Early Brain Injury, an Evolving Frontier in Subarachnoid Hemorrhage Research View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-03-08

AUTHORS

Mutsumi Fujii, Junhao Yan, William B. Rolland, Yoshiteru Soejima, Basak Caner, John H. Zhang

ABSTRACT

Subarachnoid hemorrhage (SAH), predominantly caused by a ruptured aneurysm, is a devastating neurological disease that has a morbidity and mortality rate higher than 50 %. Most of the traditional in vivo research has focused on the pathophysiological or morphological changes of large arteries after intracisternal blood injection. This was due to a widely held assumption that delayed vasospasm following SAH was the major cause of delayed cerebral ischemia and poor outcome. However, the results of the CONSCIOUS-1 trial implicated some other pathophysiological factors, independent of angiographic vasospasm, in contributing to the poor clinical outcome. The term early brain injury (EBI) has been coined and describes the immediate injury to the brain after SAH, before onset of delayed vasospasm. During the EBI period, a ruptured aneurysm brings on many physiological derangements such as increasing intracranial pressure, decreased cerebral blood flow, and global cerebral ischemia. These events initiate secondary injuries such as blood–brain barrier disruption, inflammation, and oxidative cascades that all ultimately lead to cell death. Given the fact that the reversal of vasospasm does not appear to improve patient outcome, it could be argued that the treatment of EBI may successfully attenuate some of the devastating secondary injuries and improve the outcome of patients with SAH. In this review, we provide an overview of the major advances in EBI after SAH research. More... »

PAGES

432-446

References to SciGraph publications

  • 2012-05-15. Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits in BMC NEUROSCIENCE
  • 2010-11-17. Subarachnoid Hemorrhage Induces Gliosis and Increased Expression of the Pro-inflammatory Cytokine High Mobility Group Box 1 Protein in TRANSLATIONAL STROKE RESEARCH
  • 2012-04-22. Potential Contribution of Hypoxia-Inducible Factor-1α, Aquaporin-4, and Matrix Metalloproteinase-9 to Blood–Brain Barrier Disruption and Brain Edema After Experimental Subarachnoid Hemorrhage in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2009-10-13. Alpha Lipoic Acid Alleviates Oxidative Stress and Preserves Blood Brain Permeability in Rats with Subarachnoid Hemorrhage in NEUROCHEMICAL RESEARCH
  • 2011-05-16. Deferoxamine Reduces Early Brain Injury Following Subarachnoid Hemorrhage in TRENDS IN NEUROVASCULAR SURGERY
  • 2011-11-10. Elevated Peripheral Neutrophils and Matrix Metalloproteinase 9 as Biomarkers of Functional Outcome Following Subarachnoid Hemorrhage in TRANSLATIONAL STROKE RESEARCH
  • 2009-01-21. Atorvastatin ameliorates cerebral vasospasm and early brain injury after subarachnoid hemorrhage and inhibits caspase-dependent apoptosis pathway in BMC NEUROSCIENCE
  • 1986-09. Prevention of vasospasm in subarachnoid haemorrhage. A controlled study with nimodipine in ACTA NEUROCHIRURGICA
  • 2008. 3% Hypertonic saline following subarachnoid hemorrhage in rats in ACTA NEUROCHIRURGICA SUPPLEMENTS
  • 2011-01-08. Sampling of CSF via the Cisterna Magna and Blood Collection via the Heart Affects Brain Water Content in a Rat SAH Model in TRANSLATIONAL STROKE RESEARCH
  • 2011-05-24. Effects of Recombinant Osteopontin on Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in Rats in INTRACEREBRAL HEMORRHAGE RESEARCH
  • 2006. Neuroprotective effect of hyperbaric oxygen in a rat model of subarachnoid hemorrhage in BRAIN EDEMA XIII
  • 2005. Ischemia-induced endothelial cell dysfunction in INTRACRANIAL PRESSURE AND BRAIN MONITORING XII
  • 2011. Treatment with Ginsenoside Rb1, A Component of Panax Ginseng, Provides Neuroprotection in Rats Subjected to Subarachnoid Hemorrhage-Induced Brain Injury in EARLY BRAIN INJURY OR CEREBRAL VASOSPASM
  • 2007-09-17. Erythropoietin in patients with aneurysmal subarachnoid haemorrhage: a double blind randomised clinical trial in ACTA NEUROCHIRURGICA
  • 2012-03-22. Brain Water Content: a Misunderstood Measurement? in TRANSLATIONAL STROKE RESEARCH
  • 2011. Role of Osteopontin in Early Brain Injury After Subarachnoid Hemorrhage in Rats in EARLY BRAIN INJURY OR CEREBRAL VASOSPASM
  • 2011. Matrix Metalloproteinase 9 Inhibition Reduces Early Brain Injury in Cortex After Subarachnoid Hemorrhage in EARLY BRAIN INJURY OR CEREBRAL VASOSPASM
  • 2011. Tyrosine Phosphatase Inhibition Attenuates Early Brain Injury After Subarachnoid Hemorrhage in Rats in EARLY BRAIN INJURY OR CEREBRAL VASOSPASM
  • 2011. Protection of Minocycline on Early Brain Injury After Subarachnoid Hemorrhage in Rats in EARLY BRAIN INJURY OR CEREBRAL VASOSPASM
  • 2012-06-03. Inhibition of c-Jun N-terminal kinase prevents blood–brain barrier disruption and normalizes the expression of tight junction proteins clautin-5 and ZO-1 in a rat model of subarachnoid hemorrhage in ACTA NEUROCHIRURGICA
  • 2012-04-14. Heparin Reduces Neuroinflammation and Transsynaptic Neuronal Apoptosis in a Model of Subarachnoid Hemorrhage in TRANSLATIONAL STROKE RESEARCH
  • 2008. Effects of melatonin in early brain injury following subarachnoid hemorrhage in ACTA NEUROCHIRURGICA SUPPLEMENTS
  • 2011. Advances in Experimental Subarachnoid Hemorrhage in EARLY BRAIN INJURY OR CEREBRAL VASOSPASM
  • 2012-10-11. Role of autophagy in early brain injury after subarachnoid hemorrhage in rats in MOLECULAR BIOLOGY REPORTS
  • 2006-02. A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage in NEUROCRITICAL CARE
  • 2007-05. Cerebral vasospasm after subarachnoid hemorrhage: the emerging revolution in NATURE REVIEWS NEUROLOGY
  • 2011-02-26. Hyperbaric Oxygen for Cerebral Vasospasm and Brain Injury Following Subarachnoid Hemorrhage in TRANSLATIONAL STROKE RESEARCH
  • 2011. Apoptotic Mechanisms for Neuronal Cells in Early Brain Injury After Subarachnoid Hemorrhage in EARLY BRAIN INJURY OR CEREBRAL VASOSPASM
  • 2008-02-06. Intracisternal infusion of magnesium sulfate solution improved reduced cerebral blood flow induced by experimental subarachnoid hemorrhage in the rat in NEUROSURGICAL REVIEW
  • 2011-05-24. The Neuroprotective Effects of Cyclooxygenase-2 Inhibition in a Mouse Model of Aneurysmal Subarachnoid Hemorrhage in INTRACEREBRAL HEMORRHAGE RESEARCH
  • 2009-01-10. Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke in APOPTOSIS
  • 2010-12-15. Metamorphosis of Subarachnoid Hemorrhage Research: from Delayed Vasospasm to Early Brain Injury in MOLECULAR NEUROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12975-013-0257-2

    DOI

    http://dx.doi.org/10.1007/s12975-013-0257-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052230008

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23894255


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