Epigenetic patterns of two gene promoters (TNF-α and PON) in stroke considering obesity condition and dietary intake View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-06

AUTHORS

A. M. Gómez-Uriz, E. Goyenechea, J. Campión, A. de Arce, M. T. Martinez, B. Puchau, F. I. Milagro, I. Abete, J. A. Martínez, A. Lopez de Munain

ABSTRACT

Some causal bases of stroke remain unclear, but the nutritional effects on the epigenetic regulation of different genes may be involved. The aim was to assess the impact of epigenetic processes of human tumor necrosis factor (TNF-α) and paraoxonase (PON) promoters in the susceptibility to stroke when considering body composition and dietary intake. Twenty-four patients (12 non-stroke/12 stroke) were matched by sex (12 male/12 female), age (mean 70 ± 12 years old), and BMI (12 normal-weight/12 obese; mean 28.1 ± 6.7 kg/m(2)). Blood cell DNA was isolated and DNA methylation levels of TNF-α (-186 to +349 bp) and PON (-231 to +250 bp) promoters were analyzed by the Sequenom EpiTYPER approach. Histone modifications (H3K9ac and H3K4me3) were analyzed also by chromatin immunoprecipitation in a region of TNF-α (-297 to -185). Total TNF-α promoter methylation was lower in stroke patients (p < 0.001) and showed no interaction with body composition (p = 0.807). TNF-α and PON total methylation levels correlated each other (r = 0.44; p = 0.031), especially in stroke patients (r = 0.72; p = 0.008). The +309 CpG methylation site from TNF-α promoter was related to body weight (p = 0.027) and the region containing three CpGs (from -170 to -162 bp) to the percentage of lipid intake and dietary indexes (p < 0.05) in non-stroke patients. The methylation of PON +15 and +241 CpGs was related to body weight (p = 0.021), waist circumference (p = 0.020), and energy intake (p = 0.018), whereas +214 was associated to the quality of the diet (p < 0.05) in non-stroke patients. When comparing stroke vs non-stroke patients regarding the histone modifications analyzed at TNF-α promoter, no changes were found, although a significant association was identified between circulating TNF-α level and H3K9ac with H3K4me3. TNF-α and PON promoter methylation levels could be involved in the susceptibility to stroke and obesity outcome, respectively. The dietary intake and body composition may influence this epigenetic regulation in non-stroke patients. More... »

PAGES

603-614

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13105-014-0316-5

DOI

http://dx.doi.org/10.1007/s13105-014-0316-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025759107

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24500802


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aryldialkylphosphatase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Primers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diet", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stroke", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Navarra", 
          "id": "https://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00f3mez-Uriz", 
        "givenName": "A. M.", 
        "id": "sg:person.0716366364.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716366364.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Neuroscience Area, Instituto Biodonostia Donostia, Donostia-San Sebastian, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goyenechea", 
        "givenName": "E.", 
        "id": "sg:person.01160321321.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160321321.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Salud Carlos III", 
          "id": "https://www.grid.ac/institutes/grid.413448.e", 
          "name": [
            "Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain", 
            "CIBER Fisiopatolog\u00eda Obesidad y Nutrici\u00f3n (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Campi\u00f3n", 
        "givenName": "J.", 
        "id": "sg:person.01143407230.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143407230.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Salud Carlos III", 
          "id": "https://www.grid.ac/institutes/grid.413448.e", 
          "name": [
            "Neuroscience Area, Instituto Biodonostia Donostia, Donostia-San Sebastian, Spain", 
            "Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain", 
            "Department of Neurology, Neurovascular Unit, Hospital Universitario Donostia, Donostia-San Sebastian, Spain", 
            "CIBERNED Ministry of Economy and Competitiveness, Institute Carlos III, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Arce", 
        "givenName": "A.", 
        "id": "sg:person.0632506026.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632506026.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of the Basque Country", 
          "id": "https://www.grid.ac/institutes/grid.11480.3c", 
          "name": [
            "Neuroscience Area, Instituto Biodonostia Donostia, Donostia-San Sebastian, Spain", 
            "Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain", 
            "Department of Neurology, Neurovascular Unit, Hospital Universitario Donostia, Donostia-San Sebastian, Spain", 
            "CIBERNED Ministry of Economy and Competitiveness, Institute Carlos III, Barcelona, Spain", 
            "Department of Neurosciences, University of the Basque Country UPV/EHU, San Sebasti\u00e1n, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martinez", 
        "givenName": "M. T.", 
        "id": "sg:person.01050457150.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050457150.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Navarra", 
          "id": "https://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Puchau", 
        "givenName": "B.", 
        "id": "sg:person.01233730657.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233730657.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Salud Carlos III", 
          "id": "https://www.grid.ac/institutes/grid.413448.e", 
          "name": [
            "Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain", 
            "CIBER Fisiopatolog\u00eda Obesidad y Nutrici\u00f3n (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milagro", 
        "givenName": "F. I.", 
        "id": "sg:person.01120447517.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120447517.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Neuroscience Area, Instituto Biodonostia Donostia, Donostia-San Sebastian, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abete", 
        "givenName": "I.", 
        "id": "sg:person.01341051772.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341051772.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Salud Carlos III", 
          "id": "https://www.grid.ac/institutes/grid.413448.e", 
          "name": [
            "Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain", 
            "CIBER Fisiopatolog\u00eda Obesidad y Nutrici\u00f3n (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00ednez", 
        "givenName": "J. A.", 
        "id": "sg:person.01052334317.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052334317.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of the Basque Country", 
          "id": "https://www.grid.ac/institutes/grid.11480.3c", 
          "name": [
            "Neuroscience Area, Instituto Biodonostia Donostia, Donostia-San Sebastian, Spain", 
            "Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain", 
            "Department of Neurology, Neurovascular Unit, Hospital Universitario Donostia, Donostia-San Sebastian, Spain", 
            "CIBERNED Ministry of Economy and Competitiveness, Institute Carlos III, Barcelona, Spain", 
            "Department of Neurosciences, University of the Basque Country UPV/EHU, San Sebasti\u00e1n, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopez de Munain", 
        "givenName": "A.", 
        "id": "sg:person.01163352034.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163352034.90"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.3945/ajcn.2009.28923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000383873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.108.524587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001763325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.108.524587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001763325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.111.614099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001779552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.111.614099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001779552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-8935-2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002792706", 
          "https://doi.org/10.1186/1756-8935-2-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-8935-2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002792706", 
          "https://doi.org/10.1186/1756-8935-2-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/epr.12.33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003890829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004186565", 
          "https://doi.org/10.1038/nrc1045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004186565", 
          "https://doi.org/10.1038/nrc1045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.metabol.2007.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007098009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db08-0645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007873951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd006062.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009385621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.20594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009842529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopha.2010.09.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011305890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.01.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012077445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.109.570523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012935651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.109.570523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012935651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejcn.1602833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012993559", 
          "https://doi.org/10.1038/sj.ejcn.1602833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneurol.2010.275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014523156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-375003-7.00011-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015163088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11910-009-0004-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016744120", 
          "https://doi.org/10.1007/s11910-009-0004-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m704584200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018191463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.110.580589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018209873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.110.580589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018209873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.281.12.1112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019196060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nutres.2008.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021482649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m609446200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022098690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2013.03.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023364432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1130-8621(05)71141-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025277803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2010.195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025827045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2010.195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025827045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13506120209114817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026934478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ahj.2007.02.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027263868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13311-013-0207-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028966250", 
          "https://doi.org/10.1007/s13311-013-0207-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11745-010-3393-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029118497", 
          "https://doi.org/10.1007/s11745-010-3393-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11745-010-3393-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029118497", 
          "https://doi.org/10.1007/s11745-010-3393-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(09)70262-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029345954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000205319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030420904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.109.130005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032581877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.109.130005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032581877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/mutage/geq008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033243593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/mutage/geq008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033243593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1753-4887.2009.00265.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036002401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1753-4887.2009.00265.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036002401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00534-010-0278-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039042604", 
          "https://doi.org/10.1007/s00534-010-0278-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60761-350-3_12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039214402", 
          "https://doi.org/10.1007/978-1-60761-350-3_12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60761-350-3_12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039214402", 
          "https://doi.org/10.1007/978-1-60761-350-3_12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/nen.0b013e3181af2e46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039333940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/nen.0b013e3181af2e46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039333940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0404.2007.00929.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039559414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nut.2009.06.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042427061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2012.134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042829188", 
          "https://doi.org/10.1038/npp.2012.134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3164/jcbn.09-26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045992966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3164/jcbn.09-26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045992966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2013.05.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047317391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0b013e3182009701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050811077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2008.092171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050843424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2008.679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053417764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.2151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053456536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.2151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053456536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ije/22.3.512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059675151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/187152411796011330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069220367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/org.6.1.11121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072306900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1877-1173(10)94011-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078292303"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-06", 
    "datePublishedReg": "2014-06-01", 
    "description": "Some causal bases of stroke remain unclear, but the nutritional effects on the epigenetic regulation of different genes may be involved. The aim was to assess the impact of epigenetic processes of human tumor necrosis factor (TNF-\u03b1) and paraoxonase (PON) promoters in the susceptibility to stroke when considering body composition and dietary intake. Twenty-four patients (12 non-stroke/12 stroke) were matched by sex (12 male/12 female), age (mean 70\u2009\u00b1\u200912\u00a0years old), and BMI (12 normal-weight/12 obese; mean 28.1\u2009\u00b1\u20096.7\u00a0kg/m(2)). Blood cell DNA was isolated and DNA methylation levels of TNF-\u03b1 (-186 to +349\u00a0bp) and PON (-231 to +250\u00a0bp) promoters were analyzed by the Sequenom EpiTYPER approach. Histone modifications (H3K9ac and H3K4me3) were analyzed also by chromatin immunoprecipitation in a region of TNF-\u03b1 (-297 to -185). Total TNF-\u03b1 promoter methylation was lower in stroke patients (p\u2009<\u20090.001) and showed no interaction with body composition (p\u2009=\u20090.807). TNF-\u03b1 and PON total methylation levels correlated each other (r\u2009=\u20090.44; p\u2009=\u20090.031), especially in stroke patients (r\u2009=\u20090.72; p\u2009=\u20090.008). The +309 CpG methylation site from TNF-\u03b1 promoter was related to body weight (p\u2009=\u20090.027) and the region containing three CpGs (from -170 to -162\u00a0bp) to the percentage of lipid intake and dietary indexes (p\u2009<\u20090.05) in non-stroke patients. The methylation of PON +15 and +241 CpGs was related to body weight (p\u2009=\u20090.021), waist circumference (p\u2009=\u20090.020), and energy intake (p\u2009=\u20090.018), whereas +214 was associated to the quality of the diet (p\u2009<\u20090.05) in non-stroke patients. When comparing stroke vs non-stroke patients regarding the histone modifications analyzed at TNF-\u03b1 promoter, no changes were found, although a significant association was identified between circulating TNF-\u03b1 level and H3K9ac with H3K4me3. TNF-\u03b1 and PON promoter methylation levels could be involved in the susceptibility to stroke and obesity outcome, respectively. The dietary intake and body composition may influence this epigenetic regulation in non-stroke patients. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s13105-014-0316-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018705", 
        "issn": [
          "1138-7548", 
          "1877-8755"
        ], 
        "name": "Journal of Physiology and Biochemistry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "70"
      }
    ], 
    "name": "Epigenetic patterns of two gene promoters (TNF-\u03b1 and PON) in stroke considering obesity condition and dietary intake", 
    "pagination": "603-614", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7ab8213d1bce2b91404b45fc36ef882bdd6d32f98c60cda3742d950d293d3e3e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24500802"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9812509"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13105-014-0316-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025759107"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13105-014-0316-5", 
      "https://app.dimensions.ai/details/publication/pub.1025759107"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs13105-014-0316-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13105-014-0316-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13105-014-0316-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13105-014-0316-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13105-014-0316-5'


 

This table displays all metadata directly associated to this object as RDF triples.

374 TRIPLES      21 PREDICATES      95 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13105-014-0316-5 schema:about N244544750cc5476db5e1b59e8cb47f0d
2 N256143d99a2641f7acce0a37829dde8b
3 N350727cf65db4808bc15d41bf25f88c0
4 N486b35973388438d84cfbc68d1111348
5 N4fd1fb766c0d428593fd0cc51abfc40e
6 N79df5a98096a4f2d9e38e8f000535298
7 N804a6385615c44e4a2fdbf840291bd9e
8 N816523b17f3446e78f2620e442ad10fa
9 N81e01f1bbb224b8bbd76caa82ad2ac99
10 N84ebe013d09d4e9da576fcab48cd0d71
11 Nbfe2186d29f04765a0ff5f45fc42f5a4
12 Nc2dd108676f144449c53fd5a879a5e1a
13 Ne510c8083ec5485dacb916c6d3977c7a
14 Nf350175fcc774104b136c00ebe4e8ca4
15 Nf63a4775e0b641f8bb6fdf4a3cd02efc
16 Nfd02722d39484ddbb1e8182d95b76cfc
17 anzsrc-for:06
18 anzsrc-for:0604
19 schema:author Nef75c4451f724ea2af25a9fecd8576c8
20 schema:citation sg:pub.10.1007/978-1-60761-350-3_12
21 sg:pub.10.1007/s00534-010-0278-0
22 sg:pub.10.1007/s11745-010-3393-4
23 sg:pub.10.1007/s11910-009-0004-y
24 sg:pub.10.1007/s13311-013-0207-4
25 sg:pub.10.1038/npp.2012.134
26 sg:pub.10.1038/nrc1045
27 sg:pub.10.1038/sj.ejcn.1602833
28 sg:pub.10.1186/1756-8935-2-3
29 https://doi.org/10.1001/archneurol.2010.275
30 https://doi.org/10.1001/jama.281.12.1112
31 https://doi.org/10.1002/14651858.cd006062.pub2
32 https://doi.org/10.1002/humu.20594
33 https://doi.org/10.1002/sim.2151
34 https://doi.org/10.1016/b978-0-12-375003-7.00011-x
35 https://doi.org/10.1016/j.ahj.2007.02.031
36 https://doi.org/10.1016/j.biopha.2010.09.017
37 https://doi.org/10.1016/j.cell.2007.01.023
38 https://doi.org/10.1016/j.cyto.2013.05.028
39 https://doi.org/10.1016/j.jacc.2013.03.031
40 https://doi.org/10.1016/j.metabol.2007.07.005
41 https://doi.org/10.1016/j.nut.2009.06.017
42 https://doi.org/10.1016/j.nutres.2008.11.003
43 https://doi.org/10.1016/s1130-8621(05)71141-4
44 https://doi.org/10.1016/s1474-4422(09)70262-5
45 https://doi.org/10.1016/s1877-1173(10)94011-8
46 https://doi.org/10.1038/jcbfm.2010.195
47 https://doi.org/10.1038/oby.2008.679
48 https://doi.org/10.1074/jbc.m609446200
49 https://doi.org/10.1074/jbc.m704584200
50 https://doi.org/10.1093/ije/22.3.512
51 https://doi.org/10.1093/mutage/geq008
52 https://doi.org/10.1097/nen.0b013e3181af2e46
53 https://doi.org/10.1111/j.1600-0404.2007.00929.x
54 https://doi.org/10.1111/j.1753-4887.2009.00265.x
55 https://doi.org/10.1136/ard.2008.092171
56 https://doi.org/10.1159/000205319
57 https://doi.org/10.1161/cir.0b013e3182009701
58 https://doi.org/10.1161/hypertensionaha.109.130005
59 https://doi.org/10.1161/strokeaha.108.524587
60 https://doi.org/10.1161/strokeaha.109.570523
61 https://doi.org/10.1161/strokeaha.110.580589
62 https://doi.org/10.1161/strokeaha.111.614099
63 https://doi.org/10.1586/epr.12.33
64 https://doi.org/10.2174/187152411796011330
65 https://doi.org/10.2337/db08-0645
66 https://doi.org/10.3109/13506120209114817
67 https://doi.org/10.3164/jcbn.09-26
68 https://doi.org/10.3945/ajcn.2009.28923
69 https://doi.org/10.4161/org.6.1.11121
70 schema:datePublished 2014-06
71 schema:datePublishedReg 2014-06-01
72 schema:description Some causal bases of stroke remain unclear, but the nutritional effects on the epigenetic regulation of different genes may be involved. The aim was to assess the impact of epigenetic processes of human tumor necrosis factor (TNF-α) and paraoxonase (PON) promoters in the susceptibility to stroke when considering body composition and dietary intake. Twenty-four patients (12 non-stroke/12 stroke) were matched by sex (12 male/12 female), age (mean 70 ± 12 years old), and BMI (12 normal-weight/12 obese; mean 28.1 ± 6.7 kg/m(2)). Blood cell DNA was isolated and DNA methylation levels of TNF-α (-186 to +349 bp) and PON (-231 to +250 bp) promoters were analyzed by the Sequenom EpiTYPER approach. Histone modifications (H3K9ac and H3K4me3) were analyzed also by chromatin immunoprecipitation in a region of TNF-α (-297 to -185). Total TNF-α promoter methylation was lower in stroke patients (p < 0.001) and showed no interaction with body composition (p = 0.807). TNF-α and PON total methylation levels correlated each other (r = 0.44; p = 0.031), especially in stroke patients (r = 0.72; p = 0.008). The +309 CpG methylation site from TNF-α promoter was related to body weight (p = 0.027) and the region containing three CpGs (from -170 to -162 bp) to the percentage of lipid intake and dietary indexes (p < 0.05) in non-stroke patients. The methylation of PON +15 and +241 CpGs was related to body weight (p = 0.021), waist circumference (p = 0.020), and energy intake (p = 0.018), whereas +214 was associated to the quality of the diet (p < 0.05) in non-stroke patients. When comparing stroke vs non-stroke patients regarding the histone modifications analyzed at TNF-α promoter, no changes were found, although a significant association was identified between circulating TNF-α level and H3K9ac with H3K4me3. TNF-α and PON promoter methylation levels could be involved in the susceptibility to stroke and obesity outcome, respectively. The dietary intake and body composition may influence this epigenetic regulation in non-stroke patients.
73 schema:genre research_article
74 schema:inLanguage en
75 schema:isAccessibleForFree false
76 schema:isPartOf Nc4b4ac2c7ea24127ab3905eb5b52047b
77 Nf37343dbbca34ed3b68c7e342f5cac1f
78 sg:journal.1018705
79 schema:name Epigenetic patterns of two gene promoters (TNF-α and PON) in stroke considering obesity condition and dietary intake
80 schema:pagination 603-614
81 schema:productId N40684be4ca3c448b925e0f730e5f2dcf
82 N98e1479130b647c2a57be9957bc59ff4
83 Ne9666fc818cb43c98c07dc616dffdd4c
84 Nf665863d6a544e33b07f3849f03ecf97
85 Nfc841c6069354e69a372627ef1a59ba0
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025759107
87 https://doi.org/10.1007/s13105-014-0316-5
88 schema:sdDatePublished 2019-04-11T02:08
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N4010de1f15b64d86b88b29e1aa5f0f66
91 schema:url http://link.springer.com/10.1007%2Fs13105-014-0316-5
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N0f6a5405e17b4efba2e8336ee6f0e0b3 rdf:first sg:person.01163352034.90
96 rdf:rest rdf:nil
97 N21992aca8d5d452aa8df810c2f0e251d rdf:first sg:person.01050457150.08
98 rdf:rest N675da2b56b314a9aaab188e2e79effec
99 N244544750cc5476db5e1b59e8cb47f0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Male
101 rdf:type schema:DefinedTerm
102 N256143d99a2641f7acce0a37829dde8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name DNA Methylation
104 rdf:type schema:DefinedTerm
105 N2aae7f5a3b0548e394baacb480044d4a schema:name Neuroscience Area, Instituto Biodonostia Donostia, Donostia-San Sebastian, Spain
106 rdf:type schema:Organization
107 N34d124bc78774786951ec8ba085d191d rdf:first sg:person.01052334317.42
108 rdf:rest N0f6a5405e17b4efba2e8336ee6f0e0b3
109 N350727cf65db4808bc15d41bf25f88c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Promoter Regions, Genetic
111 rdf:type schema:DefinedTerm
112 N36befb74467344008e9227a85860e84c schema:name Neuroscience Area, Instituto Biodonostia Donostia, Donostia-San Sebastian, Spain
113 rdf:type schema:Organization
114 N4010de1f15b64d86b88b29e1aa5f0f66 schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 N40684be4ca3c448b925e0f730e5f2dcf schema:name dimensions_id
117 schema:value pub.1025759107
118 rdf:type schema:PropertyValue
119 N47dc0c1f9952479db2d90587b603815b rdf:first sg:person.0632506026.24
120 rdf:rest N21992aca8d5d452aa8df810c2f0e251d
121 N486b35973388438d84cfbc68d1111348 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Tumor Necrosis Factor-alpha
123 rdf:type schema:DefinedTerm
124 N4fd1fb766c0d428593fd0cc51abfc40e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Diet
126 rdf:type schema:DefinedTerm
127 N5483f127c8b34e729b65c911c4ea059c rdf:first sg:person.01120447517.99
128 rdf:rest N9269ffafceb54e42b1b2b9b68140a0b3
129 N675da2b56b314a9aaab188e2e79effec rdf:first sg:person.01233730657.37
130 rdf:rest N5483f127c8b34e729b65c911c4ea059c
131 N67d20ae0a08a48bf91eee14fcca5b660 rdf:first sg:person.01143407230.73
132 rdf:rest N47dc0c1f9952479db2d90587b603815b
133 N6aadd3dd2d3b40169e46d89780770741 rdf:first sg:person.01160321321.23
134 rdf:rest N67d20ae0a08a48bf91eee14fcca5b660
135 N79df5a98096a4f2d9e38e8f000535298 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Aryldialkylphosphatase
137 rdf:type schema:DefinedTerm
138 N804a6385615c44e4a2fdbf840291bd9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Obesity
140 rdf:type schema:DefinedTerm
141 N816523b17f3446e78f2620e442ad10fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Epigenesis, Genetic
143 rdf:type schema:DefinedTerm
144 N81e01f1bbb224b8bbd76caa82ad2ac99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Stroke
146 rdf:type schema:DefinedTerm
147 N84ebe013d09d4e9da576fcab48cd0d71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name DNA Primers
149 rdf:type schema:DefinedTerm
150 N9269ffafceb54e42b1b2b9b68140a0b3 rdf:first sg:person.01341051772.85
151 rdf:rest N34d124bc78774786951ec8ba085d191d
152 N98e1479130b647c2a57be9957bc59ff4 schema:name pubmed_id
153 schema:value 24500802
154 rdf:type schema:PropertyValue
155 Nbfe2186d29f04765a0ff5f45fc42f5a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Humans
157 rdf:type schema:DefinedTerm
158 Nc2dd108676f144449c53fd5a879a5e1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Aged
160 rdf:type schema:DefinedTerm
161 Nc4b4ac2c7ea24127ab3905eb5b52047b schema:volumeNumber 70
162 rdf:type schema:PublicationVolume
163 Ne510c8083ec5485dacb916c6d3977c7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Base Sequence
165 rdf:type schema:DefinedTerm
166 Ne9666fc818cb43c98c07dc616dffdd4c schema:name readcube_id
167 schema:value 7ab8213d1bce2b91404b45fc36ef882bdd6d32f98c60cda3742d950d293d3e3e
168 rdf:type schema:PropertyValue
169 Nef75c4451f724ea2af25a9fecd8576c8 rdf:first sg:person.0716366364.39
170 rdf:rest N6aadd3dd2d3b40169e46d89780770741
171 Nf350175fcc774104b136c00ebe4e8ca4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Female
173 rdf:type schema:DefinedTerm
174 Nf37343dbbca34ed3b68c7e342f5cac1f schema:issueNumber 2
175 rdf:type schema:PublicationIssue
176 Nf63a4775e0b641f8bb6fdf4a3cd02efc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Middle Aged
178 rdf:type schema:DefinedTerm
179 Nf665863d6a544e33b07f3849f03ecf97 schema:name doi
180 schema:value 10.1007/s13105-014-0316-5
181 rdf:type schema:PropertyValue
182 Nfc841c6069354e69a372627ef1a59ba0 schema:name nlm_unique_id
183 schema:value 9812509
184 rdf:type schema:PropertyValue
185 Nfd02722d39484ddbb1e8182d95b76cfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Real-Time Polymerase Chain Reaction
187 rdf:type schema:DefinedTerm
188 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
189 schema:name Biological Sciences
190 rdf:type schema:DefinedTerm
191 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
192 schema:name Genetics
193 rdf:type schema:DefinedTerm
194 sg:journal.1018705 schema:issn 1138-7548
195 1877-8755
196 schema:name Journal of Physiology and Biochemistry
197 rdf:type schema:Periodical
198 sg:person.01050457150.08 schema:affiliation https://www.grid.ac/institutes/grid.11480.3c
199 schema:familyName Martinez
200 schema:givenName M. T.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050457150.08
202 rdf:type schema:Person
203 sg:person.01052334317.42 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
204 schema:familyName Martínez
205 schema:givenName J. A.
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052334317.42
207 rdf:type schema:Person
208 sg:person.01120447517.99 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
209 schema:familyName Milagro
210 schema:givenName F. I.
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120447517.99
212 rdf:type schema:Person
213 sg:person.01143407230.73 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
214 schema:familyName Campión
215 schema:givenName J.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143407230.73
217 rdf:type schema:Person
218 sg:person.01160321321.23 schema:affiliation N36befb74467344008e9227a85860e84c
219 schema:familyName Goyenechea
220 schema:givenName E.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160321321.23
222 rdf:type schema:Person
223 sg:person.01163352034.90 schema:affiliation https://www.grid.ac/institutes/grid.11480.3c
224 schema:familyName Lopez de Munain
225 schema:givenName A.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163352034.90
227 rdf:type schema:Person
228 sg:person.01233730657.37 schema:affiliation https://www.grid.ac/institutes/grid.5924.a
229 schema:familyName Puchau
230 schema:givenName B.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233730657.37
232 rdf:type schema:Person
233 sg:person.01341051772.85 schema:affiliation N2aae7f5a3b0548e394baacb480044d4a
234 schema:familyName Abete
235 schema:givenName I.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341051772.85
237 rdf:type schema:Person
238 sg:person.0632506026.24 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
239 schema:familyName de Arce
240 schema:givenName A.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632506026.24
242 rdf:type schema:Person
243 sg:person.0716366364.39 schema:affiliation https://www.grid.ac/institutes/grid.5924.a
244 schema:familyName Gómez-Uriz
245 schema:givenName A. M.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716366364.39
247 rdf:type schema:Person
248 sg:pub.10.1007/978-1-60761-350-3_12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039214402
249 https://doi.org/10.1007/978-1-60761-350-3_12
250 rdf:type schema:CreativeWork
251 sg:pub.10.1007/s00534-010-0278-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039042604
252 https://doi.org/10.1007/s00534-010-0278-0
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/s11745-010-3393-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029118497
255 https://doi.org/10.1007/s11745-010-3393-4
256 rdf:type schema:CreativeWork
257 sg:pub.10.1007/s11910-009-0004-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1016744120
258 https://doi.org/10.1007/s11910-009-0004-y
259 rdf:type schema:CreativeWork
260 sg:pub.10.1007/s13311-013-0207-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028966250
261 https://doi.org/10.1007/s13311-013-0207-4
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/npp.2012.134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042829188
264 https://doi.org/10.1038/npp.2012.134
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/nrc1045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004186565
267 https://doi.org/10.1038/nrc1045
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/sj.ejcn.1602833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012993559
270 https://doi.org/10.1038/sj.ejcn.1602833
271 rdf:type schema:CreativeWork
272 sg:pub.10.1186/1756-8935-2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002792706
273 https://doi.org/10.1186/1756-8935-2-3
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1001/archneurol.2010.275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014523156
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1001/jama.281.12.1112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019196060
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1002/14651858.cd006062.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009385621
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1002/humu.20594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009842529
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1002/sim.2151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053456536
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/b978-0-12-375003-7.00011-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015163088
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.ahj.2007.02.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027263868
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.biopha.2010.09.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011305890
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.cell.2007.01.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012077445
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.cyto.2013.05.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047317391
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.jacc.2013.03.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023364432
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.metabol.2007.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007098009
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.nut.2009.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042427061
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.nutres.2008.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021482649
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/s1130-8621(05)71141-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025277803
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/s1474-4422(09)70262-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029345954
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/s1877-1173(10)94011-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078292303
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1038/jcbfm.2010.195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025827045
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1038/oby.2008.679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053417764
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1074/jbc.m609446200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022098690
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1074/jbc.m704584200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018191463
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1093/ije/22.3.512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059675151
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1093/mutage/geq008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033243593
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1097/nen.0b013e3181af2e46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039333940
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1111/j.1600-0404.2007.00929.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039559414
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1111/j.1753-4887.2009.00265.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036002401
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1136/ard.2008.092171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050843424
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1159/000205319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030420904
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1161/cir.0b013e3182009701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050811077
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1161/hypertensionaha.109.130005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032581877
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1161/strokeaha.108.524587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001763325
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1161/strokeaha.109.570523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012935651
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1161/strokeaha.110.580589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018209873
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1161/strokeaha.111.614099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001779552
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1586/epr.12.33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003890829
344 rdf:type schema:CreativeWork
345 https://doi.org/10.2174/187152411796011330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069220367
346 rdf:type schema:CreativeWork
347 https://doi.org/10.2337/db08-0645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007873951
348 rdf:type schema:CreativeWork
349 https://doi.org/10.3109/13506120209114817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026934478
350 rdf:type schema:CreativeWork
351 https://doi.org/10.3164/jcbn.09-26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045992966
352 rdf:type schema:CreativeWork
353 https://doi.org/10.3945/ajcn.2009.28923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000383873
354 rdf:type schema:CreativeWork
355 https://doi.org/10.4161/org.6.1.11121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072306900
356 rdf:type schema:CreativeWork
357 https://www.grid.ac/institutes/grid.11480.3c schema:alternateName University of the Basque Country
358 schema:name CIBERNED Ministry of Economy and Competitiveness, Institute Carlos III, Barcelona, Spain
359 Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain
360 Department of Neurology, Neurovascular Unit, Hospital Universitario Donostia, Donostia-San Sebastian, Spain
361 Department of Neurosciences, University of the Basque Country UPV/EHU, San Sebastián, Spain
362 Neuroscience Area, Instituto Biodonostia Donostia, Donostia-San Sebastian, Spain
363 rdf:type schema:Organization
364 https://www.grid.ac/institutes/grid.413448.e schema:alternateName Instituto de Salud Carlos III
365 schema:name CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain
366 CIBERNED Ministry of Economy and Competitiveness, Institute Carlos III, Barcelona, Spain
367 Department of Neurology, Hospital Universitario Donostia, Donostia-San Sebastian, Spain
368 Department of Neurology, Neurovascular Unit, Hospital Universitario Donostia, Donostia-San Sebastian, Spain
369 Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain
370 Neuroscience Area, Instituto Biodonostia Donostia, Donostia-San Sebastian, Spain
371 rdf:type schema:Organization
372 https://www.grid.ac/institutes/grid.5924.a schema:alternateName University of Navarra
373 schema:name Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain
374 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...