The Cerebrovascular-Chronic Kidney Disease Connection: Perspectives and Mechanisms View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09-14

AUTHORS

Wei Ling Lau, Branko N. Huisa, Mark Fisher

ABSTRACT

Chronic kidney disease (CKD) is an independent risk factor for the development of cerebrovascular disease, particularly small vessel disease which can manifest in a variety of phenotypes ranging from lacunes to microbleeds. Small vessel disease likely contributes to cognitive dysfunction in the CKD population. Non-traditional risk factors for vascular injury in uremia include loss of calcification inhibitors, hyperphosphatemia, increased blood pressure variability, elastinolysis, platelet dysfunction, and chronic inflammation. In this review, we discuss the putative pathways by which these mechanisms may promote cerebrovascular disease and thus increase risk of future stroke in CKD patients. More... »

PAGES

67-76

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12975-016-0499-x

DOI

http://dx.doi.org/10.1007/s12975-016-0499-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039450654

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27628245


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