Proteinuria Predicts Resistance to Antiplatelet Therapy in Ischemic Stroke View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-04

AUTHORS

Gemlyn George, Nikul Patel, Cecilia Jang, David Wheeler, Sridhara S. Yaddanapudi, Jonathan Dissin, Ramani Balu, Janani Rangaswami

ABSTRACT

The occurrence of a stroke while on antiplatelet agents presents a therapeutic dilemma. One of the main causes for recurrent strokes is antiplatelet resistance more commonly known as high on treatment platelet reactivity (HTPR). Prior studies have established that proteinuria is associated with HTPR following myocardial infarction. Here, we investigated whether dipstick proteinuria correlates with HTPR in patients presenting with stroke. We performed a retrospective cohort analysis of 102 patients admitted for a recurrent ischemic stroke that had either a VerifyNow aspirin or VerifyNow clopidogrel laboratory test performed to assess platelet reactivity. Dipstick proteinuria was defined as > 30 mg/dl (2+ or more). HTPR was defined as an aspirin resistance unit > 550 for aspirin and a P2Y12 reactivity unit > 208 for clopidogrel. Patients with proteinuria on dipstick were significantly more likely to have HTPR to either aspirin (p value 0.017) or clopidogrel (p value 0.017). After controlling for age, smoking, diabetes, hypertension, CAD and GFR, proteinuria was an independent predictor of HTPR for patient taking aspirin (p = 0.025). Platelet resistance is an entity that undermines the activity of antiplatelet agents in reducing stroke risk. Here, we demonstrate an association with increased platelet reactivity and proteinuria. This highlights a potential new therapeutic target in reducing future stroke risk. More... »

PAGES

130-134

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12975-017-0568-9

DOI

http://dx.doi.org/10.1007/s12975-017-0568-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091492410

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28875481


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Ischemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Aggregation Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteinuria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stroke", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Albert Einstein Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239276.b", 
          "name": [
            "Department of Internal Medicine, Einstein Medical Center, Klein 303, 5501 Old York Road, 19141, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "George", 
        "givenName": "Gemlyn", 
        "id": "sg:person.01146456721.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146456721.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239276.b", 
          "name": [
            "Department of Internal Medicine, Einstein Medical Center, Klein 303, 5501 Old York Road, 19141, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Patel", 
        "givenName": "Nikul", 
        "id": "sg:person.01134626221.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134626221.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239276.b", 
          "name": [
            "Department of Internal Medicine, Einstein Medical Center, Klein 303, 5501 Old York Road, 19141, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jang", 
        "givenName": "Cecilia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239276.b", 
          "name": [
            "Department of Internal Medicine, Einstein Medical Center, Klein 303, 5501 Old York Road, 19141, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wheeler", 
        "givenName": "David", 
        "id": "sg:person.01061677203.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061677203.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239276.b", 
          "name": [
            "Department of Neurosciences, Einstein Medical Center, 5501 Old York Road, 19141, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yaddanapudi", 
        "givenName": "Sridhara S.", 
        "id": "sg:person.016375111777.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016375111777.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239276.b", 
          "name": [
            "Department of Neurosciences, Einstein Medical Center, 5501 Old York Road, 19141, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dissin", 
        "givenName": "Jonathan", 
        "id": "sg:person.0107303376.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0107303376.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital of the University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.411115.1", 
          "name": [
            "Division of Neurocritical Care, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA", 
            "Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Balu", 
        "givenName": "Ramani", 
        "id": "sg:person.013547260757.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013547260757.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thomas Jefferson University", 
          "id": "https://www.grid.ac/institutes/grid.265008.9", 
          "name": [
            "Department of Internal Medicine, Einstein Medical Center, Klein 303, 5501 Old York Road, 19141, Philadelphia, PA, USA", 
            "Sidney Kimmel College of Thomas Jefferson University, Philadelphia, PA, USA", 
            "Delaware Valley Nephrology Associates, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rangaswami", 
        "givenName": "Janani", 
        "id": "sg:person.01045604242.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045604242.84"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.amjcard.2008.11.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000329979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(06)68040-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001808729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200109203451215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004072321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/ern.10.203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005418593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.110.602615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011636085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.110.602615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011636085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000162719.11058.bd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011877351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000162719.11058.bd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011877351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaneurol.2013.601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012614713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneph.2013.197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015192200", 
          "https://doi.org/10.1038/nrneph.2013.197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.115.009861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015429132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.115.009861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015429132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneph.2015.162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016575990", 
          "https://doi.org/10.1038/nrneph.2015.162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000315147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017184472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11239-006-9043-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020581792", 
          "https://doi.org/10.1007/s11239-006-9043-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2215/cjn.03500412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022282163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.39430.529549.be", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026126962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00533.2014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033655336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/09537104.2014.971000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034210981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.07.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034462704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/hr.2015.69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039037242", 
          "https://doi.org/10.1038/hr.2015.69"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000001560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041925599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000001560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041925599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0049-3848(93)90164-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048337277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ahj.2006.10.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051295519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0000000000000485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079401866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0000000000000485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079401866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0000000000000485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079401866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083166055", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-04", 
    "datePublishedReg": "2018-04-01", 
    "description": "The occurrence of a stroke while on antiplatelet agents presents a therapeutic dilemma. One of the main causes for recurrent strokes is antiplatelet resistance more commonly known as high on treatment platelet reactivity (HTPR). Prior studies have established that proteinuria is associated with HTPR following myocardial infarction. Here, we investigated whether dipstick proteinuria correlates with HTPR in patients presenting with stroke. We performed a retrospective cohort analysis of 102 patients admitted for a recurrent ischemic stroke that had either a VerifyNow aspirin or VerifyNow clopidogrel laboratory test performed to assess platelet reactivity. Dipstick proteinuria was defined as >\u00a030\u00a0mg/dl (2+ or more). HTPR was defined as an aspirin resistance unit >\u00a0550 for aspirin and a P2Y12 reactivity unit >\u00a0208 for clopidogrel. Patients with proteinuria on dipstick were significantly more likely to have HTPR to either aspirin (p value 0.017) or clopidogrel (p value 0.017). After controlling for age, smoking, diabetes, hypertension, CAD and GFR, proteinuria was an independent predictor of HTPR for patient taking aspirin (p\u00a0=\u00a00.025). Platelet resistance is an entity that undermines the activity of antiplatelet agents in reducing stroke risk. Here, we demonstrate an association with increased platelet reactivity and proteinuria. This highlights a potential new therapeutic target in reducing future stroke risk.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12975-017-0568-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1042288", 
        "issn": [
          "1868-4483", 
          "1868-601X"
        ], 
        "name": "Translational Stroke Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Proteinuria Predicts Resistance to Antiplatelet Therapy in Ischemic Stroke", 
    "pagination": "130-134", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5e661ebb946ed2a2eccad1436172892bb9de0109c5d5b17e88d9b15b9bacc7af"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28875481"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101517297"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12975-017-0568-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091492410"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12975-017-0568-9", 
      "https://app.dimensions.ai/details/publication/pub.1091492410"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000563.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s12975-017-0568-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12975-017-0568-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12975-017-0568-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12975-017-0568-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12975-017-0568-9'


 

This table displays all metadata directly associated to this object as RDF triples.

247 TRIPLES      21 PREDICATES      64 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12975-017-0568-9 schema:about N48f9113b456548e38596cdf6b7ea522b
2 N5702e8e4806e459eaeb9b0bc60985f52
3 N60efc3116c8b437ab8191fc4eb3bbc65
4 N67f2be4e76b34f488c9d95a7ec59aa1f
5 N7c68cc83447e402aa2074afaabfb21c9
6 N8b4954d6a60d4666873bd04541459fdd
7 N991ed7f5c89540e1a7ad7f3185b35ba0
8 Nb5ec8151298a44049ebf25dd90f5539a
9 Nbd03ded78edb499da4046d0a3d842e97
10 Nbf42b9100a22439987911f479105c9fa
11 Ndb22a4c765da4770ad1b100fc978b745
12 Ndbf5fd363e4b4255b2bf3f66d0f2ec3d
13 anzsrc-for:11
14 anzsrc-for:1103
15 schema:author Na75f3796741044eab4ebc81b2bd89a3e
16 schema:citation sg:pub.10.1007/s11239-006-9043-2
17 sg:pub.10.1038/hr.2015.69
18 sg:pub.10.1038/nrneph.2013.197
19 sg:pub.10.1038/nrneph.2015.162
20 https://app.dimensions.ai/details/publication/pub.1083166055
21 https://doi.org/10.1001/jamaneurol.2013.601
22 https://doi.org/10.1016/0049-3848(93)90164-j
23 https://doi.org/10.1016/j.ahj.2006.10.040
24 https://doi.org/10.1016/j.amjcard.2008.11.019
25 https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.07.012
26 https://doi.org/10.1016/s0140-6736(06)68040-9
27 https://doi.org/10.1056/nejm200109203451215
28 https://doi.org/10.1097/md.0000000000001560
29 https://doi.org/10.1136/bmj.39430.529549.be
30 https://doi.org/10.1152/ajprenal.00533.2014
31 https://doi.org/10.1159/000315147
32 https://doi.org/10.1161/01.str.0000162719.11058.bd
33 https://doi.org/10.1161/cir.0000000000000485
34 https://doi.org/10.1161/strokeaha.110.602615
35 https://doi.org/10.1161/strokeaha.115.009861
36 https://doi.org/10.1586/ern.10.203
37 https://doi.org/10.2215/cjn.03500412
38 https://doi.org/10.3109/09537104.2014.971000
39 schema:datePublished 2018-04
40 schema:datePublishedReg 2018-04-01
41 schema:description The occurrence of a stroke while on antiplatelet agents presents a therapeutic dilemma. One of the main causes for recurrent strokes is antiplatelet resistance more commonly known as high on treatment platelet reactivity (HTPR). Prior studies have established that proteinuria is associated with HTPR following myocardial infarction. Here, we investigated whether dipstick proteinuria correlates with HTPR in patients presenting with stroke. We performed a retrospective cohort analysis of 102 patients admitted for a recurrent ischemic stroke that had either a VerifyNow aspirin or VerifyNow clopidogrel laboratory test performed to assess platelet reactivity. Dipstick proteinuria was defined as > 30 mg/dl (2+ or more). HTPR was defined as an aspirin resistance unit > 550 for aspirin and a P2Y12 reactivity unit > 208 for clopidogrel. Patients with proteinuria on dipstick were significantly more likely to have HTPR to either aspirin (p value 0.017) or clopidogrel (p value 0.017). After controlling for age, smoking, diabetes, hypertension, CAD and GFR, proteinuria was an independent predictor of HTPR for patient taking aspirin (p = 0.025). Platelet resistance is an entity that undermines the activity of antiplatelet agents in reducing stroke risk. Here, we demonstrate an association with increased platelet reactivity and proteinuria. This highlights a potential new therapeutic target in reducing future stroke risk.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree false
45 schema:isPartOf N2bf0479de16f41f59e7b00ba9b158a99
46 Nc851f1a7bd844362a929d81ef415c2a1
47 sg:journal.1042288
48 schema:name Proteinuria Predicts Resistance to Antiplatelet Therapy in Ischemic Stroke
49 schema:pagination 130-134
50 schema:productId N9b7b4820ecfc46dcb48f7676c3bbb142
51 Nae23c26fde7f41f9a3f49156e0c47bc3
52 Nccbf8672f5294453836ef518de315d98
53 Nd272b946fb9f43c8a33d243cc71b60da
54 Ne0de3c6f0833475781bf52cc1cf2e7ae
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091492410
56 https://doi.org/10.1007/s12975-017-0568-9
57 schema:sdDatePublished 2019-04-10T21:46
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N9a913f568d564006815d4235ea0b75f8
60 schema:url http://link.springer.com/10.1007/s12975-017-0568-9
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N2bf0479de16f41f59e7b00ba9b158a99 schema:issueNumber 2
65 rdf:type schema:PublicationIssue
66 N2f8202fb88f143b3b6066370a51dc0b0 rdf:first sg:person.01061677203.99
67 rdf:rest Nadee375816a44721a49fbe8a0e04afa7
68 N48f9113b456548e38596cdf6b7ea522b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Proteinuria
70 rdf:type schema:DefinedTerm
71 N5702e8e4806e459eaeb9b0bc60985f52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Male
73 rdf:type schema:DefinedTerm
74 N5bc1196aa0fe4bdb81672e32094b6776 schema:affiliation https://www.grid.ac/institutes/grid.239276.b
75 schema:familyName Jang
76 schema:givenName Cecilia
77 rdf:type schema:Person
78 N60efc3116c8b437ab8191fc4eb3bbc65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Platelet Aggregation Inhibitors
80 rdf:type schema:DefinedTerm
81 N67f2be4e76b34f488c9d95a7ec59aa1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Recurrence
83 rdf:type schema:DefinedTerm
84 N7c68cc83447e402aa2074afaabfb21c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Female
86 rdf:type schema:DefinedTerm
87 N8b4954d6a60d4666873bd04541459fdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Predictive Value of Tests
89 rdf:type schema:DefinedTerm
90 N991ed7f5c89540e1a7ad7f3185b35ba0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Middle Aged
92 rdf:type schema:DefinedTerm
93 N9a913f568d564006815d4235ea0b75f8 schema:name Springer Nature - SN SciGraph project
94 rdf:type schema:Organization
95 N9b7b4820ecfc46dcb48f7676c3bbb142 schema:name doi
96 schema:value 10.1007/s12975-017-0568-9
97 rdf:type schema:PropertyValue
98 Na75f3796741044eab4ebc81b2bd89a3e rdf:first sg:person.01146456721.79
99 rdf:rest Nd9aa974d8e6241db8ae155b826872a69
100 Nadee375816a44721a49fbe8a0e04afa7 rdf:first sg:person.016375111777.58
101 rdf:rest Nb0a6b73ec1ca4537b6a53f4969a0f8f5
102 Nae23c26fde7f41f9a3f49156e0c47bc3 schema:name pubmed_id
103 schema:value 28875481
104 rdf:type schema:PropertyValue
105 Nb0a6b73ec1ca4537b6a53f4969a0f8f5 rdf:first sg:person.0107303376.34
106 rdf:rest Nfa60fa49d2d94568b8e3f6c1646957c8
107 Nb5ec8151298a44049ebf25dd90f5539a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Stroke
109 rdf:type schema:DefinedTerm
110 Nb94f264185524f90b5f9b708de8cba53 rdf:first sg:person.01045604242.84
111 rdf:rest rdf:nil
112 Nbd03ded78edb499da4046d0a3d842e97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Brain Ischemia
114 rdf:type schema:DefinedTerm
115 Nbf42b9100a22439987911f479105c9fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Humans
117 rdf:type schema:DefinedTerm
118 Nc14c8f68903d4b4a8ac711d70a901a97 rdf:first N5bc1196aa0fe4bdb81672e32094b6776
119 rdf:rest N2f8202fb88f143b3b6066370a51dc0b0
120 Nc851f1a7bd844362a929d81ef415c2a1 schema:volumeNumber 9
121 rdf:type schema:PublicationVolume
122 Nccbf8672f5294453836ef518de315d98 schema:name readcube_id
123 schema:value 5e661ebb946ed2a2eccad1436172892bb9de0109c5d5b17e88d9b15b9bacc7af
124 rdf:type schema:PropertyValue
125 Nd272b946fb9f43c8a33d243cc71b60da schema:name nlm_unique_id
126 schema:value 101517297
127 rdf:type schema:PropertyValue
128 Nd9aa974d8e6241db8ae155b826872a69 rdf:first sg:person.01134626221.24
129 rdf:rest Nc14c8f68903d4b4a8ac711d70a901a97
130 Ndb22a4c765da4770ad1b100fc978b745 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Cohort Studies
132 rdf:type schema:DefinedTerm
133 Ndbf5fd363e4b4255b2bf3f66d0f2ec3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Aged
135 rdf:type schema:DefinedTerm
136 Ne0de3c6f0833475781bf52cc1cf2e7ae schema:name dimensions_id
137 schema:value pub.1091492410
138 rdf:type schema:PropertyValue
139 Nfa60fa49d2d94568b8e3f6c1646957c8 rdf:first sg:person.013547260757.63
140 rdf:rest Nb94f264185524f90b5f9b708de8cba53
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
145 schema:name Clinical Sciences
146 rdf:type schema:DefinedTerm
147 sg:journal.1042288 schema:issn 1868-4483
148 1868-601X
149 schema:name Translational Stroke Research
150 rdf:type schema:Periodical
151 sg:person.01045604242.84 schema:affiliation https://www.grid.ac/institutes/grid.265008.9
152 schema:familyName Rangaswami
153 schema:givenName Janani
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045604242.84
155 rdf:type schema:Person
156 sg:person.01061677203.99 schema:affiliation https://www.grid.ac/institutes/grid.239276.b
157 schema:familyName Wheeler
158 schema:givenName David
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061677203.99
160 rdf:type schema:Person
161 sg:person.0107303376.34 schema:affiliation https://www.grid.ac/institutes/grid.239276.b
162 schema:familyName Dissin
163 schema:givenName Jonathan
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0107303376.34
165 rdf:type schema:Person
166 sg:person.01134626221.24 schema:affiliation https://www.grid.ac/institutes/grid.239276.b
167 schema:familyName Patel
168 schema:givenName Nikul
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134626221.24
170 rdf:type schema:Person
171 sg:person.01146456721.79 schema:affiliation https://www.grid.ac/institutes/grid.239276.b
172 schema:familyName George
173 schema:givenName Gemlyn
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146456721.79
175 rdf:type schema:Person
176 sg:person.013547260757.63 schema:affiliation https://www.grid.ac/institutes/grid.411115.1
177 schema:familyName Balu
178 schema:givenName Ramani
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013547260757.63
180 rdf:type schema:Person
181 sg:person.016375111777.58 schema:affiliation https://www.grid.ac/institutes/grid.239276.b
182 schema:familyName Yaddanapudi
183 schema:givenName Sridhara S.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016375111777.58
185 rdf:type schema:Person
186 sg:pub.10.1007/s11239-006-9043-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020581792
187 https://doi.org/10.1007/s11239-006-9043-2
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/hr.2015.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039037242
190 https://doi.org/10.1038/hr.2015.69
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/nrneph.2013.197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015192200
193 https://doi.org/10.1038/nrneph.2013.197
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/nrneph.2015.162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016575990
196 https://doi.org/10.1038/nrneph.2015.162
197 rdf:type schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1083166055 schema:CreativeWork
199 https://doi.org/10.1001/jamaneurol.2013.601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012614713
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/0049-3848(93)90164-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1048337277
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.ahj.2006.10.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051295519
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.amjcard.2008.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000329979
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034462704
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/s0140-6736(06)68040-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001808729
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1056/nejm200109203451215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004072321
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1097/md.0000000000001560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041925599
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1136/bmj.39430.529549.be schema:sameAs https://app.dimensions.ai/details/publication/pub.1026126962
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1152/ajprenal.00533.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033655336
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1159/000315147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017184472
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1161/01.str.0000162719.11058.bd schema:sameAs https://app.dimensions.ai/details/publication/pub.1011877351
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1161/cir.0000000000000485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079401866
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1161/strokeaha.110.602615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011636085
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1161/strokeaha.115.009861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015429132
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1586/ern.10.203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005418593
230 rdf:type schema:CreativeWork
231 https://doi.org/10.2215/cjn.03500412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022282163
232 rdf:type schema:CreativeWork
233 https://doi.org/10.3109/09537104.2014.971000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034210981
234 rdf:type schema:CreativeWork
235 https://www.grid.ac/institutes/grid.239276.b schema:alternateName Albert Einstein Medical Center
236 schema:name Department of Internal Medicine, Einstein Medical Center, Klein 303, 5501 Old York Road, 19141, Philadelphia, PA, USA
237 Department of Neurosciences, Einstein Medical Center, 5501 Old York Road, 19141, Philadelphia, PA, USA
238 rdf:type schema:Organization
239 https://www.grid.ac/institutes/grid.265008.9 schema:alternateName Thomas Jefferson University
240 schema:name Delaware Valley Nephrology Associates, Philadelphia, PA, USA
241 Department of Internal Medicine, Einstein Medical Center, Klein 303, 5501 Old York Road, 19141, Philadelphia, PA, USA
242 Sidney Kimmel College of Thomas Jefferson University, Philadelphia, PA, USA
243 rdf:type schema:Organization
244 https://www.grid.ac/institutes/grid.411115.1 schema:alternateName Hospital of the University of Pennsylvania
245 schema:name Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, 19104, Philadelphia, PA, USA
246 Division of Neurocritical Care, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
247 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...