Clinical outcomes of patients treated using very short duration dual antiplatelet therapy after implantation of biodegradable-polymer drug-eluting stents: rationale and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-08-10

AUTHORS

Masaru Ishida, Fumiaki Takahashi, Iwao Goto, Masanobu Niiyama, Hidenori Saitoh, Tsubasa Sakamoto, Yuko Maegawa, Takuya Osaki, Osamu Nishiyama, Hiroshi Endo, Ryohei Sakamoto, Tsuyoshi Kojima, Yorihiko Koeda, Takumi Kimura, Tomonori Itoh, Yoshihiro Morino

ABSTRACT

Several studies have demonstrated the safety and feasibility of short (3–6 months) and very short duration (< 2 months) dual antiplatelet therapy (DAPT) in patients with a durable-polymer drug-eluting stent (DP-DES). However, the clinical importance of using very short duration DAPT has yet to be established in patients with a biodegradable polymer drug-eluting stent (BP-DES). The aim of this REIWA registry (multicenter and prospective registry; investigation of clinical outcomes of patients treated with short duration dual antiplatelet therapy after implantation of biodresorbable-polymer drug-eluting stent: a multicenter, prospective registry from Iwate medical university affiliated hospitals) is to determine the safety and feasibility of using 1-month DAPT followed by P2Y12 inhibitor monotherapy in patients after BP-DES implantation. This study is an observational, prospective, multicenter registry encompassing the entire local medical region of Iwate Prefecture (northern area of mainland Japan). A total of 1200 patients who underwent successful PCI with a novel thin strut BP-DES (Synergy, Ultimaster or Orsiro) and are considered to be appropriate patients for very short DAPT, are registered and subsequently administered 1-month DAPT followed by P2Y12 inhibitor monotherapy (clopidogrel 75 mg/day or prasugrel 3.75 mg/day). The primary endpoint was a composite of cardiovascular and bleeding events, which included cardiovascular death, spontaneous myocardial infarction, definite stent thrombosis, ischemic or hemorrhagic stroke, or TIMI major or minor bleeding at 12 months. The REIWA registry (UMIN000037321) will demonstrate both the safety and feasibility of using 1-month DAPT in patients with BP-DES. Furthermore, results of this study will also be able to provide supportive evidence for P2Y12 inhibitor monotherapy after 1-month DAPT following BP-DES implantation. More... »

PAGES

398-404

Journal

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12928-020-00694-y

DOI

http://dx.doi.org/10.1007/s12928-020-00694-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1130007137

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32776221


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27 schema:description Several studies have demonstrated the safety and feasibility of short (3–6 months) and very short duration (< 2 months) dual antiplatelet therapy (DAPT) in patients with a durable-polymer drug-eluting stent (DP-DES). However, the clinical importance of using very short duration DAPT has yet to be established in patients with a biodegradable polymer drug-eluting stent (BP-DES). The aim of this REIWA registry (multicenter and prospective registry; investigation of clinical outcomes of patients treated with short duration dual antiplatelet therapy after implantation of biodresorbable-polymer drug-eluting stent: a multicenter, prospective registry from Iwate medical university affiliated hospitals) is to determine the safety and feasibility of using 1-month DAPT followed by P2Y12 inhibitor monotherapy in patients after BP-DES implantation. This study is an observational, prospective, multicenter registry encompassing the entire local medical region of Iwate Prefecture (northern area of mainland Japan). A total of 1200 patients who underwent successful PCI with a novel thin strut BP-DES (Synergy, Ultimaster or Orsiro) and are considered to be appropriate patients for very short DAPT, are registered and subsequently administered 1-month DAPT followed by P2Y12 inhibitor monotherapy (clopidogrel 75 mg/day or prasugrel 3.75 mg/day). The primary endpoint was a composite of cardiovascular and bleeding events, which included cardiovascular death, spontaneous myocardial infarction, definite stent thrombosis, ischemic or hemorrhagic stroke, or TIMI major or minor bleeding at 12 months. The REIWA registry (UMIN000037321) will demonstrate both the safety and feasibility of using 1-month DAPT in patients with BP-DES. Furthermore, results of this study will also be able to provide supportive evidence for P2Y12 inhibitor monotherapy after 1-month DAPT following BP-DES implantation.
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35 Iwate Prefecture
36 P2Y12 inhibitor monotherapy
37 PCI
38 Prefecture
39 TIMI
40 aim
41 antiplatelet therapy
42 appropriate patients
43 biodegradable polymer drug-eluting stents
44 bleeding
45 cardiovascular death
46 clinical importance
47 clinical outcomes
48 composites
49 death
50 definite stent thrombosis
51 design
52 drug-eluting stents
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55 endpoint
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61 importance
62 infarction
63 inhibitor monotherapy
64 medical region
65 minor bleeding
66 monotherapy
67 months
68 multicenter registry
69 myocardial infarction
70 outcomes
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