155-3p mimic. Similarly, expression of SERPINE1 was increased by miR-155-3p mimic in monocytes and macrophages. However, TLR4 was downregulated by miR-155-3p in monocytes and macrophages. Regarding the effects of the different fatty acids, oleic acid increased the expression of let-7b in macrophages and AcM and also increased the expression of miR-155 in monocytes when compared with DHA but not when compared with non-treated cells. Overall, these results suggest anti- and proinflammatory roles of let-7b and miR-155-3p in THP-1 cells, respectively, although these outcomes are strongly dependent on the cell type. Noteworthy, oleic acid might exert beneficial anti-inflammatory effects in immune cells (i.e., non-activated and LPS-activated macrophages) by upregulating the expression of let-7b.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf sg:journal.1018705
56 schema:name Regulatory roles of miR-155 and let-7b on the expression of inflammation-related genes in THP-1 cells: effects of fatty acids
57 schema:pagination 1-11
58 schema:productId N0c9946b9881b42f9a0e2e5686ba194a7
59 N1eb6f9c8be2a4e769b315524c2b38882
60 N367db2ae1e2146acb034e8f884dd159b
61 N8aa11df76a5d487e8108adea8dc1dea5
62 Nb82498ba4d844eaa8c521e767e56df27
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104142576
64 https://doi.org/10.1007/s13105-018-0629-x
65 schema:sdDatePublished 2019-04-10T14:24
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher Nd879809d6cdf4dde85018a33c7efa4cc
68 schema:url https://link.springer.com/10.1007%2Fs13105-018-0629-x
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N0c9946b9881b42f9a0e2e5686ba194a7 schema:name dimensions_id
73 schema:value pub.1104142576
74 rdf:type schema:PropertyValue
75 N0da678cb863a479690871eef076276df rdf:first sg:person.01116011144.49
76 rdf:rest Nec72a9a11d16426095a792804a59e294
77 N102674a1d02641cb83986350690d9bf3 rdf:first sg:person.0661735243.05
78 rdf:rest Ncdd7822098a545ec931f076113af2158
79 N1eb6f9c8be2a4e769b315524c2b38882 schema:name pubmed_id
80 schema:value 29790117
81 rdf:type schema:PropertyValue
82 N25999124bdb74b45accf8b0ff02ebb82 rdf:first sg:person.01052334317.42
83 rdf:rest Nb5db1b493dd345cfa8dace9d7fa848cb
84 N367db2ae1e2146acb034e8f884dd159b schema:name nlm_unique_id
85 schema:value 9812509
86 rdf:type schema:PropertyValue
87 N8aa11df76a5d487e8108adea8dc1dea5 schema:name readcube_id
88 schema:value 2ed7e6284988ae6f616938bdafe53ae07aeacd7bd9b9c0e2a413be9b1ec030fe
89 rdf:type schema:PropertyValue
90 Nb5db1b493dd345cfa8dace9d7fa848cb rdf:first sg:person.01120447517.99
91 rdf:rest rdf:nil
92 Nb82498ba4d844eaa8c521e767e56df27 schema:name doi
93 schema:value 10.1007/s13105-018-0629-x
94 rdf:type schema:PropertyValue
95 Ncdd7822098a545ec931f076113af2158 rdf:first sg:person.0752757661.89
96 rdf:rest N25999124bdb74b45accf8b0ff02ebb82
97 Nd879809d6cdf4dde85018a33c7efa4cc schema:name Springer Nature - SN SciGraph project
98 rdf:type schema:Organization
99 Nec72a9a11d16426095a792804a59e294 rdf:first sg:person.01262134637.71
100 rdf:rest N102674a1d02641cb83986350690d9bf3
101 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
102 schema:name Medical and Health Sciences
103 rdf:type schema:DefinedTerm
104 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
105 schema:name Immunology
106 rdf:type schema:DefinedTerm
107 sg:journal.1018705 schema:issn 1138-7548
108 1877-8755
109 schema:name Journal of Physiology and Biochemistry
110 rdf:type schema:Periodical
111 sg:person.01052334317.42 schema:affiliation https://www.grid.ac/institutes/grid.482878.9
112 schema:familyName Martínez
113 schema:givenName J.A.
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052334317.42
115 rdf:type schema:Person
116 sg:person.01116011144.49 schema:affiliation https://www.grid.ac/institutes/grid.412371.2
117 schema:familyName Marques-Rocha
118 schema:givenName J.L.
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116011144.49
120 rdf:type schema:Person
121 sg:person.01120447517.99 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
122 schema:familyName Milagro
123 schema:givenName F.I.
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120447517.99
125 rdf:type schema:Person
126 sg:person.01262134637.71 schema:affiliation https://www.grid.ac/institutes/grid.5924.a
127 schema:familyName Garcia-Lacarte
128 schema:givenName M.
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262134637.71
130 rdf:type schema:Person
131 sg:person.0661735243.05 schema:affiliation https://www.grid.ac/institutes/grid.5924.a
132 schema:familyName Samblas
133 schema:givenName M.
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661735243.05
135 rdf:type schema:Person
136 sg:person.0752757661.89 schema:affiliation https://www.grid.ac/institutes/grid.12799.34
137 schema:familyName Bressan
138 schema:givenName J.
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752757661.89
140 rdf:type schema:Person
141 sg:pub.10.1007/s12015-015-9589-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035461919
142 https://doi.org/10.1007/s12015-015-9589-5
143 rdf:type schema:CreativeWork
144 sg:pub.10.1038/nature04516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039236419
145 https://doi.org/10.1038/nature04516
146 rdf:type schema:CreativeWork
147 sg:pub.10.1038/nrg3765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022795700
148 https://doi.org/10.1038/nrg3765
149 rdf:type schema:CreativeWork
150 sg:pub.10.1038/nrm2083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041332849
151 https://doi.org/10.1038/nrm2083
152 rdf:type schema:CreativeWork
153 sg:pub.10.1186/1471-2164-10-478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038384938
154 https://doi.org/10.1186/1471-2164-10-478
155 rdf:type schema:CreativeWork
156 sg:pub.10.1186/ar2493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032546212
157 https://doi.org/10.1186/ar2493
158 rdf:type schema:CreativeWork
159 sg:pub.10.1186/s12933-015-0237-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010968622
160 https://doi.org/10.1186/s12933-015-0237-9
161 rdf:type schema:CreativeWork
162 sg:pub.10.1186/s12967-015-0642-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017018235
163 https://doi.org/10.1186/s12967-015-0642-6
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1002/ana.23967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018161921
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1002/bies.201400191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012567706
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1002/mnfr.201400705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033806871
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/j.atherosclerosis.2015.11.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026758100
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/j.bbamcr.2014.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001245094
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/j.ejphar.2010.05.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033178864
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/j.jacc.2013.09.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007893145
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.nut.2015.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025525610
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1042/bj20150224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056717051
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1042/cs20100015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000879017
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1073/pnas.0605298103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049075000
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1073/pnas.0610731104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029293805
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1073/pnas.0811073106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046995590
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1073/pnas.1019536108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004377772
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1074/jbc.m110.146852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017812316
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1074/jbc.m117.809053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092345952
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1074/jbc.m513304200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013512789
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1093/carcin/bgp245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044565170
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1093/nar/gkt1181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016904256
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1096/fj.10-169599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043431472
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1096/fj.14-260323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004816916
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1111/apha.12022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032027934
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1111/jgh.12644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001275520
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1126/science.1149460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015783172
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1128/jvi.02979-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049679651
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1155/2013/208309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014817349
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1158/0008-5472.can-06-4716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005159613
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1159/000345826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033541492
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1161/cir.0000000000000510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086047785
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1371/journal.pone.0019439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020112836
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1371/journal.pone.0056709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006773332
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1523/jneurosci.4790-14.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043409600
228 rdf:type schema:CreativeWork
229 https://doi.org/10.2337/db14-1098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037222897
230 rdf:type schema:CreativeWork
231 https://doi.org/10.3389/fgene.2015.00340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007814720
232 rdf:type schema:CreativeWork
233 https://doi.org/10.3390/ijms141123086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031615725
234 rdf:type schema:CreativeWork
235 https://doi.org/10.3945/jn.113.189050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033093550
236 rdf:type schema:CreativeWork
237 https://doi.org/10.4049/jimmunol.179.8.5082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046618236
238 rdf:type schema:CreativeWork
239 https://www.grid.ac/institutes/grid.12799.34 schema:alternateName Universidade Federal de Viçosa
240 schema:name Department of Nutrition and Health, Federal University of Viçosa, Viçosa, Brazil
241 rdf:type schema:Organization
242 https://www.grid.ac/institutes/grid.412371.2 schema:alternateName Universidade Federal do Espírito Santo
243 schema:name Department of Integrated Education of Health, Federal University of Espirito Santo, Vitória, Brazil
244 rdf:type schema:Organization
245 https://www.grid.ac/institutes/grid.413448.e schema:alternateName Instituto de Salud Carlos III
246 schema:name CIBERobn, Fisiopatología de la Obesidad y la Nutrición, Carlos III Health Institute, Madrid, Spain
247 Department of Nutrition, Food Science and Physiology; Centre for Nutrition Research, University of Navarra, c / Irunlarrea 1, 31008, Pamplona, Navarra, Spain
248 rdf:type schema:Organization
249 https://www.grid.ac/institutes/grid.482878.9 schema:alternateName IMDEA Food
250 schema:name CIBERobn, Fisiopatología de la Obesidad y la Nutrición, Carlos III Health Institute, Madrid, Spain
251 Department of Nutrition, Food Science and Physiology; Centre for Nutrition Research, University of Navarra, c / Irunlarrea 1, 31008, Pamplona, Navarra, Spain
252 IMDEA Food, Madrid, Spain
253 IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
254 rdf:type schema:Organization
255 https://www.grid.ac/institutes/grid.5924.a schema:alternateName University of Navarra
256 schema:name Department of Nutrition, Food Science and Physiology; Centre for Nutrition Research, University of Navarra, c / Irunlarrea 1, 31008, Pamplona, Navarra, Spain
257 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...