An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-06

AUTHORS

Silvia Lorente-Cebrián, André G. V. Costa, Santiago Navas-Carretero, María Zabala, Laura M. Laiglesia, J. Alfredo Martínez, María J. Moreno-Aliaga

ABSTRACT

Inflammation is involved in the pathophysiology of many chronic diseases, such as rheumatoid arthritis and neurodegenerative diseases. Several studies have evidenced important anti-inflammatory and immunomodulatory properties of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs). This review illustrates current knowledge about the efficacy of n-3 LC-PUFAs (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), particularly) in preventing and/or treating several chronic inflammatory conditions (inflammatory bowel diseases and rheumatoid arthritis) as well as their potential benefits on neurodegenerative diseases. It is well established that n-3 LC-PUFAs are substrates for synthesis of novel series of lipid mediators (e.g., resolvins, protectins, and maresins) with potent anti-inflammatory and pro-resolving properties, which have been proposed to partly mediate the protective and beneficial actions of n-3 LC-PUFAs. Here, we briefly summarize current knowledge from preclinical studies analyzing the actions of EPA- and DHA-derived resolvins and protectins on pathophysiological models of rheumatoid arthritis, Alzheimer, and irritable bowel syndrome. More... »

PAGES

341-349

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13105-015-0395-y

DOI

http://dx.doi.org/10.1007/s13105-015-0395-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034696410

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25752887


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