A serial optical frequency-domain imaging study of early and late vascular responses to bioresorbable-polymer sirolimus-eluting stents for the treatment of ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-04-25

AUTHORS

Tomonori Itoh, Hiromasa Otake, Takumi Kimura, Yoshiro Tsukiyama, Tatsuo Kikuchi, Munenori Okubo, Takatoshi Hayashi, Takayuki Okamura, Shoichi Kuramitsu, Takashi Morita, Shinjo Sonoda, Shozo Ishihara, Nehiro Kuriyama, Takaaki Isshiki, Tsunenari Soeda, Kiyoshi Hibi, Toshiro Shinke, Yoshihiro Morino

ABSTRACT

The purpose of this study was to assess early and late vascular healing in response to bioresorbable-polymer sirolimus-eluting stents (BP-SESs) for the treatment of patients with ST-elevation myocardial infarction (STEMI) and stable coronary artery disease (CAD). A total of 106 patients with STEMI and 101 patients with stable-CAD were enrolled. Optical frequency-domain images were acquired at baseline, at 1- or 3-month follow-up, and at 12-month follow-up. In the STEMI and CAD cohorts, the percentage of uncovered struts (%US) was significantly and remarkably decreased during early two points and at 12-month (the STEMI cohort: 1-month: 18.75 ± 0.78%, 3-month: 10.19 ± 0.77%, 12-month: 1.80 ± 0.72%; p < 0.001, the CAD cohort: 1-month: 9.44 ± 0.78%, 3-month: 7.78 ± 0.78%, 12-month: 1.07 ± 0.73%; p < 0.001 respectively). The average peri-strut low-intensity area (PLIA) score in the STEMI cohort was significantly decreased during follow-up period (1.90 ± 1.14, 1.18 ± 1.25, and 1.01 ± 0.72; p ≤ 0.001), whereas the one in the CAD cohort was not significantly changed (0.89 ± 1.24, 0.67 ± 1.07, and 0.64 ± 0.72; p = 0.59). In comparison with both groups, differences of %US and PLIA score at early two points were almost disappeared or close at 12 months. The strut-coverage and healing processes in the early phase after BP-SES implantation were significantly improved in both cohorts, especially markedly in STEMI patients. At 1 year, qualitatively and quantitatively consistent neointimal coverage was achieved in both pathogenetic groups. More... »

PAGES

281-292

Journal

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12928-021-00777-4

DOI

http://dx.doi.org/10.1007/s12928-021-00777-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1137477043

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33895962


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18 schema:description The purpose of this study was to assess early and late vascular healing in response to bioresorbable-polymer sirolimus-eluting stents (BP-SESs) for the treatment of patients with ST-elevation myocardial infarction (STEMI) and stable coronary artery disease (CAD). A total of 106 patients with STEMI and 101 patients with stable-CAD were enrolled. Optical frequency-domain images were acquired at baseline, at 1- or 3-month follow-up, and at 12-month follow-up. In the STEMI and CAD cohorts, the percentage of uncovered struts (%US) was significantly and remarkably decreased during early two points and at 12-month (the STEMI cohort: 1-month: 18.75 ± 0.78%, 3-month: 10.19 ± 0.77%, 12-month: 1.80 ± 0.72%; p < 0.001, the CAD cohort: 1-month: 9.44 ± 0.78%, 3-month: 7.78 ± 0.78%, 12-month: 1.07 ± 0.73%; p < 0.001 respectively). The average peri-strut low-intensity area (PLIA) score in the STEMI cohort was significantly decreased during follow-up period (1.90 ± 1.14, 1.18 ± 1.25, and 1.01 ± 0.72; p ≤ 0.001), whereas the one in the CAD cohort was not significantly changed (0.89 ± 1.24, 0.67 ± 1.07, and 0.64 ± 0.72; p = 0.59). In comparison with both groups, differences of %US and PLIA score at early two points were almost disappeared or close at 12 months. The strut-coverage and healing processes in the early phase after BP-SES implantation were significantly improved in both cohorts, especially markedly in STEMI patients. At 1 year, qualitatively and quantitatively consistent neointimal coverage was achieved in both pathogenetic groups.
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24 schema:keywords BP-SES implantation
25 CAD cohort
26 ST-elevation myocardial infarction
27 STEMI cohort
28 STEMI patients
29 acute myocardial infarction
30 area score
31 artery disease
32 baseline
33 bioresorbable polymer sirolimus-eluting stent
34 cohort
35 comparison
36 coronary artery disease
37 coronary artery disease patients
38 coverage
39 differences
40 disease
41 disease patients
42 early phase
43 frequency domain image
44 group
45 healing
46 healing process
47 images
48 imaging studies
49 implantation
50 infarction
51 late vascular response
52 months
53 myocardial infarction
54 neointimal coverage
55 pathogenetic groups
56 patients
57 percentage
58 period
59 phase
60 point
61 process
62 purpose
63 response
64 results
65 scores
66 sirolimus-eluting stents
67 stable coronary artery disease
68 stable coronary artery disease patients
69 stents
70 struts
71 study
72 total
73 treatment
74 treatment of patients
75 uncovered struts
76 uses
77 vascular healing
78 vascular responses
79 years
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