Bench to Cribside: the Path for Developing a Neuroprotectant View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-12-21

AUTHORS

Nelina Ramanantsoa, Bobbi Fleiss, Myriam Bouslama, Boris Matrot, Leslie Schwendimann, Charles Cohen-Salmon, Pierre Gressens, Jorge Gallego

ABSTRACT

The consequences of perinatal brain injury include immeasurable anguish for families and substantial ongoing costs for care and support of effected children. Factors associated with perinatal brain injury in the preterm infant include inflammation and infection, and with increasing gestational age, a higher proportion is related to hypoxic–ischemic events, such as stroke and placental abruption. Over the past decade, we have acquired new insights in the mechanisms underpinning injury and many new tools to monitor outcome in perinatal brain injury in our experimental models. By embracing these new technologies, we can expedite the screening of novel therapies. This is critical as despite enormous efforts of the research community, hypothermia is the only viable neurotherapeutic, and this procedure is limited to term birth and postcardiac arrest hypoxic–ischemic events. Importantly, experimental and preliminary data in humans also indicate a considerable therapeutic potential for melatonin against perinatal brain injury. However, even if this suggested potential is proven, the complexity of the human condition means we are likely to need additional neuroprotective and regenerative strategies. Thus, within this review, we will outline what we consider the key stages of preclinical testing and development for a neuroprotectant or regenerative neurotherapy for perinatal brain injury. We will also highlight examples of novel small animal physiological and behavioral testing that gives small animal preclinical models greater clinical relevance. We hope these new tools and an integrated bench to cribside strategic plan will facilitate the fulfillment of our overarching goal, improving the long-term brain health and quality of life for infants suffering perinatal brain injury. More... »

PAGES

258-277

References to SciGraph publications

  • 2005-07. A review of the multiple actions of melatonin on the immune system in ENDOCRINE
  • 2012-06-05. High-field diffusion tensor imaging characterization of cerebral white matter injury in lipopolysaccharide-exposed fetal sheep in PEDIATRIC RESEARCH
  • 1995-05. Mild Hypothermia after Severe Transient Hypoxia-Ischemia Ameliorates Delayed Cerebral Energy Failure in the Newborn Piglet in PEDIATRIC RESEARCH
  • 2012-04-25. Mice do not require auditory input for the normal development of their ultrasonic vocalizations in BMC NEUROSCIENCE
  • 2001-09. Twenty-Four Hours of Mild Hypothermia in Unsedated Newborn Pigs Starting after a Severe Global Hypoxic-Ischemic Insult Is Not Neuroprotective in PEDIATRIC RESEARCH
  • 2011-10. Immediate Hypothermia Reduces Cardiac Troponin I After Hypoxic-Ischemic Encephalopathy in Newborn Pigs in PEDIATRIC RESEARCH
  • 2001-12. Effects of Melatonin Treatment in Septic Newborns in PEDIATRIC RESEARCH
  • 2003-05-07. Selective Cortical Alteration after Hypoxic-Ischemic Injury in the Very Immature Rat Brain in PEDIATRIC RESEARCH
  • 2010-10-08. Combination of intracortically administered VEGF and environmental enrichment enhances brain protection in developing rats in JOURNAL OF NEURAL TRANSMISSION
  • 2011-07-03. Functional ultrasound imaging of the brain in NATURE METHODS
  • 2007-02. Melatonin Reduces Inflammation and Cell Death in White Matter in the Mid-Gestation Fetal Sheep Following Umbilical Cord Occlusion in PEDIATRIC RESEARCH
  • 2007-05. Inhaled Nitric Oxide: Effects on Cerebral Growth and Injury in a Baboon Model of Premature Delivery in PEDIATRIC RESEARCH
  • 2003-02. White Matter Injury Following Systemic Endotoxemia or Asphyxia in the Fetal Sheep in NEUROCHEMICAL RESEARCH
  • 2009-08-20. Melatonin protects against oxidative damage in a neonatal rat model of bronchopulmonary dysplasia in WORLD JOURNAL OF PEDIATRICS
  • 2012-04-18. Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury in JOURNAL OF NEUROINFLAMMATION
  • 2011-11. Improved Neuroprotection with Melatonin-Augmented Hypothermia vs Hypothermia Alone in a Perinatal Asphyxia Model: a Randomized Study in PEDIATRIC RESEARCH
  • 2007-09-11. Advances in behavioral genetics: mouse models of autism in MOLECULAR PSYCHIATRY
  • 2006-08. Effect of Lipopolysaccharide on Global Gene Expression in the Immature Rat Brain in PEDIATRIC RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12975-012-0233-2

    DOI

    http://dx.doi.org/10.1007/s12975-012-0233-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014972536

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24323277


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Paediatrics and Reproductive Medicine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain Injuries", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Design", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hypoxia-Ischemia, Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infant", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infant, Newborn", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neuroprotective Agents", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.508487.6", 
              "name": [
                "Inserm U676, Hopital Robert Debre, 48 Blvd Serurier, 75019, Paris, France", 
                "Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ramanantsoa", 
            "givenName": "Nelina", 
            "id": "sg:person.01147157160.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147157160.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre for the Developing Brain, Perinatal Imaging and Health Department, Division of Imaging Sciences, King\u2019s College, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.13097.3c", 
              "name": [
                "Inserm U676, Hopital Robert Debre, 48 Blvd Serurier, 75019, Paris, France", 
                "Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine, Paris, France", 
                "Centre for the Developing Brain, Perinatal Imaging and Health Department, Division of Imaging Sciences, King\u2019s College, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fleiss", 
            "givenName": "Bobbi", 
            "id": "sg:person.0753527762.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753527762.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.508487.6", 
              "name": [
                "Inserm U676, Hopital Robert Debre, 48 Blvd Serurier, 75019, Paris, France", 
                "Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bouslama", 
            "givenName": "Myriam", 
            "id": "sg:person.01037254414.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037254414.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.508487.6", 
              "name": [
                "Inserm U676, Hopital Robert Debre, 48 Blvd Serurier, 75019, Paris, France", 
                "Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matrot", 
            "givenName": "Boris", 
            "id": "sg:person.01071700562.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071700562.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.508487.6", 
              "name": [
                "Inserm U676, Hopital Robert Debre, 48 Blvd Serurier, 75019, Paris, France", 
                "Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schwendimann", 
            "givenName": "Leslie", 
            "id": "sg:person.0671762705.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671762705.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.508487.6", 
              "name": [
                "Inserm U676, Hopital Robert Debre, 48 Blvd Serurier, 75019, Paris, France", 
                "Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cohen-Salmon", 
            "givenName": "Charles", 
            "id": "sg:person.0713574356.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713574356.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre for the Developing Brain, Perinatal Imaging and Health Department, Division of Imaging Sciences, King\u2019s College, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.13097.3c", 
              "name": [
                "Inserm U676, Hopital Robert Debre, 48 Blvd Serurier, 75019, Paris, France", 
                "Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine, Paris, France", 
                "Centre for the Developing Brain, Perinatal Imaging and Health Department, Division of Imaging Sciences, King\u2019s College, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gressens", 
            "givenName": "Pierre", 
            "id": "sg:person.0643134421.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643134421.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.508487.6", 
              "name": [
                "Inserm U676, Hopital Robert Debre, 48 Blvd Serurier, 75019, Paris, France", 
                "Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gallego", 
            "givenName": "Jorge", 
            "id": "sg:person.0706454533.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706454533.13"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00702-010-0496-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001700087", 
              "https://doi.org/10.1007/s00702-010-0496-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/pr.2012.72", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020319929", 
              "https://doi.org/10.1038/pr.2012.72"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12519-009-0041-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009274879", 
              "https://doi.org/10.1007/s12519-009-0041-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/pr.2011.292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019986708", 
              "https://doi.org/10.1038/pr.2011.292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/00006450-200109000-00017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034859677", 
              "https://doi.org/10.1203/00006450-200109000-00017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/01.pdr.0000072517.01207.87", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039340666", 
              "https://doi.org/10.1203/01.pdr.0000072517.01207.87"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2202-13-40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001319682", 
              "https://doi.org/10.1186/1471-2202-13-40"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-2094-9-70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043635156", 
              "https://doi.org/10.1186/1742-2094-9-70"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/00006450-200112000-00021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051547199", 
              "https://doi.org/10.1203/00006450-200112000-00021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1641", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019393142", 
              "https://doi.org/10.1038/nmeth.1641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/pdr.0b013e318045be20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018161007", 
              "https://doi.org/10.1203/pdr.0b013e318045be20"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4002082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041344858", 
              "https://doi.org/10.1038/sj.mp.4002082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/00006450-199505000-00019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023646417", 
              "https://doi.org/10.1203/00006450-199505000-00019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/endo:27:2:189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041873765", 
              "https://doi.org/10.1385/endo:27:2:189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/01.pdr.0000252546.20451.1a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012782264", 
              "https://doi.org/10.1203/01.pdr.0000252546.20451.1a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1022368915400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049147298", 
              "https://doi.org/10.1023/a:1022368915400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/01.pdr.0000228323.32445.7d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027340771", 
              "https://doi.org/10.1203/01.pdr.0000228323.32445.7d"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/pdr.0b013e31822941ee", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041297739", 
              "https://doi.org/10.1203/pdr.0b013e31822941ee"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-12-21", 
        "datePublishedReg": "2012-12-21", 
        "description": "The consequences of perinatal brain injury include immeasurable anguish for families and substantial ongoing costs for care and support of effected children. Factors associated with perinatal brain injury in the preterm infant include inflammation and infection, and with increasing gestational age, a higher proportion is related to hypoxic\u2013ischemic events, such as stroke and placental abruption. Over the past decade, we have acquired new insights in the mechanisms underpinning injury and many new tools to monitor outcome in perinatal brain injury in our experimental models. By embracing these new technologies, we can expedite the screening of novel therapies. This is critical as despite enormous efforts of the research community, hypothermia is the only viable neurotherapeutic, and this procedure is limited to term birth and postcardiac arrest hypoxic\u2013ischemic events. Importantly, experimental and preliminary data in humans also indicate a considerable therapeutic potential for melatonin against perinatal brain injury. However, even if this suggested potential is proven, the complexity of the human condition means we are likely to need additional neuroprotective and regenerative strategies. Thus, within this review, we will outline what we consider the key stages of preclinical testing and development for a neuroprotectant or regenerative neurotherapy for perinatal brain injury. We will also highlight examples of novel small animal physiological and behavioral testing that gives small animal preclinical models greater clinical relevance. We hope these new tools and an integrated bench to cribside strategic plan will facilitate the fulfillment of our overarching goal, improving the long-term brain health and quality of life for infants suffering perinatal brain injury.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s12975-012-0233-2", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1042288", 
            "issn": [
              "1868-4483", 
              "1868-601X"
            ], 
            "name": "Translational Stroke Research", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "4"
          }
        ], 
        "keywords": [
          "perinatal brain injury", 
          "hypoxic-ischemic events", 
          "brain injury", 
          "long-term brain health", 
          "quality of life", 
          "great clinical relevance", 
          "considerable therapeutic potential", 
          "preterm infants", 
          "placental abruption", 
          "term births", 
          "gestational age", 
          "brain health", 
          "novel therapies", 
          "behavioral testing", 
          "clinical relevance", 
          "injury", 
          "preclinical testing", 
          "therapeutic potential", 
          "experimental model", 
          "preliminary data", 
          "infants", 
          "regenerative strategies", 
          "higher proportion", 
          "abruption", 
          "neuroprotectant", 
          "inflammation", 
          "hypothermia", 
          "therapy", 
          "small animals", 
          "cribside", 
          "stroke", 
          "infection", 
          "neurotherapeutics", 
          "melatonin", 
          "care", 
          "birth", 
          "age", 
          "outcomes", 
          "neurotherapy", 
          "children", 
          "testing", 
          "ongoing costs", 
          "new tool", 
          "health", 
          "screening", 
          "animals", 
          "events", 
          "human condition", 
          "past decade", 
          "review", 
          "humans", 
          "new insights", 
          "proportion", 
          "enormous efforts", 
          "overarching goal", 
          "factors", 
          "life", 
          "potential", 
          "relevance", 
          "procedure", 
          "strategic plan", 
          "mechanism", 
          "stage", 
          "family", 
          "tool", 
          "data", 
          "support", 
          "development", 
          "consequences", 
          "quality", 
          "strategies", 
          "plan", 
          "key stages", 
          "bench", 
          "anguish", 
          "decades", 
          "goal", 
          "efforts", 
          "new technologies", 
          "insights", 
          "conditions", 
          "community", 
          "model", 
          "cost", 
          "fulfillment", 
          "research community", 
          "complexity", 
          "technology", 
          "example", 
          "path", 
          "immeasurable anguish", 
          "substantial ongoing costs", 
          "effected children", 
          "only viable neurotherapeutic", 
          "viable neurotherapeutic", 
          "postcardiac arrest hypoxic\u2013ischemic events", 
          "arrest hypoxic\u2013ischemic events", 
          "regenerative neurotherapy", 
          "novel small animal", 
          "small animal preclinical models greater clinical relevance", 
          "animal preclinical models greater clinical relevance", 
          "preclinical models greater clinical relevance", 
          "models greater clinical relevance"
        ], 
        "name": "Bench to Cribside: the Path for Developing a Neuroprotectant", 
        "pagination": "258-277", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1014972536"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12975-012-0233-2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24323277"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12975-012-0233-2", 
          "https://app.dimensions.ai/details/publication/pub.1014972536"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-11-01T18:18", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_583.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s12975-012-0233-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12975-012-0233-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12975-012-0233-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12975-012-0233-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12975-012-0233-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    328 TRIPLES      22 PREDICATES      156 URIs      129 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12975-012-0233-2 schema:about N0fd6ef1230b94662a00d03b2c4aeaaf6
    2 N30b027d5522f49e1b1657ce8b54d6335
    3 N352beba43ca3430ba80eda73d480ea63
    4 N38a250ac0b3149d389c645886e3a6065
    5 N468ef63406324e8d8c00e81e64eec505
    6 N6bcaa73e7a27406aadbf5b869f202396
    7 N704043d378ee4f62ade121b08a5c0c64
    8 Ndbb6349fbdc54582bc906b87e225ccb0
    9 anzsrc-for:11
    10 anzsrc-for:1109
    11 anzsrc-for:1114
    12 schema:author N3ed9e26e9e204c999c79980227ffc424
    13 schema:citation sg:pub.10.1007/s00702-010-0496-2
    14 sg:pub.10.1007/s12519-009-0041-2
    15 sg:pub.10.1023/a:1022368915400
    16 sg:pub.10.1038/nmeth.1641
    17 sg:pub.10.1038/pr.2011.292
    18 sg:pub.10.1038/pr.2012.72
    19 sg:pub.10.1038/sj.mp.4002082
    20 sg:pub.10.1186/1471-2202-13-40
    21 sg:pub.10.1186/1742-2094-9-70
    22 sg:pub.10.1203/00006450-199505000-00019
    23 sg:pub.10.1203/00006450-200109000-00017
    24 sg:pub.10.1203/00006450-200112000-00021
    25 sg:pub.10.1203/01.pdr.0000072517.01207.87
    26 sg:pub.10.1203/01.pdr.0000228323.32445.7d
    27 sg:pub.10.1203/01.pdr.0000252546.20451.1a
    28 sg:pub.10.1203/pdr.0b013e318045be20
    29 sg:pub.10.1203/pdr.0b013e31822941ee
    30 sg:pub.10.1385/endo:27:2:189
    31 schema:datePublished 2012-12-21
    32 schema:datePublishedReg 2012-12-21
    33 schema:description The consequences of perinatal brain injury include immeasurable anguish for families and substantial ongoing costs for care and support of effected children. Factors associated with perinatal brain injury in the preterm infant include inflammation and infection, and with increasing gestational age, a higher proportion is related to hypoxic–ischemic events, such as stroke and placental abruption. Over the past decade, we have acquired new insights in the mechanisms underpinning injury and many new tools to monitor outcome in perinatal brain injury in our experimental models. By embracing these new technologies, we can expedite the screening of novel therapies. This is critical as despite enormous efforts of the research community, hypothermia is the only viable neurotherapeutic, and this procedure is limited to term birth and postcardiac arrest hypoxic–ischemic events. Importantly, experimental and preliminary data in humans also indicate a considerable therapeutic potential for melatonin against perinatal brain injury. However, even if this suggested potential is proven, the complexity of the human condition means we are likely to need additional neuroprotective and regenerative strategies. Thus, within this review, we will outline what we consider the key stages of preclinical testing and development for a neuroprotectant or regenerative neurotherapy for perinatal brain injury. We will also highlight examples of novel small animal physiological and behavioral testing that gives small animal preclinical models greater clinical relevance. We hope these new tools and an integrated bench to cribside strategic plan will facilitate the fulfillment of our overarching goal, improving the long-term brain health and quality of life for infants suffering perinatal brain injury.
    34 schema:genre article
    35 schema:inLanguage en
    36 schema:isAccessibleForFree false
    37 schema:isPartOf Na61ac03c7686412c8021ae40e413041f
    38 Nfca0cfe116aa42a2b4640dbc46102c9a
    39 sg:journal.1042288
    40 schema:keywords abruption
    41 age
    42 anguish
    43 animal preclinical models greater clinical relevance
    44 animals
    45 arrest hypoxic–ischemic events
    46 behavioral testing
    47 bench
    48 birth
    49 brain health
    50 brain injury
    51 care
    52 children
    53 clinical relevance
    54 community
    55 complexity
    56 conditions
    57 consequences
    58 considerable therapeutic potential
    59 cost
    60 cribside
    61 data
    62 decades
    63 development
    64 effected children
    65 efforts
    66 enormous efforts
    67 events
    68 example
    69 experimental model
    70 factors
    71 family
    72 fulfillment
    73 gestational age
    74 goal
    75 great clinical relevance
    76 health
    77 higher proportion
    78 human condition
    79 humans
    80 hypothermia
    81 hypoxic-ischemic events
    82 immeasurable anguish
    83 infants
    84 infection
    85 inflammation
    86 injury
    87 insights
    88 key stages
    89 life
    90 long-term brain health
    91 mechanism
    92 melatonin
    93 model
    94 models greater clinical relevance
    95 neuroprotectant
    96 neurotherapeutics
    97 neurotherapy
    98 new insights
    99 new technologies
    100 new tool
    101 novel small animal
    102 novel therapies
    103 ongoing costs
    104 only viable neurotherapeutic
    105 outcomes
    106 overarching goal
    107 past decade
    108 path
    109 perinatal brain injury
    110 placental abruption
    111 plan
    112 postcardiac arrest hypoxic–ischemic events
    113 potential
    114 preclinical models greater clinical relevance
    115 preclinical testing
    116 preliminary data
    117 preterm infants
    118 procedure
    119 proportion
    120 quality
    121 quality of life
    122 regenerative neurotherapy
    123 regenerative strategies
    124 relevance
    125 research community
    126 review
    127 screening
    128 small animal preclinical models greater clinical relevance
    129 small animals
    130 stage
    131 strategic plan
    132 strategies
    133 stroke
    134 substantial ongoing costs
    135 support
    136 technology
    137 term births
    138 testing
    139 therapeutic potential
    140 therapy
    141 tool
    142 viable neurotherapeutic
    143 schema:name Bench to Cribside: the Path for Developing a Neuroprotectant
    144 schema:pagination 258-277
    145 schema:productId N5500fb5d784346698632b99869ec1ad3
    146 N8394a920fb9e481bbf086d757108f374
    147 Ndb7e7b846e924859b97061ef32387b88
    148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014972536
    149 https://doi.org/10.1007/s12975-012-0233-2
    150 schema:sdDatePublished 2021-11-01T18:18
    151 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    152 schema:sdPublisher N45f4eb80b3b144828405e0c707eb3248
    153 schema:url https://doi.org/10.1007/s12975-012-0233-2
    154 sgo:license sg:explorer/license/
    155 sgo:sdDataset articles
    156 rdf:type schema:ScholarlyArticle
    157 N0fd6ef1230b94662a00d03b2c4aeaaf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Infant
    159 rdf:type schema:DefinedTerm
    160 N13bd98c7fe9849349b301cce2c9472a4 rdf:first sg:person.0671762705.62
    161 rdf:rest Nf2b6b7bc792043b8a3458fd024b7793d
    162 N2c1d05f3917b4e0eb31a8ee15511d131 rdf:first sg:person.01071700562.45
    163 rdf:rest N13bd98c7fe9849349b301cce2c9472a4
    164 N2f27a59d1ebf46b8991e510fe22d9c50 rdf:first sg:person.0706454533.13
    165 rdf:rest rdf:nil
    166 N30b027d5522f49e1b1657ce8b54d6335 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Neuroprotective Agents
    168 rdf:type schema:DefinedTerm
    169 N352beba43ca3430ba80eda73d480ea63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Humans
    171 rdf:type schema:DefinedTerm
    172 N38a250ac0b3149d389c645886e3a6065 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Hypoxia-Ischemia, Brain
    174 rdf:type schema:DefinedTerm
    175 N3ed9e26e9e204c999c79980227ffc424 rdf:first sg:person.01147157160.53
    176 rdf:rest Ndd6758a1e9b34527a8a4614b258c4292
    177 N45f4eb80b3b144828405e0c707eb3248 schema:name Springer Nature - SN SciGraph project
    178 rdf:type schema:Organization
    179 N468ef63406324e8d8c00e81e64eec505 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Animals
    181 rdf:type schema:DefinedTerm
    182 N5500fb5d784346698632b99869ec1ad3 schema:name doi
    183 schema:value 10.1007/s12975-012-0233-2
    184 rdf:type schema:PropertyValue
    185 N6bcaa73e7a27406aadbf5b869f202396 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Brain Injuries
    187 rdf:type schema:DefinedTerm
    188 N704043d378ee4f62ade121b08a5c0c64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Infant, Newborn
    190 rdf:type schema:DefinedTerm
    191 N782ca8271cfc4f26a88043214dca2d93 rdf:first sg:person.0643134421.39
    192 rdf:rest N2f27a59d1ebf46b8991e510fe22d9c50
    193 N8394a920fb9e481bbf086d757108f374 schema:name dimensions_id
    194 schema:value pub.1014972536
    195 rdf:type schema:PropertyValue
    196 Na61ac03c7686412c8021ae40e413041f schema:volumeNumber 4
    197 rdf:type schema:PublicationVolume
    198 Ndb4ec2c140d54886b8f2e9f309292f45 rdf:first sg:person.01037254414.09
    199 rdf:rest N2c1d05f3917b4e0eb31a8ee15511d131
    200 Ndb7e7b846e924859b97061ef32387b88 schema:name pubmed_id
    201 schema:value 24323277
    202 rdf:type schema:PropertyValue
    203 Ndbb6349fbdc54582bc906b87e225ccb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Drug Design
    205 rdf:type schema:DefinedTerm
    206 Ndd6758a1e9b34527a8a4614b258c4292 rdf:first sg:person.0753527762.82
    207 rdf:rest Ndb4ec2c140d54886b8f2e9f309292f45
    208 Nf2b6b7bc792043b8a3458fd024b7793d rdf:first sg:person.0713574356.80
    209 rdf:rest N782ca8271cfc4f26a88043214dca2d93
    210 Nfca0cfe116aa42a2b4640dbc46102c9a schema:issueNumber 2
    211 rdf:type schema:PublicationIssue
    212 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    213 schema:name Medical and Health Sciences
    214 rdf:type schema:DefinedTerm
    215 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    216 schema:name Neurosciences
    217 rdf:type schema:DefinedTerm
    218 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
    219 schema:name Paediatrics and Reproductive Medicine
    220 rdf:type schema:DefinedTerm
    221 sg:journal.1042288 schema:issn 1868-4483
    222 1868-601X
    223 schema:name Translational Stroke Research
    224 schema:publisher Springer Nature
    225 rdf:type schema:Periodical
    226 sg:person.01037254414.09 schema:affiliation grid-institutes:grid.508487.6
    227 schema:familyName Bouslama
    228 schema:givenName Myriam
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037254414.09
    230 rdf:type schema:Person
    231 sg:person.01071700562.45 schema:affiliation grid-institutes:grid.508487.6
    232 schema:familyName Matrot
    233 schema:givenName Boris
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071700562.45
    235 rdf:type schema:Person
    236 sg:person.01147157160.53 schema:affiliation grid-institutes:grid.508487.6
    237 schema:familyName Ramanantsoa
    238 schema:givenName Nelina
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147157160.53
    240 rdf:type schema:Person
    241 sg:person.0643134421.39 schema:affiliation grid-institutes:grid.13097.3c
    242 schema:familyName Gressens
    243 schema:givenName Pierre
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643134421.39
    245 rdf:type schema:Person
    246 sg:person.0671762705.62 schema:affiliation grid-institutes:grid.508487.6
    247 schema:familyName Schwendimann
    248 schema:givenName Leslie
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671762705.62
    250 rdf:type schema:Person
    251 sg:person.0706454533.13 schema:affiliation grid-institutes:grid.508487.6
    252 schema:familyName Gallego
    253 schema:givenName Jorge
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706454533.13
    255 rdf:type schema:Person
    256 sg:person.0713574356.80 schema:affiliation grid-institutes:grid.508487.6
    257 schema:familyName Cohen-Salmon
    258 schema:givenName Charles
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713574356.80
    260 rdf:type schema:Person
    261 sg:person.0753527762.82 schema:affiliation grid-institutes:grid.13097.3c
    262 schema:familyName Fleiss
    263 schema:givenName Bobbi
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753527762.82
    265 rdf:type schema:Person
    266 sg:pub.10.1007/s00702-010-0496-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001700087
    267 https://doi.org/10.1007/s00702-010-0496-2
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1007/s12519-009-0041-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009274879
    270 https://doi.org/10.1007/s12519-009-0041-2
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1023/a:1022368915400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049147298
    273 https://doi.org/10.1023/a:1022368915400
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nmeth.1641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019393142
    276 https://doi.org/10.1038/nmeth.1641
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/pr.2011.292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019986708
    279 https://doi.org/10.1038/pr.2011.292
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/pr.2012.72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020319929
    282 https://doi.org/10.1038/pr.2012.72
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/sj.mp.4002082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041344858
    285 https://doi.org/10.1038/sj.mp.4002082
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1186/1471-2202-13-40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001319682
    288 https://doi.org/10.1186/1471-2202-13-40
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1186/1742-2094-9-70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043635156
    291 https://doi.org/10.1186/1742-2094-9-70
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1203/00006450-199505000-00019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023646417
    294 https://doi.org/10.1203/00006450-199505000-00019
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1203/00006450-200109000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034859677
    297 https://doi.org/10.1203/00006450-200109000-00017
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1203/00006450-200112000-00021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051547199
    300 https://doi.org/10.1203/00006450-200112000-00021
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1203/01.pdr.0000072517.01207.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039340666
    303 https://doi.org/10.1203/01.pdr.0000072517.01207.87
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1203/01.pdr.0000228323.32445.7d schema:sameAs https://app.dimensions.ai/details/publication/pub.1027340771
    306 https://doi.org/10.1203/01.pdr.0000228323.32445.7d
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1203/01.pdr.0000252546.20451.1a schema:sameAs https://app.dimensions.ai/details/publication/pub.1012782264
    309 https://doi.org/10.1203/01.pdr.0000252546.20451.1a
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1203/pdr.0b013e318045be20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018161007
    312 https://doi.org/10.1203/pdr.0b013e318045be20
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1203/pdr.0b013e31822941ee schema:sameAs https://app.dimensions.ai/details/publication/pub.1041297739
    315 https://doi.org/10.1203/pdr.0b013e31822941ee
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1385/endo:27:2:189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041873765
    318 https://doi.org/10.1385/endo:27:2:189
    319 rdf:type schema:CreativeWork
    320 grid-institutes:grid.13097.3c schema:alternateName Centre for the Developing Brain, Perinatal Imaging and Health Department, Division of Imaging Sciences, King’s College, London, UK
    321 schema:name Centre for the Developing Brain, Perinatal Imaging and Health Department, Division of Imaging Sciences, King’s College, London, UK
    322 Inserm U676, Hopital Robert Debre, 48 Blvd Serurier, 75019, Paris, France
    323 Université Paris Diderot, Faculté de Médecine, Paris, France
    324 rdf:type schema:Organization
    325 grid-institutes:grid.508487.6 schema:alternateName Université Paris Diderot, Faculté de Médecine, Paris, France
    326 schema:name Inserm U676, Hopital Robert Debre, 48 Blvd Serurier, 75019, Paris, France
    327 Université Paris Diderot, Faculté de Médecine, Paris, France
    328 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...